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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42310

FusionGeneSummary for YEATS2_PRKCI

check button Fusion gene summary
Fusion gene informationFusion gene name: YEATS2_PRKCI
Fusion gene ID: 42310
HgeneTgene
Gene symbol

YEATS2

PRKCI

Gene ID

55689

5584

Gene nameYEATS domain containing 2protein kinase C iota
Synonyms-DXS1179E|PKCI|nPKC-iota
Cytomap

3q27.1

3q26.2

Type of geneprotein-codingprotein-coding
DescriptionYEATS domain-containing protein 2protein kinase C iota typePRKC-lambda/iotaaPKC-lambda/iotaatypical protein kinase C-lambda/iota
Modification date2018051920180523
UniProtAcc

Q9ULM3

P41743

Ensembl transtripts involved in fusion geneENST00000305135, ENST00000295797, 
Fusion gene scores* DoF score11 X 7 X 6=4626 X 6 X 6=216
# samples 116
** MAII scorelog2(11/462*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/216*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YEATS2 [Title/Abstract] AND PRKCI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYEATS2

GO:0000122

negative regulation of transcription by RNA polymerase II

18838386

HgeneYEATS2

GO:0043966

histone H3 acetylation

18838386

HgeneYEATS2

GO:0045892

negative regulation of transcription, DNA-templated

18838386

TgenePRKCI

GO:0006468

protein phosphorylation

8226978

TgenePRKCI

GO:0018105

peptidyl-serine phosphorylation

21983565

TgenePRKCI

GO:0043524

negative regulation of neuron apoptotic process

10467349

TgenePRKCI

GO:0051092

positive regulation of NF-kappaB transcription factor activity

10467349


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRPTCGA-G7-6793-01AYEATS2chr3

183415781

+PRKCIchr3

169953018

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000305135ENST00000295797YEATS2chr3

183415781

+PRKCIchr3

169953018

+

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FusionProtFeatures for YEATS2_PRKCI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YEATS2

Q9ULM3

PRKCI

P41743

Chromatin reader component of the ATAC complex, acomplex with histone acetyltransferase activity on histones H3 andH4. YEATS2 specifically recognizes and binds histone H3crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431).Crotonylation marks active promoters and enhancers and confersresistance to transcriptional repressors (PubMed:27103431).{ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755,ECO:0000269|PubMed:27103431}. Calcium- and diacylglycerol-independent serine/threonine-protein kinase that plays a general protective roleagainst apoptotic stimuli, is involved in NF-kappa-B activation,cell survival, differentiation and polarity, and contributes tothe regulation of microtubule dynamics in the early secretorypathway. Is necessary for BCR-ABL oncogene-mediated resistance toapoptotic drug in leukemia cells, protecting leukemia cellsagainst drug-induced apoptosis. In cultured neurons, preventsamyloid beta protein-induced apoptosis by interrupting cell deathprocess at a very early step. In glioblastoma cells, may functiondownstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 inthe promotion of cell survival by phosphorylating and inhibitingthe pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 andregulate ECT2 oncogenic activity by phosphorylation, which in turnpromotes transformed growth and invasion. In response to nervegrowth factor (NGF), acts downstream of SRC to phosphorylate andactivate IRAK1, allowing the subsequent activation of NF-kappa-Band neuronal cell survival. Functions in the organization of theapical domain in epithelial cells by phosphorylating EZR. Thisstep is crucial for activation and normal distribution of EZR atthe early stages of intestinal epithelial cell differentiation.Forms a protein complex with LLGL1 and PARD6B independently ofPARD3 to regulate epithelial cell polarity. Plays a role inmicrotubule dynamics in the early secretory pathway throughinteraction with RAB2A and GAPDH and recruitment to vesiculartubular clusters (VTCs). In human coronary artery endothelialcells (HCAEC), is activated by saturated fatty acids and mediateslipid-induced apoptosis. {ECO:0000269|PubMed:10356400,ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326,ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794,ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752,ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268,ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248,ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978,ECO:0000269|PubMed:9346882}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YEATS2_PRKCI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YEATS2_PRKCI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
YEATS2RAD21, TFAP4, ZZZ3, UBAP2L, CSRP2BP, KAT2A, KAT2B, MAP3K7, TADA3, TADA2A, MBIP, WDR5, CCDC101, DR1, POLE3, POLE4, SNRNP200, NXF1, MAGEA10, PSME3, RFPL4B, BCAT1, TSSC1, CARD8, PSMC3, TBP, CEP162, CEP120, CDK2, CDC23, NANOG, POU5F1, IKZF5, SPERT, CDH19, LMO2, CCBL1, TP53INP1, IL17RA, TRIM25, TXNIPPRKCIPDPK1, PARD6A, BAD, ADAP1, YWHAZ, RAB4A, SQSTM1, SMG1, GAPDH, PARD3, FRS2, USP21, MARK2, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, SFPQ, VHL, CHUK, IKBKB, DUSP1, YWHAH, MARK4, PARD6B, PARD6G, GBAS, LLGL1, HSP90AA1, LLGL2, CDC37, NIPSNAP1, RAPGEF2, MYO10, PNMA1, FABP4, TTR, TSC22D1, MBP, CDK7, ELAVL1, TJP1, ARHGAP17, MAP2K5, APP, YWHAE, GAB1, NPM1, CRX, CASP8, IL1RAP, IKBKG, AMOT, PRKCZ, RHOJ, RASSF8, KIF23, PPM1A, PPM1B, CEP135, TMEM17, XPO1, SSB, MAGED2, ZNF609, TMEM208, EIF4ENIF1, TRAPPC13, MASTL, SMURF1, MTMR4, FYN, NGEF, KBTBD7, GPR156, FARP2, CD44, FGB, ARHGEF16, KERA, PDGFD, UBC, DCAF7, TRIM25, WWC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YEATS2_PRKCI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for YEATS2_PRKCI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRKCIC0005586Bipolar Disorder2PSYGENET
TgenePRKCIC0011570Mental Depression1PSYGENET
TgenePRKCIC0011581Depressive disorder1PSYGENET