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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42479

FusionGeneSummary for ZBTB20_PGD

check button Fusion gene summary
Fusion gene informationFusion gene name: ZBTB20_PGD
Fusion gene ID: 42479
HgeneTgene
Gene symbol

ZBTB20

PGD

Gene ID

26137

26227

Gene namezinc finger and BTB domain containing 20phosphoglycerate dehydrogenase
SynonymsDPZF|HOF|ODA-8S|PRIMS|ZNF2883-PGDH|3PGDH|HEL-S-113|NLS|NLS1|PDG|PGAD|PGD|PGDH|PHGDHD|SERA
Cytomap

3q13.31

1p12

Type of geneprotein-codingprotein-coding
Descriptionzinc finger and BTB domain-containing protein 20BTB/POZ zinc finger protein DPZFdendritic cell-derived BTB/POZ zinc fingerzinc finger protein 288D-3-phosphoglycerate dehydrogenase2-oxoglutarate reductase3-phosphoglycerate dehydrogenaseepididymis secretory protein Li 113malate dehydrogenase
Modification date2018052620180523
UniProtAcc

Q9HC78

P52209

Ensembl transtripts involved in fusion geneENST00000462705, ENST00000393785, 
ENST00000481632, ENST00000471418, 
ENST00000357258, ENST00000464560, 
ENST00000488663, ENST00000474710, 
ENST00000541529, ENST00000270776, 
ENST00000538557, ENST00000498356, 
Fusion gene scores* DoF score24 X 12 X 15=43205 X 4 X 5=100
# samples 335
** MAII scorelog2(33/4320*10)=-3.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZBTB20 [Title/Abstract] AND PGD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-EA-A1QS-01AZBTB20chr3

114519948

-PGDchr1

10479474

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000462705ENST00000541529ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000462705ENST00000270776ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000462705ENST00000538557ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3UTRENST00000462705ENST00000498356ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000393785ENST00000541529ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000393785ENST00000270776ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000393785ENST00000538557ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3UTRENST00000393785ENST00000498356ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000481632ENST00000541529ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000481632ENST00000270776ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000481632ENST00000538557ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3UTRENST00000481632ENST00000498356ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000471418ENST00000541529ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000471418ENST00000270776ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000471418ENST00000538557ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3UTRENST00000471418ENST00000498356ZBTB20chr3

114519948

-PGDchr1

10479474

+
5UTR-3CDSENST00000357258ENST00000541529ZBTB20chr3

114519948

-PGDchr1

10479474

+
5UTR-3CDSENST00000357258ENST00000270776ZBTB20chr3

114519948

-PGDchr1

10479474

+
5UTR-3CDSENST00000357258ENST00000538557ZBTB20chr3

114519948

-PGDchr1

10479474

+
5UTR-3UTRENST00000357258ENST00000498356ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000464560ENST00000541529ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000464560ENST00000270776ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000464560ENST00000538557ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3UTRENST00000464560ENST00000498356ZBTB20chr3

114519948

-PGDchr1

10479474

+
5UTR-3CDSENST00000488663ENST00000541529ZBTB20chr3

114519948

-PGDchr1

10479474

+
5UTR-3CDSENST00000488663ENST00000270776ZBTB20chr3

114519948

-PGDchr1

10479474

+
5UTR-3CDSENST00000488663ENST00000538557ZBTB20chr3

114519948

-PGDchr1

10479474

+
5UTR-3UTRENST00000488663ENST00000498356ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000474710ENST00000541529ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000474710ENST00000270776ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3CDSENST00000474710ENST00000538557ZBTB20chr3

114519948

-PGDchr1

10479474

+
intron-3UTRENST00000474710ENST00000498356ZBTB20chr3

114519948

-PGDchr1

10479474

+

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FusionProtFeatures for ZBTB20_PGD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZBTB20

Q9HC78

PGD

P52209

May be a transcription factor that may be involved inhematopoiesis, oncogenesis, and immune responses(PubMed:11352661). Plays a role in postnatal myogenesis, may beinvolved in the regulation of satellite cells self-renewal (Bysimilarity). {ECO:0000250|UniProtKB:Q8K0L9,ECO:0000269|PubMed:11352661}. Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), withconcomitant reduction of NADP to NADPH. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZBTB20_PGD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZBTB20_PGD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZBTB20NR3C1, PPARG, CHD7, ELAVL1, HSP90AA1, FLNA, MYH9, IQGAP1, SYNPO, LIMA1, ANLN, MYO19PGDLSM8, USPL1, ISG15, TERF1, CDK2, IQCB1, CDK4, ALDH7A1, ALDH9A1, EEF2, GLA, GNAI3, HMGB2, AHSA1, C12orf10, CHORDC1, EIF4H, G6PD, LDHA, LDHB, NDRG1, PDIA3, SORD, TCEA1, TGM2, THOP1, YWHAB, YWHAG, YWHAQ, RPS6KA1, TXNDC5, WWOX, MOV10, NXF1, FABP5, GDI1, P4HB, ACAA2, CDV3, CTSL, EZR, ISYNA1, MSN, NCBP1, RDX, SUMO2, TAGLN, UCHL3, SUMO3, TALDO1, CEP290, OFD1, RBM8A, CDC73, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZBTB20_PGD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePGDP52209DB00920Ketotifen6-phosphogluconate dehydrogenase, decarboxylatingsmall moleculeapproved
TgenePGDP52209DB00851Dacarbazine6-phosphogluconate dehydrogenase, decarboxylatingsmall moleculeapproved|investigational

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RelatedDiseases for ZBTB20_PGD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZBTB20C0038356Stomach Neoplasms1CTD_human
HgeneZBTB20C0796121Primrose syndrome1CTD_human;ORPHANET;UNIPROT
TgenePGDC2239176Liver carcinoma1CTD_human