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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42330

FusionGeneSummary for YES1_SETD3

check button Fusion gene summary
Fusion gene informationFusion gene name: YES1_SETD3
Fusion gene ID: 42330
HgeneTgene
Gene symbol

YES1

SETD3

Gene ID

7525

84193

Gene nameYES proto-oncogene 1, Src family tyrosine kinaseSET domain containing 3
SynonymsHsT441|P61-YES|Yes|c-yesC14orf154
Cytomap

18p11.32

14q32.2

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase YesYES1 proto-oncogene, Src family tyrosine kinaseYamaguchi sarcoma oncogenecellular yes-1 proteinproto-oncogene c-Yesproto-oncogene tyrosine-protein kinase YESv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1histone-lysine N-methyltransferase setd3SET domain-containing protein 3
Modification date2018052320180523
UniProtAcc

P07947

Q86TU7

Ensembl transtripts involved in fusion geneENST00000584307, ENST00000314574, 
ENST00000577611, ENST00000577961, 
ENST00000331768, ENST00000329331, 
ENST00000436070, ENST00000453938, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 4 X 2=32
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/32*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: YES1 [Title/Abstract] AND SETD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI810066YES1chr18

721932

+SETD3chr14

99892308

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000584307ENST00000331768YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000584307ENST00000329331YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000584307ENST00000436070YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000584307ENST00000453938YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000314574ENST00000331768YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000314574ENST00000329331YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000314574ENST00000436070YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000314574ENST00000453938YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000577611ENST00000331768YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000577611ENST00000329331YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000577611ENST00000436070YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000577611ENST00000453938YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000577961ENST00000331768YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000577961ENST00000329331YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000577961ENST00000436070YES1chr18

721932

+SETD3chr14

99892308

+
intron-intronENST00000577961ENST00000453938YES1chr18

721932

+SETD3chr14

99892308

+

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FusionProtFeatures for YES1_SETD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YES1

P07947

SETD3

Q86TU7

Non-receptor protein tyrosine kinase that is involved inthe regulation of cell growth and survival, apoptosis, cell-celladhesion, cytoskeleton remodeling, and differentiation.Stimulation by receptor tyrosine kinases (RTKs) including EGRF,PDGFR, CSF1R and FGFR leads to recruitment of YES1 to thephosphorylated receptor, and activation and phosphorylation ofdownstream substrates. Upon EGFR activation, promotes thephosphorylation of PARD3 to favor epithelial tight junctionassembly. Participates in the phosphorylation of specificjunctional components such as CTNND1 by stimulating the FYN andFER tyrosine kinases at cell-cell contacts. Upon T-cellstimulation by CXCL12, phosphorylates collapsin response mediatorprotein 2/DPYSL2 and induces T-cell migration. Participates inCD95L/FASLG signaling pathway and mediates AKT-mediated cellmigration. Plays a role in cell cycle progression byphosphorylating the cyclin-dependent kinase 4/CDK4 thus regulatingthe G1 phase. Also involved in G2/M progression and cytokinesis.{ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465,ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460,ECO:0000269|PubMed:21713032}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YES1_SETD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YES1_SETD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YES1_SETD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneYES1P07947DB01254DasatinibTyrosine-protein kinase Yessmall moleculeapproved|investigational

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RelatedDiseases for YES1_SETD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneYES1C0013069Double Outlet Right Ventricle1CTD_human
HgeneYES1C0018818Ventricular Septal Defects1CTD_human
HgeneYES1C0158570Vascular anomaly1CTD_human