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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42308

FusionGeneSummary for YEATS2_LIPH

check button Fusion gene summary
Fusion gene informationFusion gene name: YEATS2_LIPH
Fusion gene ID: 42308
HgeneTgene
Gene symbol

YEATS2

LIPH

Gene ID

55689

200879

Gene nameYEATS domain containing 2lipase H
Synonyms-AH|ARWH2|HYPT7|LAH2|LPDLR|PLA1B|mPA-PLA1
Cytomap

3q27.1

3q27.2

Type of geneprotein-codingprotein-coding
DescriptionYEATS domain-containing protein 2lipase member HLPD lipase-related proteinlipase, member HmPA-PLA1 alphamembrane-associated phosphatidic acid-selective phospholipase A1-alphamembrane-bound phosphatidic acid-selective phospholipase A1phospholipase A(1)phospholipase A1 member B
Modification date2018051920180519
UniProtAcc

Q9ULM3

Q8WWY8

Ensembl transtripts involved in fusion geneENST00000305135, ENST00000296252, 
ENST00000424591, 
Fusion gene scores* DoF score11 X 7 X 6=4626 X 6 X 5=180
# samples 116
** MAII scorelog2(11/462*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YEATS2 [Title/Abstract] AND LIPH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYEATS2

GO:0000122

negative regulation of transcription by RNA polymerase II

18838386

HgeneYEATS2

GO:0043966

histone H3 acetylation

18838386

HgeneYEATS2

GO:0045892

negative regulation of transcription, DNA-templated

18838386

TgeneLIPH

GO:0016042

lipid catabolic process

12963729


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-21-1071-01AYEATS2chr3

183415781

+LIPHchr3

185252920

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000305135ENST00000296252YEATS2chr3

183415781

+LIPHchr3

185252920

-
5UTR-3CDSENST00000305135ENST00000424591YEATS2chr3

183415781

+LIPHchr3

185252920

-

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FusionProtFeatures for YEATS2_LIPH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YEATS2

Q9ULM3

LIPH

Q8WWY8

Chromatin reader component of the ATAC complex, acomplex with histone acetyltransferase activity on histones H3 andH4. YEATS2 specifically recognizes and binds histone H3crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431).Crotonylation marks active promoters and enhancers and confersresistance to transcriptional repressors (PubMed:27103431).{ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755,ECO:0000269|PubMed:27103431}. Hydrolyzes specifically phosphatidic acid (PA) toproduce 2-acyl lysophosphatidic acid (LPA; a potent bioactivelipid mediator) and fatty acid. Does not hydrolyze otherphospholipids, like phosphatidylserine (PS), phosphatidylcholine(PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).{ECO:0000269|PubMed:12063250, ECO:0000269|PubMed:12963729}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YEATS2_LIPH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YEATS2_LIPH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
YEATS2RAD21, TFAP4, ZZZ3, UBAP2L, CSRP2BP, KAT2A, KAT2B, MAP3K7, TADA3, TADA2A, MBIP, WDR5, CCDC101, DR1, POLE3, POLE4, SNRNP200, NXF1, MAGEA10, PSME3, RFPL4B, BCAT1, TSSC1, CARD8, PSMC3, TBP, CEP162, CEP120, CDK2, CDC23, NANOG, POU5F1, IKZF5, SPERT, CDH19, LMO2, CCBL1, TP53INP1, IL17RA, TRIM25, TXNIPLIPHMSTO1, FAT1, DYRK1A, DHX32, PTER, FLT4, RTEL1, P3H4, DNAJC12, BRIP1, NAA10, TUBA1A, ZNHIT6, NAGLU, CAMK2B, TARSL2, FREM2, ANAPC1, ECD, CDC42SE2, LRRC41, FRAS1, MANBA, ACACA, ALDH3A1, PRIM1, LRP5, CLN5, GDF11, ZNF318, FUT11, DDX11L8, HDAC3, CERCAM, COL18A1, DHFRL1, NUDCD1, DPYSL4, FPGS, HAUS7, CEP164, PHLDB3, MAP1S, TRMT1, C3orf52, EGFL7, B4GALT5, MKS1, ADAMTS2, TUBA4A, TAZ, POLA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YEATS2_LIPH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for YEATS2_LIPH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLIPHC0020678Hypotrichosis1CTD_human
TgeneLIPHC0345427Woolly hair, congenital1CTD_human;ORPHANET
TgeneLIPHC1836672Total Hypotrichosis, Mari type1UNIPROT