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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42286

FusionGeneSummary for YARS_IMPA2

check button Fusion gene summary
Fusion gene informationFusion gene name: YARS_IMPA2
Fusion gene ID: 42286
HgeneTgene
Gene symbol

YARS

IMPA2

Gene ID

8565

3613

Gene nametyrosyl-tRNA synthetaseinositol monophosphatase 2
SynonymsCMTDIC|TYRRS|YRS|YTS-
Cytomap

1p35.1

18p11.21

Type of geneprotein-codingprotein-coding
Descriptiontyrosine--tRNA ligase, cytoplasmictyrosine tRNA ligase 1, cytoplasmictyrosyl--tRNA ligasetyrosyl-tRNA synthetase, cytoplasmicinositol monophosphatase 2IMP 2IMPase 2inosine monophosphatase 2inositol monophosphatase 2 variant 1inositol monophosphatase 2 variant 2inositol(myo)-1(or 4)-monophosphatase 2myo-inositol monophosphatase 2myo-inositol monophosphatase A2
Modification date2018052320180523
UniProtAcc

P54577

O14732

Ensembl transtripts involved in fusion geneENST00000469100, ENST00000373477, 
ENST00000588752, ENST00000589238, 
ENST00000269159, ENST00000588927, 
Fusion gene scores* DoF score7 X 8 X 7=3926 X 5 X 5=150
# samples 106
** MAII scorelog2(10/392*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YARS [Title/Abstract] AND IMPA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIMPA2

GO:0046855

inositol phosphate dephosphorylation

17068342


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-A73G-01AYARSchr1

33251963

-IMPA2chr18

12009882

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000469100ENST00000588752YARSchr1

33251963

-IMPA2chr18

12009882

+
intron-5UTRENST00000469100ENST00000589238YARSchr1

33251963

-IMPA2chr18

12009882

+
intron-5UTRENST00000469100ENST00000269159YARSchr1

33251963

-IMPA2chr18

12009882

+
intron-5UTRENST00000469100ENST00000588927YARSchr1

33251963

-IMPA2chr18

12009882

+
5CDS-3UTRENST00000373477ENST00000588752YARSchr1

33251963

-IMPA2chr18

12009882

+
5CDS-5UTRENST00000373477ENST00000589238YARSchr1

33251963

-IMPA2chr18

12009882

+
5CDS-5UTRENST00000373477ENST00000269159YARSchr1

33251963

-IMPA2chr18

12009882

+
5CDS-5UTRENST00000373477ENST00000588927YARSchr1

33251963

-IMPA2chr18

12009882

+

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FusionProtFeatures for YARS_IMPA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YARS

P54577

IMPA2

O14732

Catalyzes the attachment of tyrosine to tRNA(Tyr) in atwo-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).{ECO:0000250}. Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacologicaltarget for lithium Li(+) action in brain.{ECO:0000269|PubMed:17068342}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YARS_IMPA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YARS_IMPA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
YARSARF6, SAP18, EIF1B, EIF6, CDK2, DYNC1H1, METTL16, XRCC5, FN1, VCAM1, ITGA4, NRD1, SARNP, HSPA8, ENO1, SHMT2, MOV10, NXF1, EGFR, ESR1, DDB1, G3BP2, HNRNPH2, NAA10, NAA15, PROSC, TATDN1, ACTB, ACTG1, AHNAK, CLUH, CPOX, EEF1A1, SNRPA, WDR48, YARS2, NTRK1, PPP2R2A, SORT1, FOXB1, FOXH1, FOXI2, FOXL1, FOXL2, FOXQ1, MCM2, TRIM5, GTF2E2, DLD, G3BP1IMPA2TNFRSF14, IMPA1, IMPA2, UBA3, SPACA1, A4GNT, HSF2, ALDOA, ALDOC, ARHGDIA, DUT, FSCN1, GPX4, ADSS, CARHSP1, CYCS, GLO1, HSPE1, NUDT9, PAICS, PARK7, PGLS, PLIN3, RPE, STMN1, TXN, ITPA, MSN, PABPC4, PDCD6, RDX, SCPEP1, NPPA, RBFOX1, ZIC1, AAR2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YARS_IMPA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIMPA2O14732DB01356LithiumInositol monophosphatase 2small moleculeapproved

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RelatedDiseases for YARS_IMPA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneYARSC1842237Charcot-Marie-Tooth Disease, Dominant Intermediate C1CTD_human;ORPHANET;UNIPROT
TgeneIMPA2C0005586Bipolar Disorder5PSYGENET
TgeneIMPA2C0525045Mood Disorders2PSYGENET
TgeneIMPA2C0009952Febrile Convulsions1CTD_human
TgeneIMPA2C0011570Mental Depression1PSYGENET
TgeneIMPA2C0011581Depressive disorder1PSYGENET
TgeneIMPA2C0014175Endometriosis1CTD_human
TgeneIMPA2C0036341Schizophrenia1PSYGENET