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Fusion gene ID: 42415 |
FusionGeneSummary for YWHAQ_ADAM17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: YWHAQ_ADAM17 | Fusion gene ID: 42415 | Hgene | Tgene | Gene symbol | YWHAQ | ADAM17 | Gene ID | 10971 | 6868 |
| Gene name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta | ADAM metallopeptidase domain 17 | |
| Synonyms | 14-3-3|1C5|HS1 | ADAM18|CD156B|CSVP|NISBD|NISBD1|TACE | |
| Cytomap | 2p25.1 | 2p25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 14-3-3 protein theta14-3-3 protein T-cell14-3-3 protein tau14-3-3 thetaprotein, thetatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | disintegrin and metalloproteinase domain-containing protein 17ADAM metallopeptidase domain 18TNF-alpha convertaseTNF-alpha converting enzymesnake venom-like proteasetumor necrosis factor, alpha, converting enzyme | |
| Modification date | 20180522 | 20180520 | |
| UniProtAcc | P27348 | P78536 | |
| Ensembl transtripts involved in fusion gene | ENST00000381844, ENST00000238081, ENST00000474715, | ENST00000310823, ENST00000497134, | |
| Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 2 X 2 X 2=8 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: YWHAQ [Title/Abstract] AND ADAM17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | YWHAQ | GO:0045892 | negative regulation of transcription, DNA-templated | 15163635 |
| Tgene | ADAM17 | GO:0001666 | response to hypoxia | 18276953 |
| Tgene | ADAM17 | GO:0006508 | proteolysis | 24227843 |
| Tgene | ADAM17 | GO:0006509 | membrane protein ectodomain proteolysis | 9034190|9574564|17786981|18676862 |
| Tgene | ADAM17 | GO:0007155 | cell adhesion | 14970227 |
| Tgene | ADAM17 | GO:0007173 | epidermal growth factor receptor signaling pathway | 12743035 |
| Tgene | ADAM17 | GO:0007220 | Notch receptor processing | 24226769 |
| Tgene | ADAM17 | GO:0031659 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | 18483258 |
| Tgene | ADAM17 | GO:0032496 | response to lipopolysaccharide | 18383040 |
| Tgene | ADAM17 | GO:0033627 | cell adhesion mediated by integrin | 14970227 |
| Tgene | ADAM17 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 24813629 |
| Tgene | ADAM17 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | 18483258 |
| Tgene | ADAM17 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis | 14625290|15691827|17010968 |
| Tgene | ADAM17 | GO:0071403 | cellular response to high density lipoprotein particle stimulus | 17786981 |
| Tgene | ADAM17 | GO:1905564 | positive regulation of vascular endothelial cell proliferation | 24813629 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-18-4086-01A | YWHAQ | chr2 | 9770288 | - | ADAM17 | chr2 | 9650260 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000381844 | ENST00000310823 | YWHAQ | chr2 | 9770288 | - | ADAM17 | chr2 | 9650260 | - |
| 5CDS-intron | ENST00000381844 | ENST00000497134 | YWHAQ | chr2 | 9770288 | - | ADAM17 | chr2 | 9650260 | - |
| Frame-shift | ENST00000238081 | ENST00000310823 | YWHAQ | chr2 | 9770288 | - | ADAM17 | chr2 | 9650260 | - |
| 5CDS-intron | ENST00000238081 | ENST00000497134 | YWHAQ | chr2 | 9770288 | - | ADAM17 | chr2 | 9650260 | - |
| intron-3CDS | ENST00000474715 | ENST00000310823 | YWHAQ | chr2 | 9770288 | - | ADAM17 | chr2 | 9650260 | - |
| intron-intron | ENST00000474715 | ENST00000497134 | YWHAQ | chr2 | 9770288 | - | ADAM17 | chr2 | 9650260 | - |
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FusionProtFeatures for YWHAQ_ADAM17 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| YWHAQ | ADAM17 |
| Adapter protein implicated in the regulation of a largespectrum of both general and specialized signaling pathways. Bindsto a large number of partners, usually by recognition of aphosphoserine or phosphothreonine motif. Binding generally resultsin the modulation of the activity of the binding partner.Negatively regulates the kinase activity of PDPK1.{ECO:0000269|PubMed:12177059}. | Cleaves the membrane-bound precursor of TNF-alpha to itsmature soluble form. Responsible for the proteolytical release ofsoluble JAM3 from endothelial cells surface. Responsible for theproteolytic release of several other cell-surface proteins,including p75 TNF-receptor, interleukin 1 receptor type II, p55TNF-receptor, transforming growth factor-alpha, L-selectin, growthhormone receptor, MUC1 and the amyloid precursor protein. Acts asan activator of Notch pathway by mediating cleavage of Notch,generating the membrane-associated intermediate fragment calledNotch extracellular truncation (NEXT). Plays a role in theproteolytic processing of ACE2. {ECO:0000269|PubMed:12441351,ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769,ECO:0000269|PubMed:24227843}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ADAM17 | chr2:9770288 | chr2:9650260 | ENST00000310823 | - | 9 | 19 | 564_602 | 397 | 825 | Compositional bias | Note=Cys-rich |
| Tgene | >ADAM17 | chr2:9770288 | chr2:9650260 | ENST00000310823 | - | 9 | 19 | 475_563 | 397 | 825 | Domain | Disintegrin |
| Tgene | >ADAM17 | chr2:9770288 | chr2:9650260 | ENST00000310823 | - | 9 | 19 | 731_738 | 397 | 825 | Motif | SH3-binding |
| Tgene | >ADAM17 | chr2:9770288 | chr2:9650260 | ENST00000310823 | - | 9 | 19 | 741_748 | 397 | 825 | Motif | SH3-binding |
| Tgene | >ADAM17 | chr2:9770288 | chr2:9650260 | ENST00000310823 | - | 9 | 19 | 603_671 | 397 | 825 | Region | Note=Crambin-like |
| Tgene | >ADAM17 | chr2:9770288 | chr2:9650260 | ENST00000310823 | - | 9 | 19 | 693_824 | 397 | 825 | Topological domain | Cytoplasmic |
| Tgene | >ADAM17 | chr2:9770288 | chr2:9650260 | ENST00000310823 | - | 9 | 19 | 672_692 | 397 | 825 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ADAM17 | chr2:9770288 | chr2:9650260 | ENST00000310823 | - | 9 | 19 | 96_99 | 397 | 825 | Compositional bias | Note=Poly-Val |
| Tgene | ADAM17 | chr2:9770288 | chr2:9650260 | ENST00000310823 | - | 9 | 19 | 223_474 | 397 | 825 | Domain | Peptidase M12B |
