FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42478

FusionGeneSummary for ZBTB20_NAMPT

check button Fusion gene summary
Fusion gene informationFusion gene name: ZBTB20_NAMPT
Fusion gene ID: 42478
HgeneTgene
Gene symbol

ZBTB20

NAMPT

Gene ID

26137

10135

Gene namezinc finger and BTB domain containing 20nicotinamide phosphoribosyltransferase
SynonymsDPZF|HOF|ODA-8S|PRIMS|ZNF2881110035O14Rik|PBEF|PBEF1|VF|VISFATIN
Cytomap

3q13.31

7q22.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger and BTB domain-containing protein 20BTB/POZ zinc finger protein DPZFdendritic cell-derived BTB/POZ zinc fingerzinc finger protein 288nicotinamide phosphoribosyltransferaseNAmPRTasepre-B cell-enhancing factorpre-B-cell colony-enhancing factor 1
Modification date2018052620180519
UniProtAcc

Q9HC78

P43490

Ensembl transtripts involved in fusion geneENST00000462705, ENST00000393785, 
ENST00000481632, ENST00000471418, 
ENST00000357258, ENST00000464560, 
ENST00000488663, ENST00000474710, 
ENST00000222553, ENST00000354289, 
ENST00000484527, 
Fusion gene scores* DoF score24 X 12 X 15=43205 X 5 X 2=50
# samples 335
** MAII scorelog2(33/4320*10)=-3.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: ZBTB20 [Title/Abstract] AND NAMPT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNAMPT

GO:0008286

insulin receptor signaling pathway

17983582

TgeneNAMPT

GO:0045944

positive regulation of transcription by RNA polymerase II

23001182

TgeneNAMPT

GO:0051770

positive regulation of nitric-oxide synthase biosynthetic process

19727662

TgeneNAMPT

GO:0060612

adipose tissue development

17983582


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ355873ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000462705ENST00000222553ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000462705ENST00000354289ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000462705ENST00000484527ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000393785ENST00000222553ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000393785ENST00000354289ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000393785ENST00000484527ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000481632ENST00000222553ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000481632ENST00000354289ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000481632ENST00000484527ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000471418ENST00000222553ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000471418ENST00000354289ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000471418ENST00000484527ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000357258ENST00000222553ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000357258ENST00000354289ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000357258ENST00000484527ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000464560ENST00000222553ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000464560ENST00000354289ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000464560ENST00000484527ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000488663ENST00000222553ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000488663ENST00000354289ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000488663ENST00000484527ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000474710ENST00000222553ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000474710ENST00000354289ZBTB20chr3

114424139

+NAMPTchr7

105891952

-
intron-intronENST00000474710ENST00000484527ZBTB20chr3

114424139

+NAMPTchr7

105891952

-

Top

FusionProtFeatures for ZBTB20_NAMPT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZBTB20

Q9HC78

NAMPT

P43490

May be a transcription factor that may be involved inhematopoiesis, oncogenesis, and immune responses(PubMed:11352661). Plays a role in postnatal myogenesis, may beinvolved in the regulation of satellite cells self-renewal (Bysimilarity). {ECO:0000250|UniProtKB:Q8K0L9,ECO:0000269|PubMed:11352661}. Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamidemononucleotide, an intermediate in the biosynthesis of NAD. It isthe rate limiting component in the mammalian NAD biosynthesispathway. The secreted form behaves both as a cytokine withimmunomodulating properties and an adipokine with anti-diabeticproperties, it has no enzymatic activity, partly because of lackof activation by ATP, which has a low level in extracellular spaceand plasma. Plays a role in the modulation of circadian clockfunction. NAMPT-dependent oscillatory production of NAD regulatesoscillation of clock target gene expression by releasing the coreclock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependentSIRT1-mediated suppression (By similarity).{ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZBTB20_NAMPT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZBTB20_NAMPT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZBTB20_NAMPT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZBTB20_NAMPT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZBTB20C0038356Stomach Neoplasms1CTD_human
HgeneZBTB20C0796121Primrose syndrome1CTD_human;ORPHANET;UNIPROT
TgeneNAMPTC0009319Colitis1CTD_human
TgeneNAMPTC0009404Colorectal Neoplasms1CTD_human
TgeneNAMPTC0028754Obesity1CTD_human
TgeneNAMPTC0162820Dermatitis, Allergic Contact1CTD_human