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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42354

FusionGeneSummary for YME1L1_ZNF438

check button Fusion gene summary
Fusion gene informationFusion gene name: YME1L1_ZNF438
Fusion gene ID: 42354
HgeneTgene
Gene symbol

YME1L1

ZNF438

Gene ID

10730

220929

Gene nameYME1 like 1 ATPasezinc finger protein 438
SynonymsFTSH|MEG4|OPA11|PAMP|YME1LbA330O11.1
Cytomap

10p12.1

10p11.23

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent zinc metalloprotease YME1L1ATP-dependent metalloprotease FtsH1 homologYME1-like protein 1meg-4presenilin-associated metalloproteasezinc finger protein 438
Modification date2018052320180523
UniProtAcc

Q96TA2

Q7Z4V0

Ensembl transtripts involved in fusion geneENST00000326799, ENST00000376016, 
ENST00000375972, ENST00000463270, 
ENST00000477432, 
ENST00000331737, 
ENST00000361310, ENST00000413025, 
ENST00000436087, ENST00000452305, 
ENST00000442986, ENST00000538351, 
ENST00000375311, ENST00000444692, 
Fusion gene scores* DoF score6 X 5 X 4=1205 X 7 X 5=175
# samples 612
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/175*10)=-0.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YME1L1 [Title/Abstract] AND ZNF438 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYME1L1

GO:0034214

protein hexamerization

27786171


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1740-01AYME1L1chr10

27437835

-ZNF438chr10

31197944

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000326799ENST00000331737YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000326799ENST00000361310YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000326799ENST00000413025YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000326799ENST00000436087YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000326799ENST00000452305YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000326799ENST00000442986YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000326799ENST00000538351YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000326799ENST00000375311YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-intronENST00000326799ENST00000444692YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000376016ENST00000331737YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000376016ENST00000361310YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000376016ENST00000413025YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000376016ENST00000436087YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000376016ENST00000452305YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000376016ENST00000442986YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000376016ENST00000538351YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000376016ENST00000375311YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-intronENST00000376016ENST00000444692YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000375972ENST00000331737YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000375972ENST00000361310YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000375972ENST00000413025YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000375972ENST00000436087YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000375972ENST00000452305YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000375972ENST00000442986YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000375972ENST00000538351YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000375972ENST00000375311YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-intronENST00000375972ENST00000444692YME1L1chr10

27437835

-ZNF438chr10

31197944

-
intron-5UTRENST00000463270ENST00000331737YME1L1chr10

27437835

-ZNF438chr10

31197944

-
intron-5UTRENST00000463270ENST00000361310YME1L1chr10

27437835

-ZNF438chr10

31197944

-
intron-5UTRENST00000463270ENST00000413025YME1L1chr10

27437835

-ZNF438chr10

31197944

-
intron-5UTRENST00000463270ENST00000436087YME1L1chr10

27437835

-ZNF438chr10

31197944

-
intron-5UTRENST00000463270ENST00000452305YME1L1chr10

27437835

-ZNF438chr10

31197944

-
intron-5UTRENST00000463270ENST00000442986YME1L1chr10

27437835

-ZNF438chr10

31197944

-
intron-5UTRENST00000463270ENST00000538351YME1L1chr10

27437835

-ZNF438chr10

31197944

-
intron-5UTRENST00000463270ENST00000375311YME1L1chr10

27437835

-ZNF438chr10

31197944

-
intron-intronENST00000463270ENST00000444692YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000477432ENST00000331737YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000477432ENST00000361310YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000477432ENST00000413025YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000477432ENST00000436087YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000477432ENST00000452305YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000477432ENST00000442986YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000477432ENST00000538351YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-5UTRENST00000477432ENST00000375311YME1L1chr10

27437835

-ZNF438chr10

31197944

-
5CDS-intronENST00000477432ENST00000444692YME1L1chr10

27437835

-ZNF438chr10

31197944

-

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FusionProtFeatures for YME1L1_ZNF438


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YME1L1

Q96TA2

ZNF438

Q7Z4V0

ATP-dependent metalloprotease that catalyzes thedegradation of folded and unfolded proteins with a suitable degronsequence in the mitochondrial intermembrane region(PubMed:26923599, PubMed:27786171). Plays an important role inregulating mitochondrial morphology and function by cleaving OPA1at position S2, giving rise to a form of OPA1 that promotesmaintenance of normal mitochondrial structure and mitochondrialprotein metabolism (PubMed:18076378, PubMed:26923599,PubMed:27495975). Ensures cell proliferation, maintains normalcristae morphology and complex I respiration activity, promotesantiapoptotic activity and protects mitochondria from theaccumulation of oxidatively damaged membrane proteins(PubMed:22262461). Required for normal, constitutive degradationof PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 inresponse to membrane depolarization (PubMed:26923599). Required tocontrol the accumulation of nonassembled respiratory chainsubunits (NDUFB6, OX4 and ND1) (PubMed:22262461).{ECO:0000269|PubMed:18076378, ECO:0000269|PubMed:22262461,ECO:0000269|PubMed:26923599, ECO:0000269|PubMed:27495975,ECO:0000269|PubMed:27786171}. Isoform 1 acts as a transcriptional repressor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YME1L1_ZNF438


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YME1L1_ZNF438


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
YME1L1PSEN1, ICT1, FKBP8, DAP3, VDAC3, SSBP1, COX2, NDUFB6, ND5, ND2, ND6, MYOG, BCL11A, DYRK4, HIPK4, PHKG2, UNK, ATP5A1, ATP5F1, CAD, NTRK1, PTEN, NDUFA11, NDUFA13, TIMMDC1, TBC1D9, AP4E1, TMEM63B, GEMIN7, ENTHD2, CHCHD10, APOOL, OPA3, OCIAD1, PDP2, TTC25, INTUZNF438


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YME1L1_ZNF438


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for YME1L1_ZNF438


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZNF438C0025202melanoma1CTD_human