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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42343

FusionGeneSummary for YKT6_EIF3B

check button Fusion gene summary
Fusion gene informationFusion gene name: YKT6_EIF3B
Fusion gene ID: 42343
HgeneTgene
Gene symbol

YKT6

EIF3B

Gene ID

10652

8662

Gene nameYKT6 v-SNARE homologeukaryotic translation initiation factor 3 subunit B
Synonyms-EIF3-ETA|EIF3-P110|EIF3-P116|EIF3S9|PRT1
Cytomap

7p13

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionsynaptobrevin homolog YKT6R-SNARESNARE protein Ykt6YKT6 v-SNARE proteinYKT6, S. cerevisiae, homolog ofeukaryotic translation initiation factor 3 subunit Beukaryotic translation initiation factor 3 subunit 9eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD)eukaryotic translation initiation factor 3, subunit 9 eta, 116kDaprt1 homolog
Modification date2018052620180523
UniProtAcc

O15498

P55884

Ensembl transtripts involved in fusion geneENST00000496112, ENST00000447123, 
ENST00000223369, 
ENST00000360876, 
ENST00000397011, 
Fusion gene scores* DoF score2 X 3 X 2=129 X 11 X 5=495
# samples 311
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/495*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YKT6 [Title/Abstract] AND EIF3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYKT6

GO:0006888

ER to Golgi vesicle-mediated transport

9211930

HgeneYKT6

GO:0006903

vesicle targeting

9211930

HgeneYKT6

GO:0006904

vesicle docking involved in exocytosis

9211930

HgeneYKT6

GO:0042147

retrograde transport, endosome to Golgi

15215310

TgeneEIF3B

GO:0006413

translational initiation

8995410|17581632

TgeneEIF3B

GO:0006446

regulation of translational initiation

8995410

TgeneEIF3B

GO:0075522

IRES-dependent viral translational initiation

9573242

TgeneEIF3B

GO:0075525

viral translational termination-reinitiation

21347434


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-SG-A849-01AYKT6chr7

44240838

+EIF3Bchr7

2419029

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000496112ENST00000360876YKT6chr7

44240838

+EIF3Bchr7

2419029

+
Frame-shiftENST00000496112ENST00000397011YKT6chr7

44240838

+EIF3Bchr7

2419029

+
3UTR-3CDSENST00000447123ENST00000360876YKT6chr7

44240838

+EIF3Bchr7

2419029

+
3UTR-3CDSENST00000447123ENST00000397011YKT6chr7

44240838

+EIF3Bchr7

2419029

+
Frame-shiftENST00000223369ENST00000360876YKT6chr7

44240838

+EIF3Bchr7

2419029

+
Frame-shiftENST00000223369ENST00000397011YKT6chr7

44240838

+EIF3Bchr7

2419029

+

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FusionProtFeatures for YKT6_EIF3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YKT6

O15498

EIF3B

P55884

Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptorcellular compartment. Functions in endoplasmic reticulum to Golgitransport; as part of a SNARE complex composed of GOSR1, GOSR2 andSTX5. Functions in early/recycling endosome to TGN transport; aspart of a SNARE complex composed of BET1L, GOSR1 and STX5. Has aS-palmitoyl transferase activity. {ECO:0000269|PubMed:15215310,ECO:0000269|PubMed:9211930}. RNA-binding component of the eukaryotic translationinitiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis (PubMed:9388245,PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5to form the 43S pre-initiation complex (43S PIC). The eIF-3complex stimulates mRNA recruitment to the 43S PIC and scanning ofthe mRNA for AUG recognition. The eIF-3 complex is also requiredfor disassembly and recycling of post-termination ribosomalcomplexes and subsequently prevents premature joining of the 40Sand 60S ribosomal subunits prior to initiation (PubMed:9388245,PubMed:17581632). The eIF-3 complex specifically targets andinitiates translation of a subset of mRNAs involved in cellproliferation, including cell cycling, differentiation andapoptosis, and uses different modes of RNA stem-loop binding toexert either translational activation or repression(PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001,ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773,ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}. (Microbial infection) In case of FCV infection, plays arole in the ribosomal termination-reinitiation event leading tothe translation of VP2 (PubMed:18056426).{ECO:0000269|PubMed:18056426}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YKT6_EIF3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YKT6_EIF3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
YKT6USO1, GOSR1, BET1L, STX5, HNRNPH1, MPST, LMNA, BAG3, HSPA9, ARL6IP6, STX7, STX12, STX3, TAS2R41, RABGGTB, FNTB, CHRNA9, CNN3, CRIP1, CRYZ, DBI, ETFA, FKBP1A, GOT1, MDH2, MEMO1, MIF, PEBP1, RFK, TAGLN, TAGLN2, TAGLN3, TKT, UBE2V1, TMEM189-UBE2V1, UFC1, C11orf54, PCMT1, SPR, TCTN2, TCTN3, TMEM17, TMEM216, CDH1, PTAR1, AARSD1, C1QL1, STX11, RABGGTAEIF3BEIF3A, EIF4A1, EIF4B, EIF4E, EIF4G1, MTOR, RPS6, RPS6KB1, EIF6, EIF3C, EIF3I, EIF3J, RPTOR, EIF3G, EIF3H, EIF3F, USP3, SRRM2, TADA2A, CD4, HDAC5, EIF3E, EIF3K, EIF3L, EIF3M, RAD21, EIF3D, EIF5, RPLP0P6, BRCA1, SMURF1, DDX3X, FN1, VCAM1, UPF1, ITGA4, PAN2, CD81, IGSF8, ICAM1, FBXO6, TARDBP, DYNC1I2, MCM4, CSNK2A2, RIOK2, STAU1, NCBP1, MDM2, CCDC8, EED, RNF2, RSPH9, RPS6KB2, PAIP1, ATL3, ATP6V0D1, ATP1A1, EIF3CL, MRPL40, MSH2, VAPA, NTRK1, EIF4G3, HERC2, AHSA1, MYO1C, GAN, MCM2, CDC37, ZNF746, EGFR, CYLD, DLD, DNM1L, PARK7, G3BP1, CCND2, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YKT6_EIF3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for YKT6_EIF3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEIF3BC0019693HIV Infections1CTD_human