| Tgene | ADAM17 | chr2:9770288 | chr2:9650260 | ENST00000310823 | - | 9 | 19 | 182_189 | 397 | 825 | Motif | Cysteine switch |
| Tgene | ADAM17 | chr2:9770288 | chr2:9650260 | ENST00000310823 | - | 9 | 19 | 215_671 | 397 | 825 | Topological domain | Extracellular |
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FusionGeneSequence for YWHAQ_ADAM17 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_YWHAQ_ENST00000381844_chr2_9770288_-_ADAM17_ENST00000310823_chr2_9650260_-_526aa MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESEL RSICTTVLEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCG NSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLD LGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQL SINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_YWHAQ_ENST00000381844_chr2_9770288_-_ADAM17_ENST00000310823_chr2_9650260_-_1578nt ATGGAGAAGACTGAGCTGATCCAGAAGGCCAAGCTGGCCGAGCAGGCCGAGCGCTACGACGACATGGCCACCTGCATGAAGGCAGTGACC GAGCAGGGCGCCGAGCTGTCCAACGAGGAGCGCAACCTGCTCTCCGTGGCCTACAAGAACGTGGTCGGGGGCCGCAGGTCCGCCTGGAGG GTCATCTCTAGCATCGAGCAGAAGACCGACACCTCCGACAAGAAGTTGCAGCTGATTAAGGACTATCGGGAGAAAGTGGAGTCCGAGCTG AGATCCATCTGCACCACGGTGCTGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGCAAATGTGAGAAACGAGTACAGGATGTAATTGAACGATTTTGGGATTTCATTGACCAGCTG AGCATCAATACTTTTGGAAAGTTTTTAGCAGACAACATCGTTGGGTCTGTCCTGGTTTTCTCCTTGATATTTTGGATTCCTTTCAGCATT CTTGTCCATTGTGTGGATAAGAAATTGGATAAACAGTATGAATCTCTGTCTCTGTTTCACCCCAGTAACGTCGAAATGCTGAGCAGCATG GATTCTGCATCGGTTCGCATTATCAAACCCTTTCCTGCGCCCCAGACTCCAGGCCGCCTGCAGCCTGCCCCTGTGATCCCTTCGGCGCCA GCAGCTCCAAAACTGGACCACCAGAGAATGGACACCATCCAGGAAGACCCCAGCACAGACTCACATATGGACGAGGATGGGTTTGAGAAG GACCCCTTCCCAAATAGCAGCACAGCTGCCAAGTCATTTGAGGATCTCACGGACCATCCGGTCACCAGAAGTGAAAAGGCTGCCTCCTTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_YWHAQ_ENST00000381844_chr2_9770288_-_ADAM17_ENST00000310823_chr2_9650260_-_3433nt AAAAGCGGGCGGCGGGCCGCATTGTCTGACGGCGCTCCCTCTCTGCTTTTTGTTCTCGCCTCGCCGCCCCGCCCCTCCGCAGCTCTCGAG GCTCCTCCCGCTGCGGGTCGGCGCTCGCCCTCGCTCTCCTCGCCCTCCGCCCCGGCCCCGGCCCCGCGCCCGCCATGGAGAAGACTGAGC TGATCCAGAAGGCCAAGCTGGCCGAGCAGGCCGAGCGCTACGACGACATGGCCACCTGCATGAAGGCAGTGACCGAGCAGGGCGCCGAGC TGTCCAACGAGGAGCGCAACCTGCTCTCCGTGGCCTACAAGAACGTGGTCGGGGGCCGCAGGTCCGCCTGGAGGGTCATCTCTAGCATCG AGCAGAAGACCGACACCTCCGACAAGAAGTTGCAGCTGATTAAGGACTATCGGGAGAAAGTGGAGTCCGAGCTGAGATCCATCTGCACCA CGGTGCTGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGTCTAGCAGAATGTGCCC CGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATGTTTTCAAACTGCAGTA AACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGGAACTCGAGGGTGGATG AAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAGGAAGGTGTCCAGTGCA GTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAATGCTACTTGCAAAGGCG TGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGATCTTGGCAAGTGTAAGG ATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCCTGCAAGGTGTGCTGCA GGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCCTGTACAGTAGGATTTT GTGACATGAATGGCAAATGTGAGAAACGAGTACAGGATGTAATTGAACGATTTTGGGATTTCATTGACCAGCTGAGCATCAATACTTTTG GAAAGTTTTTAGCAGACAACATCGTTGGGTCTGTCCTGGTTTTCTCCTTGATATTTTGGATTCCTTTCAGCATTCTTGTCCATTGTGTGG ATAAGAAATTGGATAAACAGTATGAATCTCTGTCTCTGTTTCACCCCAGTAACGTCGAAATGCTGAGCAGCATGGATTCTGCATCGGTTC GCATTATCAAACCCTTTCCTGCGCCCCAGACTCCAGGCCGCCTGCAGCCTGCCCCTGTGATCCCTTCGGCGCCAGCAGCTCCAAAACTGG ACCACCAGAGAATGGACACCATCCAGGAAGACCCCAGCACAGACTCACATATGGACGAGGATGGGTTTGAGAAGGACCCCTTCCCAAATA GCAGCACAGCTGCCAAGTCATTTGAGGATCTCACGGACCATCCGGTCACCAGAAGTGAAAAGGCTGCCTCCTTTAAACTGCAGCGTCAGA ATCGTGTTGACAGCAAAGAAACAGAGTGCTAATTTAGTTCTCAGCTCTTCTGACTTAAGTGTGCAAAATATTTTTATAGATTTGACCTAC AAATCAATCACAGCTTGTATTTTGTGAAGACTGGGAAGTGACTTAGCAGATGCTGGTCATGTGTTTGAACTTCCTGCAGGTAAACAGTTC TTGTGTGGTTTGGCCCTTCTCCTTTTGAAAAGGTAAGGTGAAGGTGAATCTAGCTTATTTTGAGGCTTTCAGGTTTTAGTTTTTAAAATA TCTTTTGACCTGTGGTGCAAAAGCAGAAAATACAGCTGGATTGGGTTATGAATATTTACGTTTTTGTAAATTAATCTTTTATATTGATAA CAGCACTGACTAGGGAAATGATCAGTTTTTTTTTATACACTGTAATGAACCGCTGAATATGAGGCATTTGGCATTTATTTGTGATGACAA CTGGAATAGTTTTTTTTTTTTTTTTTTTTTTTTGCCTTCAACTAAAAACAAAGGAGATAAATCTAGTATACATTGTCTCTAAATTGTGGG TCTATTTCTAGTTATTACCCAGAGTTTTTATGTAGCAGGGAAAATATATATCTAAATTTAGAAATCATTTGGGTTAATATGGCTCTTCAT AATTCTAAGACTAATGCTCTCTAGAAACCTAACCACCTACCTTACAGTGAGGGCTATACATGGTAGCCAGTTGAATTTATGGAATCTACC AACTGTTTAGGGCCCTGATTTGCTGGGCAGTTTTTCTGTATTTTATAAGTATCTTCATGTATCCCTGTTACTGATAGGGATACATGCTCT TAGAAAATTCACTATTGGCTGGGAGTGGTGGCTCATGCCTGTAATCCCAGCACTTGGAGAGGCTGAGGTTGCGCCACTACACTCCAGCCT GGGTGACAGAGTGAGACTCTGCCTCAAAAAAAAAAAAAAAAAAAAAAAATTCACTATCTACAAACCTAGAATATTTAAAATACAAAGATT GCCTGTTTTCAAACACTATTGAATAAGAGGGTGAGATATTTCTTAACAACAACAACAACAAAAAAAACAGGTTGTTTTGAATGTGATGAG CCAGCCAGGAGATAGAATACTACCTGCCCTTAGGGTTGGGGGCTGTCCCCACAAGACTTGATACTTCAGAAACCCTTTTTATTGACCCAC AAGCAGATATTTGAATTACTTCTTACTTTATTGCTCCAGGATTCTGGATGGGCTGCATTTACTGTGTGAAGGATAAAAATCATTAGCCTG GATTCTGATTTCTATAAATTGCCATTAAAAGCTTTTTTTCCCCTAAGAACTGAAATGTGCTCACCAGCCAAAACATTTTAACTTGTAAAT TTTGAGGGCAGTTAACCAAACCTGTGACTAATCATATCTCCTCCTACCCCCCATTTCCAAGGACATTTGTTACTCAGATACTTGTTATAC TAATACTTGAACTTGTACCTTATGGTATTTGCTATCTTTTAACTAGTCATGATATTCTTATACTTTAGTTACACTTTTGGAATTTGATAC AAGGTTGAGTGGGGTGTGTGGGTGTATGTATGAGTGAAACAGTTCTCAAAAGAATGTAAGAAAAACCATTTTTATAAAATTGTGACTTTT TAAAAACATAGTCTTTGTCATTTATAGAATTAACAAGCTGCTCAGGGTATATTTTATAGCTGTAGCACTGATATCTGCATTAATAAATAC |
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FusionGenePPI for YWHAQ_ADAM17 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| YWHAQ | MEF2D, BAD, CRTC2, KIF5B, PI4KB, SAMD4B, KIF5C, MPRIP, KLC4, BRAF, PNKP, EPB41L3, TJP2, CALML5, PAK4, UNC79, CBWD2, RAI14, MARK2, SPIRE1, RAF1, EDC3, EML3, IRS2, KIAA0930, RASGRP3, MLLT4, RABEP1, USP8, LUC7L2, TSC2, KIF23, SRSF3, DDX6, MARK3, FAM83G, SUV420H1, DENND4A, PAK6, SRSF1, SRSF10, EPB41L2, PPFIBP1, RPL21, SH3BP4, SRSF6, HDAC5, LARP1, KLC2, PANK2, NIF3L1, ARHGEF2, FXYD1, PFKFB2, CCAR1, NRIP1, AR, ESR1, ESR2, THRA, MED1, NCOA3, NCOA1, REM1, CBL, BAX, YAP1, PRKD1, KRT18, DAPK1, CDKN1B, PRKCZ, PDPK1, CDC25B, TERT, LYST, UCP2, UCP3, CDK16, MDM2, YWHAE, HDAC7, E2F1, ING1, HDAC4, CAMK2A, HIST2H3C, EMD, SAMSN1, CHAF1A, MYC, H1F0, HIST1H1D, HIST1H1T, H2AFX, HIST1H2AK, HIST1H2BD, HIST1H4A, NPM1, TGIF2LY, HNRNPC, HNRNPA2B1, RALY, RPS3, P3H4, CACNA1S, ATP5A1, USP42, HIST1H1C, MYL12B, TTN, CALM1, CEP250, MYLK2, YWHAZ, YWHAG, YWHAH, BANK1, VIM, LMNA, ACTN2, DES, VASP, MYH2, MYH7, MYH9, MYH11, MYH13, MYL3, ACTA2, ACTG1, ACTB, TUBB2A, ANKRD18A, KRT8, KRT17, TPM1, EEF1A1, ATP5B, CPS1, HMGCS2, TUT1, SFN, YWHAB, PRKDC, WNK4, TUBA1C, HSPB1, HSPA8, KRT1, KRT9, MAGOH, EIF4A3, TUBA3C, ADORA3, ADCK2, CDC5L, DISC1, CABIN1, OPTN, PCK1, EXO1, ARRB1, ARRB2, ABL1, MPL, PDE3B, HDAC3, CDKN1A, PSMA3, NEDD4L, ZNRF2, ZNRF1, CUL3, CUL2, CDK2, NEDD8, ZHX2, PRKCQ, RNF11, RPTOR, PKP2, DAB2IP, MAP3K5, FSHR, MDM4, MAP3K1, UBQLN4, LCK, SIK2, LRRK2, GRK5, CRK, WWTR1, SNCA, VCP, FN1, GRB2, TRIM32, SMURF1, RNF20, MYCBP2, HECTD1, CAMKK1, PDE3A, TH, TPD52L2, MFF, TPD52, WDR20, TPD52L1, GIGYF1, RAE1, CDK18, MYCBP, RMDN3, WNK1, UPF1, WASF2, PLEKHA7, TFEB, SIPA1L3, ARHGAP23, SPEG, CEP170, TBC1D4, AKT1S1, NOS2, SMAD9, CDC25C, ZFP36, TNF, ZBTB17, MST1R, BAG3, EFNB1, ULK4, FBLN1, NFKB1, SSFA2, KIF1C, RCOR3, SSX2IP, CDK11B, CLTC, MRPS27, ZC3H13, WTAP, KIAA1429, LMO7, TRIM28, NFATC1, CSE1L, TCP1, TPI1, PDXK, ENO1, AHCY, PKM, PANK1, SPR, LDHA, CKM, GAPDH, PGK1, HADHA, SLC27A2, ACSL4, FASN, PFKL, CFL1, PFN1, TLN1, CBLL1, SPTB, SPTA1, FSCN1, ANXA1, ANXA2, LMNB1, TUBB, TUBA1A, DYNC1H1, GCN1L1, PABPC4, PABPN1, AARS2, LARS2, IARS2, VARS, RPL10A, RPL7, RPLP2, RPL15, RPL19, RPLP0, DCPS, RNASE2, DHX9, DDX3X, DDX1, HNRNPK, HNRNPA1, HNRNPH1, HNRNPF, RUVBL2, DNMT1, HIST1H2BG, HIST2H4A, HAT1, SSBP1, NME7, NADK, CTPS1, WWC2, BCAP31, PDCD6, HUS1, PRDX1, WWP1, COPS4, PSME3, NCL, NOLC1, APC, PTPN3, LIMA1, PHLDB2, ARHGEF16, IQGAP1, ARHGAP10, SNRPE, MTOR, PIK3C2B, CDK17, WEE1, WDR61, RFC1, TP53BP2, NDE1, PCM1, MCM3, NUMA1, CDC25A, FBXO6, RASSF2, ALDH7A1, CAPN1, MAT2B, PGD, SMS, TXNDC5, UBFD1, VCL, CAPNS1, ECHS1, EEF2, EIF5, G6PD, GNAI3, LDHB, SLC9A3R1, SMEK2, TGM2, UBE2V1, ERRFI1, IRS4, STAU1, SIK3, TUBGCP3, MAPT, SGK1, PIK3C3, PIK3R2, TNFAIP3, DTL, FUS, TRIM42, FOXO1, FOXO3, CUL7, OBSL1, CCDC8, EGFR, ARAF, TNK1, CDCA7, FRMD5, FRMD6, WWC1, RPS6KB2, MCFD2, SNRPD1, EIF4B, TXNDC9, NTRK1, SOCS3, LCA5, CBX4, MTX2, MAP3K2, PRKD2, RNASEH2B, PARD6B, WDR62, CRY1, CRY2, MCM2, ESRRB, CDC37, NFATC2, CDC73, WWP2, PPM1H, PTPDC1, PTPN4, SMTNL2, SPATA13, CGN, FAM189A2, PLEKHG5, SSH1, MTNR1B, CYLD, DLD, DLST, DNM1L, PARK7, SDHA, SOAT1, SOD1, GJA1, TRIM25, G3BP1, BRCA1, PRNP | ADAM17 | DLG1, MAPK1, MAD2L1, TIMP3, FBXO6, PDIA3, TNFRSF1A, TNFRSF1B, EED, PXN, PTCH1, TGFA, CDH1, SDK2, LMAN2L, INSL5, ST8SIA4, LRRC3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YWHAQ_ADAM17 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YWHAQ_ADAM17 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | YWHAQ | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Tgene | ADAM17 | C0005758 | Bulla | 1 | CTD_human |
| Tgene | ADAM17 | C0009319 | Colitis | 1 | CTD_human |
| Tgene | ADAM17 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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