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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42566

FusionGeneSummary for ZC3H13_ZC3H13

check button Fusion gene summary
Fusion gene informationFusion gene name: ZC3H13_ZC3H13
Fusion gene ID: 42566
HgeneTgene
Gene symbol

ZC3H13

ZC3H13

Gene ID

23091

23091

Gene namezinc finger CCCH-type containing 13zinc finger CCCH-type containing 13
SynonymsKIAA0853|XioKIAA0853|Xio
Cytomap

13q14.13

13q14.13

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH domain-containing protein 13zinc finger CCCH domain-containing protein 13
Modification date2018052320180523
UniProtAcc

Q5T200

Q5T200

Ensembl transtripts involved in fusion geneENST00000242848, ENST00000378921, 
ENST00000282007, ENST00000470308, 
ENST00000242848, ENST00000378921, 
ENST00000282007, ENST00000470308, 
Fusion gene scores* DoF score4 X 4 X 3=486 X 7 X 3=126
# samples 57
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZC3H13 [Title/Abstract] AND ZC3H13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA411690ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
ChiTaRS3.1DA779164ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000242848ENST00000242848ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-3CDSENST00000242848ENST00000378921ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-3CDSENST00000242848ENST00000282007ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-intronENST00000242848ENST00000470308ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-3CDSENST00000378921ENST00000242848ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-3CDSENST00000378921ENST00000378921ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-3CDSENST00000378921ENST00000282007ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-intronENST00000378921ENST00000470308ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-3CDSENST00000282007ENST00000242848ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-3CDSENST00000282007ENST00000378921ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-3CDSENST00000282007ENST00000282007ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-intronENST00000282007ENST00000470308ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-3CDSENST00000470308ENST00000242848ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-3CDSENST00000470308ENST00000378921ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-3CDSENST00000470308ENST00000282007ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-intronENST00000470308ENST00000470308ZC3H13chr13

46543985

+ZC3H13chr13

46542016

+
intron-3CDSENST00000242848ENST00000242848ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-3CDSENST00000242848ENST00000378921ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-3CDSENST00000242848ENST00000282007ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-intronENST00000242848ENST00000470308ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-3CDSENST00000378921ENST00000242848ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-3CDSENST00000378921ENST00000378921ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-3CDSENST00000378921ENST00000282007ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-intronENST00000378921ENST00000470308ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-3CDSENST00000282007ENST00000242848ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-3CDSENST00000282007ENST00000378921ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-3CDSENST00000282007ENST00000282007ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-intronENST00000282007ENST00000470308ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-3CDSENST00000470308ENST00000242848ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-3CDSENST00000470308ENST00000378921ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-3CDSENST00000470308ENST00000282007ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-
intron-intronENST00000470308ENST00000470308ZC3H13chr13

46530854

-ZC3H13chr13

46542996

-

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FusionProtFeatures for ZC3H13_ZC3H13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZC3H13

Q5T200

ZC3H13

Q5T200

Associated component of the WMM complex, a complex thatmediates N6-methyladenosine (m6A) methylation of RNAs, amodification that plays a role in the efficiency of mRNA splicingand RNA processing (PubMed:29507755). Acts as a key regulator ofm6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs)pluripotency via its role in m6A methylation (By similarity). Inthe WMM complex, anchors component of the MACOM subcomplex in thenucleus (By similarity). Also required for bridging WTAP to theRNA-binding component RBM15 (RBM15 or RBM15B) (By similarity).{ECO:0000250|UniProtKB:E9Q784}. Associated component of the WMM complex, a complex thatmediates N6-methyladenosine (m6A) methylation of RNAs, amodification that plays a role in the efficiency of mRNA splicingand RNA processing (PubMed:29507755). Acts as a key regulator ofm6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs)pluripotency via its role in m6A methylation (By similarity). Inthe WMM complex, anchors component of the MACOM subcomplex in thenucleus (By similarity). Also required for bridging WTAP to theRNA-binding component RBM15 (RBM15 or RBM15B) (By similarity).{ECO:0000250|UniProtKB:E9Q784}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZC3H13_ZC3H13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZC3H13_ZC3H13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZC3H13_ZC3H13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZC3H13_ZC3H13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource