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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42412

FusionGeneSummary for YWHAH_DEPDC5

check button Fusion gene summary
Fusion gene informationFusion gene name: YWHAH_DEPDC5
Fusion gene ID: 42412
HgeneTgene
Gene symbol

YWHAH

DEPDC5

Gene ID

7533

9681

Gene nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein etaDEP domain containing 5
SynonymsYWHA1DEP.5|FFEVF|FFEVF1
Cytomap

22q12.3

22q12.2-q12.3

Type of geneprotein-codingprotein-coding
Description14-3-3 protein eta14-3-3 etatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptideGATOR complex protein DEPDC5DEP domain-containing protein 5
Modification date2018052220180523
UniProtAcc

Q04917

O75140

Ensembl transtripts involved in fusion geneENST00000248975, ENST00000397492, 
ENST00000471374, 		ENST00000535622, 
ENST00000400246, ENST00000266091, 
ENST00000382105, ENST00000400249, 
ENST00000382112, ENST00000382111, 
ENST00000400248, ENST00000494060, 
ENST00000536766, ENST00000400242, 
ENST00000539165, 
Fusion gene scores* DoF score3 X 4 X 2=247 X 7 X 5=245
# samples 47
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YWHAH [Title/Abstract] AND DEPDC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYWHAH

GO:0002028

regulation of sodium ion transport

16728661

HgeneYWHAH

GO:0006713

glucocorticoid catabolic process

15790729

HgeneYWHAH

GO:0042921

glucocorticoid receptor signaling pathway

15790729

HgeneYWHAH

GO:0045893

positive regulation of transcription, DNA-templated

15790729

HgeneYWHAH

GO:0086010

membrane depolarization during action potential

16728661

HgeneYWHAH

GO:2000649

regulation of sodium ion transmembrane transporter activity

16728661


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-23-1022-01AYWHAHchr22

32340806

+DEPDC5chr22

32297728

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000248975ENST00000535622YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000248975ENST00000400246YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000248975ENST00000266091YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-3UTRENST00000248975ENST00000382105YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-3UTRENST00000248975ENST00000400249YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-3UTRENST00000248975ENST00000382112YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000248975ENST00000382111YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000248975ENST00000400248YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000248975ENST00000494060YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000248975ENST00000536766YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000248975ENST00000400242YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000248975ENST00000539165YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
Frame-shiftENST00000397492ENST00000535622YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000397492ENST00000400246YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000397492ENST00000266091YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-3UTRENST00000397492ENST00000382105YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-3UTRENST00000397492ENST00000400249YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-3UTRENST00000397492ENST00000382112YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000397492ENST00000382111YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000397492ENST00000400248YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000397492ENST00000494060YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000397492ENST00000536766YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000397492ENST00000400242YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
5CDS-intronENST00000397492ENST00000539165YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
intron-3CDSENST00000471374ENST00000535622YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
intron-intronENST00000471374ENST00000400246YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
intron-intronENST00000471374ENST00000266091YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
intron-3UTRENST00000471374ENST00000382105YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
intron-3UTRENST00000471374ENST00000400249YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
intron-3UTRENST00000471374ENST00000382112YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
intron-intronENST00000471374ENST00000382111YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
intron-intronENST00000471374ENST00000400248YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
intron-intronENST00000471374ENST00000494060YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
intron-intronENST00000471374ENST00000536766YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
intron-intronENST00000471374ENST00000400242YWHAHchr22

32340806

+DEPDC5chr22

32297728

+
intron-intronENST00000471374ENST00000539165YWHAHchr22

32340806

+DEPDC5chr22

32297728

+

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FusionProtFeatures for YWHAH_DEPDC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YWHAH

Q04917

DEPDC5

O75140

Adapter protein implicated in the regulation of a largespectrum of both general and specialized signaling pathways. Bindsto a large number of partners, usually by recognition of aphosphoserine or phosphothreonine motif. Binding generally resultsin the modulation of the activity of the binding partner.Negatively regulates the kinase activity of PDPK1.{ECO:0000269|PubMed:12177059}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YWHAH_DEPDC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YWHAH_DEPDC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
YWHAHRIMS1, RIMS2, RPH3A, REM1, BAD, NR3C1, ZFP36, TLX2, TNFAIP3, KLC3, ARAF, SNRPE, RAF1, IRS1, PIK3CA, CDC25C, KIF5B, PRKCZ, CHRNA4, PDPK1, CDC25B, EPB41L3, CDK16, USP43, USP46, MARK2, WDR20, DMWD, HDAC7, MDM4, FOXO3, YWHAE, ING1, SAMSN1, YWHAQ, HDAC5, MARK4, PRKCI, PARD3, DCAF7, MARK3, ARHGEF2, RASSF8, DOCK7, KIF23, PARD6B, CYFIP1, PARD6G, PARD6A, MARK1, CYFIP2, TUBG1, CCDC88A, OPTN, EXO1, ELAVL1, ARRB1, ARRB2, CBL, NEDD4L, PARK2, SNCAIP, USP4, CUL3, CDK2, MEX3B, MEX3D, MEX3C, YWHAH, NEK1, LRRK2, VCP, FN1, BRAF, GRB2, TRIM32, ABL1, MST1R, MAPK7, HDAC4, FBXW4, BAG3, LATS2, MOB1A, RASSF2, SAV1, YAP1, YWHAB, HNRNPK, PAFAH1B1, PAK2, PPP1CA, UBFD1, ALDH7A1, CAPNS1, EIF5, FERMT2, G6PD, GNAI3, GSS, HMGB3, ISOC1, MYO1E, PCYT2, PDIA4, PTMA, SNRPD2, TBCB, UBE2R2, VCL, XPO1, YWHAG, YWHAZ, IRS4, SIK3, DTL, HUWE1, CCDC8, MAST1, TNK1, ABCE1, KIAA0930, CDCA7, FRMD5, FRMD6, WWC1, RPS6KB2, HSPB1, NTRK1, LCA5, CC2D2A, CEP170, CEP162, CEP290, CEP152, CEP128, CEP135, CEP89, CNTRL, NIN, RPGRIP1L, EVC2, TMEM17, CENPJ, ABCA2, CLK3, NHS, LGMN, TP53BP2, RBM7, WDR62, RAE1, IRS2, HOMER3, FXR2, NOS1AP, RUSC2, DCLRE1A, SRSF8, MYCBP2, KIF1B, SRRM2, TFB1M, PTOV1, C10orf2, ZC3H14, ERMP1, FAM192A, REEP4, EPPK1, SPRYD3, OSBPL5, FBXO45, OARD1, EML3, FRYL, NSUN4, FAM83G, CRY1, MCM2, NF1, PPM1H, PTPN3, PTPN4, TENC1, CDC25A, MTMR4, SMTNL2, CGN, PRICKLE3, SPATA13, SAMD4A, PLEKHG5, RIN1, TESPA1, PTPDC1, PTPN14, SSH1, DLD, G3BP1, BRD1DEPDC5ZNF414, NPRL2, WDR24, RRAGC, RRAGA, NPRL3, RRAGB, C7orf60, SZT2, C12orf66, ITFG2, KPTN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YWHAH_DEPDC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for YWHAH_DEPDC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneYWHAHC0005586Bipolar Disorder1PSYGENET
HgeneYWHAHC0011853Diabetes Mellitus, Experimental1CTD_human
HgeneYWHAHC0036341Schizophrenia1PSYGENET
HgeneYWHAHC0878544Cardiomyopathies1CTD_human
TgeneDEPDC5C1858477Epilepsy, Partial, with Variable Foci3CTD_human;UNIPROT
TgeneDEPDC5C2239176Liver carcinoma1CTD_human