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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42563

FusionGeneSummary for ZC3H13_MRPS31

check button Fusion gene summary
Fusion gene informationFusion gene name: ZC3H13_MRPS31
Fusion gene ID: 42563
HgeneTgene
Gene symbol

ZC3H13

MRPS31

Gene ID

23091

10240

Gene namezinc finger CCCH-type containing 13mitochondrial ribosomal protein S31
SynonymsKIAA0853|XioIMOGN38|MRP-S31|S31mt
Cytomap

13q14.13

13q14.11

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH domain-containing protein 1328S ribosomal protein S31, mitochondrialimogen 38mitochondrial small ribosomal subunit protein mS31
Modification date2018052320180523
UniProtAcc

Q5T200

Q92665

Ensembl transtripts involved in fusion geneENST00000242848, ENST00000378921, 
ENST00000282007, ENST00000470308, 
ENST00000498078, ENST00000323563, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 1 X 4=16
# samples 54
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZC3H13 [Title/Abstract] AND MRPS31 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-49-AAR0-01AZC3H13chr13

46553948

-MRPS31chr13

41303737

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000242848ENST00000498078ZC3H13chr13

46553948

-MRPS31chr13

41303737

-
5CDS-5UTRENST00000242848ENST00000323563ZC3H13chr13

46553948

-MRPS31chr13

41303737

-
intron-5UTRENST00000378921ENST00000498078ZC3H13chr13

46553948

-MRPS31chr13

41303737

-
intron-5UTRENST00000378921ENST00000323563ZC3H13chr13

46553948

-MRPS31chr13

41303737

-
5CDS-5UTRENST00000282007ENST00000498078ZC3H13chr13

46553948

-MRPS31chr13

41303737

-
5CDS-5UTRENST00000282007ENST00000323563ZC3H13chr13

46553948

-MRPS31chr13

41303737

-
intron-5UTRENST00000470308ENST00000498078ZC3H13chr13

46553948

-MRPS31chr13

41303737

-
intron-5UTRENST00000470308ENST00000323563ZC3H13chr13

46553948

-MRPS31chr13

41303737

-

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FusionProtFeatures for ZC3H13_MRPS31


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZC3H13

Q5T200

MRPS31

Q92665

Associated component of the WMM complex, a complex thatmediates N6-methyladenosine (m6A) methylation of RNAs, amodification that plays a role in the efficiency of mRNA splicingand RNA processing (PubMed:29507755). Acts as a key regulator ofm6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs)pluripotency via its role in m6A methylation (By similarity). Inthe WMM complex, anchors component of the MACOM subcomplex in thenucleus (By similarity). Also required for bridging WTAP to theRNA-binding component RBM15 (RBM15 or RBM15B) (By similarity).{ECO:0000250|UniProtKB:E9Q784}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZC3H13_MRPS31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZC3H13_MRPS31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZC3H13CENPA, MED12, MED13, CCNC, MED25, MED16, MED17, MED1, MED28, MED24, MED23, MED4, MED29, MED8, MED15, MED6, MED14, CDK19, MED30, MED26, POLR2A, POLR2B, MED9, MED19, MED27, MED20, MED21, CDK9, TERF2, BAP1, SIRT7, ALYREF, USP15, WBP11, MAGOH, EIF4A3, CSNK2A1, SCHIP1, YWHAQ, SUZ12, BMI1, ZNF645, KIAA1429, WTAP, KRAS, SRPK2, CLK1, CBR1, ID1, THOC1, KIF26B, MZT1, GAN, U2AF2, ZC3H18, CLK3MRPS31EIF6, LYST, USP42, UBC, ICT1, CUL3, SRPRB, SARNP, FLOT1, CPSF7, ESR2, STAT3, PARK2, SMURF2, GRSF1, MAST3, BTRC, NOL12, TRA2A, RPL6, MRPS2, ZC3H3, RPS8, TRMT10B, ZNF707, MRPS35, MRPS9, MRPS26, PTCD3, MRPS15, MRPS23, MRPS27, MRPS6, MRPS18B, MRPS10, MRPS34, DAP3, MRPS28, MRPS5, MRPS18C, MRPS7, MRPS22, MRPS25, MRPS33, MRPS11, MRPS24, CDK19, MRPS14, MRPS21, HNRNPA1, NANOG, ZNF746, FAM177A1, RRS1, AURKAIP1, ZBTB48, SNRNP70, ZNF331, RPL18, ZNF324B, CCDC59, PDGFB, PPAN, E4F1, BHLHA15, RBM42, ZFC3H1, HNRNPR, ZC3HAV1, RBM3, CFAP20, DLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZC3H13_MRPS31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZC3H13_MRPS31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource