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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42494

FusionGeneSummary for ZBTB25_NME9

check button Fusion gene summary
Fusion gene informationFusion gene name: ZBTB25_NME9
Fusion gene ID: 42494
HgeneTgene
Gene symbol

ZBTB25

NME9

Gene ID

7597

347736

Gene namezinc finger and BTB domain containing 25NME/NM23 family member 9
SynonymsC14orf51|KUP|ZNF46NM23-H9|TXL-2|TXL2|TXNDC6
Cytomap

14q23.3

3q22.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger and BTB domain-containing protein 25zinc finger protein 46zinc finger protein KUPthioredoxin domain-containing protein 6NME gene family member 9thioredoxin-like protein 2
Modification date2018052320180402
UniProtAcc

P24278

Q86XW9

Ensembl transtripts involved in fusion geneENST00000555220, ENST00000555424, 
ENST00000608382, ENST00000394715, 
ENST00000317876, ENST00000383180, 
ENST00000536478, ENST00000341790, 
ENST00000484930, ENST00000333911, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 3=27
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZBTB25 [Title/Abstract] AND NME9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA452527ZBTB25chr14

64945096

-NME9chr3

138016452

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000555220ENST00000317876ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000555220ENST00000383180ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000555220ENST00000536478ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000555220ENST00000341790ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000555220ENST00000484930ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000555220ENST00000333911ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000555424ENST00000317876ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000555424ENST00000383180ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000555424ENST00000536478ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000555424ENST00000341790ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000555424ENST00000484930ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000555424ENST00000333911ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000608382ENST00000317876ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000608382ENST00000383180ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000608382ENST00000536478ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000608382ENST00000341790ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000608382ENST00000484930ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000608382ENST00000333911ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000394715ENST00000317876ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000394715ENST00000383180ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000394715ENST00000536478ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000394715ENST00000341790ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000394715ENST00000484930ZBTB25chr14

64945096

-NME9chr3

138016452

+
intron-intronENST00000394715ENST00000333911ZBTB25chr14

64945096

-NME9chr3

138016452

+

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FusionProtFeatures for ZBTB25_NME9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZBTB25

P24278

NME9

Q86XW9

May be involved in transcriptional regulation. May be a regulator of microtubule physiology.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZBTB25_NME9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZBTB25_NME9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZBTB25_NME9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZBTB25_NME9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource