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Fusion gene ID: 42311 |
FusionGeneSummary for YEATS2_SIN3B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: YEATS2_SIN3B | Fusion gene ID: 42311 | Hgene | Tgene | Gene symbol | YEATS2 | SIN3B | Gene ID | 55689 | 23309 |
| Gene name | YEATS domain containing 2 | SIN3 transcription regulator family member B | |
| Synonyms | - | - | |
| Cytomap | 3q27.1 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | YEATS domain-containing protein 2 | paired amphipathic helix protein Sin3bSIN3 homolog B, transcriptional regulatorSIN3 transcription regulator homolog Bhistone deacetylase complex subunit Sin3btranscriptional corepressor Sin3b | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9ULM3 | O75182 | |
| Ensembl transtripts involved in fusion gene | ENST00000305135, | ENST00000248054, ENST00000596802, ENST00000379803, ENST00000595541, ENST00000594235, | |
| Fusion gene scores | * DoF score | 11 X 7 X 6=462 | 2 X 3 X 1=6 |
| # samples | 11 | 3 | |
| ** MAII score | log2(11/462*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/6*10)=2.32192809488736 | |
| Context | PubMed: YEATS2 [Title/Abstract] AND SIN3B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | YEATS2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 18838386 |
| Hgene | YEATS2 | GO:0043966 | histone H3 acetylation | 18838386 |
| Hgene | YEATS2 | GO:0045892 | negative regulation of transcription, DNA-templated | 18838386 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ181363 | YEATS2 | chr3 | 183529995 | - | SIN3B | chr19 | 16954702 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000305135 | ENST00000248054 | YEATS2 | chr3 | 183529995 | - | SIN3B | chr19 | 16954702 | - |
| 3UTR-intron | ENST00000305135 | ENST00000596802 | YEATS2 | chr3 | 183529995 | - | SIN3B | chr19 | 16954702 | - |
| 3UTR-intron | ENST00000305135 | ENST00000379803 | YEATS2 | chr3 | 183529995 | - | SIN3B | chr19 | 16954702 | - |
| 3UTR-intron | ENST00000305135 | ENST00000595541 | YEATS2 | chr3 | 183529995 | - | SIN3B | chr19 | 16954702 | - |
| 3UTR-intron | ENST00000305135 | ENST00000594235 | YEATS2 | chr3 | 183529995 | - | SIN3B | chr19 | 16954702 | - |
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FusionProtFeatures for YEATS2_SIN3B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| YEATS2 | SIN3B |
| Chromatin reader component of the ATAC complex, acomplex with histone acetyltransferase activity on histones H3 andH4. YEATS2 specifically recognizes and binds histone H3crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431).Crotonylation marks active promoters and enhancers and confersresistance to transcriptional repressors (PubMed:27103431).{ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755,ECO:0000269|PubMed:27103431}. | Acts as a transcriptional repressor. Interacts with MXI1to repress MYC responsive genes and antagonize MYC oncogenicactivities. Interacts with MAD-MAX heterodimers by binding to MAD.The heterodimer then represses transcription by tethering SIN3B toDNA. Also forms a complex with FOXK1 which repressestranscription. With FOXK1, regulates cell cycle progressionprobably by repressing cell cycle inhibitor genes expression.{ECO:0000250|UniProtKB:Q62141}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for YEATS2_SIN3B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for YEATS2_SIN3B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YEATS2_SIN3B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YEATS2_SIN3B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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