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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42351

FusionGeneSummary for YME1L1_BRD8

check button Fusion gene summary
Fusion gene informationFusion gene name: YME1L1_BRD8
Fusion gene ID: 42351
HgeneTgene
Gene symbol

YME1L1

BRD8

Gene ID

10730

10902

Gene nameYME1 like 1 ATPasebromodomain containing 8
SynonymsFTSH|MEG4|OPA11|PAMP|YME1LSMAP|SMAP2|p120
Cytomap

10p12.1

5q31.2

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent zinc metalloprotease YME1L1ATP-dependent metalloprotease FtsH1 homologYME1-like protein 1meg-4presenilin-associated metalloproteasebromodomain-containing protein 8skeletal muscle abundant protein 2thyroid hormone receptor coactivating protein of 120 kDatrCP120
Modification date2018052320180519
UniProtAcc

Q96TA2

Q9H0E9

Ensembl transtripts involved in fusion geneENST00000326799, ENST00000376016, 
ENST00000375972, ENST00000463270, 
ENST00000477432, 		ENST00000254900, 
ENST00000230901, ENST00000402931, 
ENST00000411594, ENST00000455658, 
ENST00000515014, 
Fusion gene scores* DoF score6 X 5 X 4=1203 X 3 X 3=27
# samples 63
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: YME1L1 [Title/Abstract] AND BRD8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYME1L1

GO:0034214

protein hexamerization

27786171

TgeneBRD8

GO:0043967

histone H4 acetylation

14966270

TgeneBRD8

GO:0043968

histone H2A acetylation

14966270


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE939651YME1L1chr10

27405194

+BRD8chr5

137502410

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000326799ENST00000254900YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000326799ENST00000230901YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000326799ENST00000402931YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000326799ENST00000411594YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000326799ENST00000455658YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000326799ENST00000515014YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000376016ENST00000254900YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000376016ENST00000230901YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000376016ENST00000402931YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000376016ENST00000411594YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000376016ENST00000455658YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000376016ENST00000515014YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000375972ENST00000254900YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000375972ENST00000230901YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000375972ENST00000402931YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000375972ENST00000411594YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000375972ENST00000455658YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000375972ENST00000515014YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000463270ENST00000254900YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000463270ENST00000230901YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000463270ENST00000402931YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000463270ENST00000411594YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000463270ENST00000455658YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000463270ENST00000515014YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000477432ENST00000254900YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000477432ENST00000230901YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-3CDSENST00000477432ENST00000402931YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000477432ENST00000411594YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000477432ENST00000455658YME1L1chr10

27405194

+BRD8chr5

137502410

-
intron-intronENST00000477432ENST00000515014YME1L1chr10

27405194

+BRD8chr5

137502410

-

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FusionProtFeatures for YME1L1_BRD8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YME1L1

Q96TA2

BRD8

Q9H0E9

ATP-dependent metalloprotease that catalyzes thedegradation of folded and unfolded proteins with a suitable degronsequence in the mitochondrial intermembrane region(PubMed:26923599, PubMed:27786171). Plays an important role inregulating mitochondrial morphology and function by cleaving OPA1at position S2, giving rise to a form of OPA1 that promotesmaintenance of normal mitochondrial structure and mitochondrialprotein metabolism (PubMed:18076378, PubMed:26923599,PubMed:27495975). Ensures cell proliferation, maintains normalcristae morphology and complex I respiration activity, promotesantiapoptotic activity and protects mitochondria from theaccumulation of oxidatively damaged membrane proteins(PubMed:22262461). Required for normal, constitutive degradationof PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 inresponse to membrane depolarization (PubMed:26923599). Required tocontrol the accumulation of nonassembled respiratory chainsubunits (NDUFB6, OX4 and ND1) (PubMed:22262461).{ECO:0000269|PubMed:18076378, ECO:0000269|PubMed:22262461,ECO:0000269|PubMed:26923599, ECO:0000269|PubMed:27495975,ECO:0000269|PubMed:27786171}. May act as a coactivator during transcriptionalactivation by hormone-activated nuclear receptors (NR). Isoform 2stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1,RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 arecomponents of the NuA4 histone acetyltransferase (HAT) complexwhich is involved in transcriptional activation of select genesprincipally by acetylation of nucleosomal histones H4 and H2A.This modification may both alter nucleosome - DNA interactions andpromote interaction of the modified histones with other proteinswhich positively regulate transcription. This complex may berequired for the activation of transcriptional programs associatedwith oncogene and proto-oncogene mediated growth induction, tumorsuppressor mediated growth arrest and replicative senescence,apoptosis, and DNA repair. NuA4 may also play a direct role in DNArepair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histoneH2A.Z/H2AFZ from the nucleosome. {ECO:0000269|PubMed:10517671,ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YME1L1_BRD8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YME1L1_BRD8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YME1L1_BRD8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for YME1L1_BRD8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBRD8C0014175Endometriosis1CTD_human