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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42597

FusionGeneSummary for ZC3H7A_SKIL

check button Fusion gene summary
Fusion gene informationFusion gene name: ZC3H7A_SKIL
Fusion gene ID: 42597
HgeneTgene
Gene symbol

ZC3H7A

SKIL

Gene ID

29066

6498

Gene namezinc finger CCCH-type containing 7ASKI like proto-oncogene
SynonymsHSPC055|ZC3H7|ZC3HDC7SNO|SnoA|SnoI|SnoN
Cytomap

16p13.13

3q26.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH domain-containing protein 7Azinc finger CCCH-type domain containing 7zinc-finger protein AY163807ski-like proteinSKI-like oncogeneski-related oncogene snoN
Modification date2018051920180523
UniProtAcc

Q8IWR0

P12757

Ensembl transtripts involved in fusion geneENST00000396516, ENST00000355758, 
ENST00000575984, ENST00000575170, 
ENST00000259119, ENST00000426052, 
ENST00000490989, ENST00000413427, 
ENST00000458537, 
Fusion gene scores* DoF score5 X 5 X 5=1256 X 3 X 3=54
# samples 66
** MAII scorelog2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/54*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZC3H7A [Title/Abstract] AND SKIL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-EW-A1J1-01AZC3H7Achr16

11890980

-SKILchr3

170077487

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000396516ENST00000259119ZC3H7Achr16

11890980

-SKILchr3

170077487

+
intron-5UTRENST00000396516ENST00000426052ZC3H7Achr16

11890980

-SKILchr3

170077487

+
intron-3UTRENST00000396516ENST00000490989ZC3H7Achr16

11890980

-SKILchr3

170077487

+
intron-5UTRENST00000396516ENST00000413427ZC3H7Achr16

11890980

-SKILchr3

170077487

+
intron-5UTRENST00000396516ENST00000458537ZC3H7Achr16

11890980

-SKILchr3

170077487

+
5UTR-5UTRENST00000355758ENST00000259119ZC3H7Achr16

11890980

-SKILchr3

170077487

+
5UTR-5UTRENST00000355758ENST00000426052ZC3H7Achr16

11890980

-SKILchr3

170077487

+
5UTR-3UTRENST00000355758ENST00000490989ZC3H7Achr16

11890980

-SKILchr3

170077487

+
5UTR-5UTRENST00000355758ENST00000413427ZC3H7Achr16

11890980

-SKILchr3

170077487

+
5UTR-5UTRENST00000355758ENST00000458537ZC3H7Achr16

11890980

-SKILchr3

170077487

+
intron-5UTRENST00000575984ENST00000259119ZC3H7Achr16

11890980

-SKILchr3

170077487

+
intron-5UTRENST00000575984ENST00000426052ZC3H7Achr16

11890980

-SKILchr3

170077487

+
intron-3UTRENST00000575984ENST00000490989ZC3H7Achr16

11890980

-SKILchr3

170077487

+
intron-5UTRENST00000575984ENST00000413427ZC3H7Achr16

11890980

-SKILchr3

170077487

+
intron-5UTRENST00000575984ENST00000458537ZC3H7Achr16

11890980

-SKILchr3

170077487

+
5UTR-5UTRENST00000575170ENST00000259119ZC3H7Achr16

11890980

-SKILchr3

170077487

+
5UTR-5UTRENST00000575170ENST00000426052ZC3H7Achr16

11890980

-SKILchr3

170077487

+
5UTR-3UTRENST00000575170ENST00000490989ZC3H7Achr16

11890980

-SKILchr3

170077487

+
5UTR-5UTRENST00000575170ENST00000413427ZC3H7Achr16

11890980

-SKILchr3

170077487

+
5UTR-5UTRENST00000575170ENST00000458537ZC3H7Achr16

11890980

-SKILchr3

170077487

+

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FusionProtFeatures for ZC3H7A_SKIL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZC3H7A

Q8IWR0

SKIL

P12757

May be a specific regulator of miRNA biogenesis. Bindsto microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the3'-ATA(A/T)-5' motif in the apical loop.{ECO:0000269|PubMed:28431233}. May have regulatory role in cell division ordifferentiation in response to extracellular signals.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZC3H7A_SKIL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZC3H7A_SKIL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZC3H7APAK1, STK3, BMI1, BIRC7, NTRK1, XPO1, G3BP1SKILSMAD3, SMAD2, FZR1, SMAD4, SMURF2, SKIL, SKI, SNW1, RNF111, NEDD4, WWP1, ING2, NCOR1, NCOR2, SIN3A, HDAC1, RB1, TGFBR1, SMAD1, ESR1, RB1CC1, AXIN1, MAP3K7, ZZEF1, PPL, PIAS1, SRP72, SASH1, TDP2, TPM2, COL4A2, SNRNP70, PTPRF, XRCC6, NID1, GLUL, FBLN1, EEF1G, PSMC2, TFPI2, UBE2I, RNF4, EIF4G2, LRP1, CHD3, PAPPA, TDG, NID2, KRT81, GOLGB1, SNX17, SETDB1, ZBTB6, PSG3, CAMSAP1, CBX4, DHX30, CXXC5, THAP5, HIPK1, CHPF, PIAS4, ASCC3, PLCD3, SPARCL1, SVEP1, MORC4, TSKU, PYCR2, UIMC1, TRIM62, ZNF106, ZBTB3, HEYL, IL36RN, ZMYM2, USP25, FAF1, TTF2, MACF1, TRAK1, THSD7A, HEY1, PIAS3, RPS27, ZNF200, MVP, TRIM33, AES, DRG1, STK16, OIP5, VPS28, NXF3, PML


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZC3H7A_SKIL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZC3H7A_SKIL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSKILC0034069Pulmonary Fibrosis1CTD_human
TgeneSKILC0037274Dermatologic disorders1CTD_human
TgeneSKILC0311375Arsenic Poisoning1CTD_human
TgeneSKILC2931434Paraquat lung1CTD_human