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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42470

FusionGeneSummary for ZBTB20_EPHA6

check button Fusion gene summary
Fusion gene informationFusion gene name: ZBTB20_EPHA6
Fusion gene ID: 42470
HgeneTgene
Gene symbol

ZBTB20

EPHA6

Gene ID

26137

285220

Gene namezinc finger and BTB domain containing 20EPH receptor A6
SynonymsDPZF|HOF|ODA-8S|PRIMS|ZNF288EHK-2|EHK2|EK12|EPA6|HEK12|PRO57066
Cytomap

3q13.31

3q11.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger and BTB domain-containing protein 20BTB/POZ zinc finger protein DPZFdendritic cell-derived BTB/POZ zinc fingerzinc finger protein 288ephrin type-A receptor 6EPH homology kinase 2EPH-like kinase 12ephrin receptor EphA6
Modification date2018052620180523
UniProtAcc

Q9HC78

Q9UF33

Ensembl transtripts involved in fusion geneENST00000462705, ENST00000393785, 
ENST00000481632, ENST00000471418, 
ENST00000357258, ENST00000464560, 
ENST00000488663, ENST00000474710, 
ENST00000470610, ENST00000389672, 
ENST00000542517, ENST00000514100, 
ENST00000502694, ENST00000442602, 
Fusion gene scores* DoF score24 X 12 X 15=43208 X 8 X 4=256
# samples 338
** MAII scorelog2(33/4320*10)=-3.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZBTB20 [Title/Abstract] AND EPHA6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-78-7162-01AZBTB20chr3

114219199

-EPHA6chr3

97439105

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000462705ENST00000470610ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000462705ENST00000389672ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000462705ENST00000542517ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000462705ENST00000514100ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000462705ENST00000502694ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000462705ENST00000442602ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000393785ENST00000470610ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000393785ENST00000389672ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000393785ENST00000542517ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000393785ENST00000514100ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000393785ENST00000502694ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000393785ENST00000442602ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000481632ENST00000470610ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000481632ENST00000389672ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000481632ENST00000542517ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000481632ENST00000514100ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000481632ENST00000502694ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000481632ENST00000442602ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000471418ENST00000470610ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000471418ENST00000389672ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000471418ENST00000542517ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000471418ENST00000514100ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000471418ENST00000502694ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000471418ENST00000442602ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000357258ENST00000470610ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000357258ENST00000389672ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000357258ENST00000542517ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000357258ENST00000514100ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000357258ENST00000502694ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000357258ENST00000442602ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000464560ENST00000470610ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000464560ENST00000389672ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000464560ENST00000542517ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000464560ENST00000514100ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000464560ENST00000502694ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
5UTR-intronENST00000464560ENST00000442602ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
intron-intronENST00000488663ENST00000470610ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
intron-intronENST00000488663ENST00000389672ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
intron-intronENST00000488663ENST00000542517ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
intron-intronENST00000488663ENST00000514100ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
intron-intronENST00000488663ENST00000502694ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
intron-intronENST00000488663ENST00000442602ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
intron-intronENST00000474710ENST00000470610ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
intron-intronENST00000474710ENST00000389672ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
intron-intronENST00000474710ENST00000542517ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
intron-intronENST00000474710ENST00000514100ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
intron-intronENST00000474710ENST00000502694ZBTB20chr3

114219199

-EPHA6chr3

97439105

+
intron-intronENST00000474710ENST00000442602ZBTB20chr3

114219199

-EPHA6chr3

97439105

+

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FusionProtFeatures for ZBTB20_EPHA6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZBTB20

Q9HC78

EPHA6

Q9UF33

May be a transcription factor that may be involved inhematopoiesis, oncogenesis, and immune responses(PubMed:11352661). Plays a role in postnatal myogenesis, may beinvolved in the regulation of satellite cells self-renewal (Bysimilarity). {ECO:0000250|UniProtKB:Q8K0L9,ECO:0000269|PubMed:11352661}. Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells,leading to contact-dependent bidirectional signaling intoneighboring cells. The signaling pathway downstream of thereceptor is referred to as forward signaling while the signalingpathway downstream of the ephrin ligand is referred to as reversesignaling (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZBTB20_EPHA6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZBTB20_EPHA6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZBTB20NR3C1, PPARG, CHD7, ELAVL1, HSP90AA1, FLNA, MYH9, IQGAP1, SYNPO, LIMA1, ANLN, MYO19EPHA6GPHA2, PROC, DEFA5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZBTB20_EPHA6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZBTB20_EPHA6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZBTB20C0038356Stomach Neoplasms1CTD_human
HgeneZBTB20C0796121Primrose syndrome1CTD_human;ORPHANET;UNIPROT