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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42536

FusionGeneSummary for ZBTB7A_TNK1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZBTB7A_TNK1
Fusion gene ID: 42536
HgeneTgene
Gene symbol

ZBTB7A

TNK1

Gene ID

51341

8711

Gene namezinc finger and BTB domain containing 7Atyrosine kinase non receptor 1
SynonymsFBI-1|FBI1|LRF|TIP21|ZBTB7|ZNF857A|pokemon-
Cytomap

19p13.3

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger and BTB domain-containing protein 7AHIV-1 1st-binding protein 1HIV-1 inducer of short transcripts binding proteinPOK erythroid myeloid ontogenic factorPOZ and Krueppel erythroid myeloid ontogenic factorTTF-I-interacting peptide 21factor non-receptor tyrosine-protein kinase TNK1CD38 negative kinase 1
Modification date2018052320180523
UniProtAcc

O95365

Q13470

Ensembl transtripts involved in fusion geneENST00000322357, ENST00000601588, 
ENST00000570896, ENST00000576812, 
ENST00000311668, 
Fusion gene scores* DoF score7 X 8 X 6=3361 X 1 X 1=1
# samples 81
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ZBTB7A [Title/Abstract] AND TNK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNK1

GO:0046777

protein autophosphorylation

10873601


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLAMLTCGA-AB-2938-03AZBTB7Achr19

4055117

-TNK1chr17

7286169

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000322357ENST00000570896ZBTB7Achr19

4055117

-TNK1chr17

7286169

+
intron-5UTRENST00000322357ENST00000576812ZBTB7Achr19

4055117

-TNK1chr17

7286169

+
intron-5UTRENST00000322357ENST00000311668ZBTB7Achr19

4055117

-TNK1chr17

7286169

+
intron-5UTRENST00000601588ENST00000570896ZBTB7Achr19

4055117

-TNK1chr17

7286169

+
intron-5UTRENST00000601588ENST00000576812ZBTB7Achr19

4055117

-TNK1chr17

7286169

+
intron-5UTRENST00000601588ENST00000311668ZBTB7Achr19

4055117

-TNK1chr17

7286169

+

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FusionProtFeatures for ZBTB7A_TNK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZBTB7A

O95365

TNK1

Q13470

Plays a key role in the instruction of early lymphoidprogenitors to develop into B lineage by repressing T-cellinstructive Notch signals (By similarity). Specifically repressesthe transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to theconsensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).{ECO:0000250}. Involved in negative regulation of cell growth. Hastumor suppressor properties. Plays a negative regulatory role inthe Ras-MAPK pathway. May function in signaling pathways utilizedbroadly during fetal development and more selectively in adulttissues and in cells of the lymphohematopoietic system. Couldspecifically be involved in phospholipid signal transduction.{ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZBTB7A_TNK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZBTB7A_TNK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZBTB7AZBTB7A, BCL6, TP53, HDAC1, HDAC2, HDAC3, SIRT1, NCOR1, NCOR2, SIN3A, RB1, BCOR, SP1, AR, TFAP4, EEF1A1, SREBF1, RELA, NFKBIB, NFKBIA, UTP20, SOX2, ZMYND8, ZBTB48, SOX9, HOMEZ, KHDRBS1, UBE2I, ETS1, SMAD4, TRIM25TNK1SFN, TNK1, PLCG1, HSP90AA1, DDX5, ILF3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ, CLTC, GAK, HNRNPA1, HNRNPH2, PDGFRA, MATR3, SEC16A, GTSE1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZBTB7A_TNK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZBTB7A_TNK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZBTB7AC0017636Glioblastoma1CTD_human
HgeneZBTB7AC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneZBTB7AC0033578Prostatic Neoplasms1CTD_human