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Fusion gene ID: 42327 |
FusionGeneSummary for YES1_DAGLB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: YES1_DAGLB | Fusion gene ID: 42327 | Hgene | Tgene | Gene symbol | YES1 | DAGLB | Gene ID | 7525 | 221955 |
| Gene name | YES proto-oncogene 1, Src family tyrosine kinase | diacylglycerol lipase beta | |
| Synonyms | HsT441|P61-YES|Yes|c-yes | DAGLBETA|KCCR13L | |
| Cytomap | 18p11.32 | 7p22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein kinase YesYES1 proto-oncogene, Src family tyrosine kinaseYamaguchi sarcoma oncogenecellular yes-1 proteinproto-oncogene c-Yesproto-oncogene tyrosine-protein kinase YESv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | sn1-specific diacylglycerol lipase betaDGL-beta | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P07947 | Q8NCG7 | |
| Ensembl transtripts involved in fusion gene | ENST00000584307, ENST00000314574, ENST00000577611, ENST00000577961, | ENST00000297056, ENST00000425398, ENST00000436575, ENST00000428902, ENST00000421761, ENST00000479922, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 5 X 5 X 1=25 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/25*10)=1.48542682717024 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: YES1 [Title/Abstract] AND DAGLB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DAGLB | GO:0019369 | arachidonic acid metabolic process | 14610053 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE927703 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000584307 | ENST00000297056 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000584307 | ENST00000425398 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000584307 | ENST00000436575 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000584307 | ENST00000428902 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000584307 | ENST00000421761 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000584307 | ENST00000479922 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000314574 | ENST00000297056 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000314574 | ENST00000425398 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000314574 | ENST00000436575 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000314574 | ENST00000428902 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000314574 | ENST00000421761 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000314574 | ENST00000479922 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000577611 | ENST00000297056 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000577611 | ENST00000425398 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000577611 | ENST00000436575 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000577611 | ENST00000428902 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000577611 | ENST00000421761 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000577611 | ENST00000479922 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000577961 | ENST00000297056 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000577961 | ENST00000425398 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000577961 | ENST00000436575 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000577961 | ENST00000428902 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000577961 | ENST00000421761 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
| intron-intron | ENST00000577961 | ENST00000479922 | YES1 | chr18 | 722376 | - | DAGLB | chr7 | 6501879 | - |
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FusionProtFeatures for YES1_DAGLB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| YES1 | DAGLB |
| Non-receptor protein tyrosine kinase that is involved inthe regulation of cell growth and survival, apoptosis, cell-celladhesion, cytoskeleton remodeling, and differentiation.Stimulation by receptor tyrosine kinases (RTKs) including EGRF,PDGFR, CSF1R and FGFR leads to recruitment of YES1 to thephosphorylated receptor, and activation and phosphorylation ofdownstream substrates. Upon EGFR activation, promotes thephosphorylation of PARD3 to favor epithelial tight junctionassembly. Participates in the phosphorylation of specificjunctional components such as CTNND1 by stimulating the FYN andFER tyrosine kinases at cell-cell contacts. Upon T-cellstimulation by CXCL12, phosphorylates collapsin response mediatorprotein 2/DPYSL2 and induces T-cell migration. Participates inCD95L/FASLG signaling pathway and mediates AKT-mediated cellmigration. Plays a role in cell cycle progression byphosphorylating the cyclin-dependent kinase 4/CDK4 thus regulatingthe G1 phase. Also involved in G2/M progression and cytokinesis.{ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465,ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460,ECO:0000269|PubMed:21713032}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for YES1_DAGLB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for YES1_DAGLB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YES1_DAGLB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | YES1 | P07947 | DB01254 | Dasatinib | Tyrosine-protein kinase Yes | small molecule | approved|investigational |
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RelatedDiseases for YES1_DAGLB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | YES1 | C0013069 | Double Outlet Right Ventricle | 1 | CTD_human |
| Hgene | YES1 | C0018818 | Ventricular Septal Defects | 1 | CTD_human |
| Hgene | YES1 | C0158570 | Vascular anomaly | 1 | CTD_human |
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