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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42532

FusionGeneSummary for ZBTB7A_CYP4F3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZBTB7A_CYP4F3
Fusion gene ID: 42532
HgeneTgene
Gene symbol

ZBTB7A

CYP4F3

Gene ID

51341

4051

Gene namezinc finger and BTB domain containing 7Acytochrome P450 family 4 subfamily F member 3
SynonymsFBI-1|FBI1|LRF|TIP21|ZBTB7|ZNF857A|pokemonCPF3|CYP4F|LTB4H
Cytomap

19p13.3

19p13.12

Type of geneprotein-codingprotein-coding
Descriptionzinc finger and BTB domain-containing protein 7AHIV-1 1st-binding protein 1HIV-1 inducer of short transcripts binding proteinPOK erythroid myeloid ontogenic factorPOZ and Krueppel erythroid myeloid ontogenic factorTTF-I-interacting peptide 21factor docosahexaenoic acid omega-hydroxylase CYP4F320-HETE synthase20-hydroxyeicosatetraenoic acid synthaseCYPIVF3cytochrome P-450cytochrome P450 4F3cytochrome P450, family 4, subfamily F, polypeptide 3cytochrome P450, subfamily IVF, polypeptide 3 (leuko
Modification date2018052320180522
UniProtAcc

O95365

Q08477

Ensembl transtripts involved in fusion geneENST00000322357, ENST00000601588, 
ENST00000586182, ENST00000591058, 
ENST00000221307, ENST00000585846, 
ENST00000588886, 
Fusion gene scores* DoF score7 X 8 X 6=3361 X 1 X 1=1
# samples 81
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ZBTB7A [Title/Abstract] AND CYP4F3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-TM-A7CF-01AZBTB7Achr19

4044973

-CYP4F3chr19

15772046

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000322357ENST00000586182ZBTB7Achr19

4044973

-CYP4F3chr19

15772046

+
intron-intronENST00000322357ENST00000591058ZBTB7Achr19

4044973

-CYP4F3chr19

15772046

+
intron-3UTRENST00000322357ENST00000221307ZBTB7Achr19

4044973

-CYP4F3chr19

15772046

+
intron-intronENST00000322357ENST00000585846ZBTB7Achr19

4044973

-CYP4F3chr19

15772046

+
intron-3UTRENST00000322357ENST00000588886ZBTB7Achr19

4044973

-CYP4F3chr19

15772046

+
intron-intronENST00000601588ENST00000586182ZBTB7Achr19

4044973

-CYP4F3chr19

15772046

+
intron-intronENST00000601588ENST00000591058ZBTB7Achr19

4044973

-CYP4F3chr19

15772046

+
intron-3UTRENST00000601588ENST00000221307ZBTB7Achr19

4044973

-CYP4F3chr19

15772046

+
intron-intronENST00000601588ENST00000585846ZBTB7Achr19

4044973

-CYP4F3chr19

15772046

+
intron-3UTRENST00000601588ENST00000588886ZBTB7Achr19

4044973

-CYP4F3chr19

15772046

+

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FusionProtFeatures for ZBTB7A_CYP4F3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZBTB7A

O95365

CYP4F3

Q08477

Plays a key role in the instruction of early lymphoidprogenitors to develop into B lineage by repressing T-cellinstructive Notch signals (By similarity). Specifically repressesthe transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to theconsensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).{ECO:0000250}. Isoform CYP4F3A: Catalyzes the omega-hydroxylation ofleukotriene-B(4), a potent chemoattractant for polymorphonuclearleukocytes, it has low activity for arachidonic acid.{ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:8486631}. Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acidto 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919,PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4)compared with CYP4F3A (PubMed:11461919). Also convertseicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA)(PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acidshydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285).{ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:16820285,ECO:0000269|PubMed:18577768}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZBTB7A_CYP4F3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZBTB7A_CYP4F3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZBTB7AZBTB7A, BCL6, TP53, HDAC1, HDAC2, HDAC3, SIRT1, NCOR1, NCOR2, SIN3A, RB1, BCOR, SP1, AR, TFAP4, EEF1A1, SREBF1, RELA, NFKBIB, NFKBIA, UTP20, SOX2, ZMYND8, ZBTB48, SOX9, HOMEZ, KHDRBS1, UBE2I, ETS1, SMAD4, TRIM25CYP4F3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZBTB7A_CYP4F3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZBTB7A_CYP4F3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZBTB7AC0017636Glioblastoma1CTD_human
HgeneZBTB7AC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneZBTB7AC0033578Prostatic Neoplasms1CTD_human