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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42283

FusionGeneSummary for YAP1_USP2

check button Fusion gene summary
Fusion gene informationFusion gene name: YAP1_USP2
Fusion gene ID: 42283
HgeneTgene
Gene symbol

YAP1

USP2

Gene ID

10413

9099

Gene nameYes associated protein 1ubiquitin specific peptidase 2
SynonymsCOB1|YAP|YAP2|YAP65|YKIUBP41|USP9
Cytomap

11q22.1

11q23.3

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional coactivator YAP165 kDa Yes-associated proteinprotein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homologubiquitin carboxyl-terminal hydrolase 241 kDa ubiquitin-specific proteasedeubiquitinating enzyme 2ubiquitin specific protease 12ubiquitin specific protease 9ubiquitin thioesterase 2ubiquitin-specific-processing protease 2
Modification date2018052720180523
UniProtAcc

P46937

O75604

Ensembl transtripts involved in fusion geneENST00000526343, ENST00000282441, 
ENST00000537274, ENST00000345877, 
ENST00000531439, ENST00000524575, 
ENST00000528834, 
ENST00000455332, 
ENST00000260187, ENST00000525735, 
Fusion gene scores* DoF score12 X 6 X 8=5762 X 1 X 2=4
# samples 122
** MAII scorelog2(12/576*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: YAP1 [Title/Abstract] AND USP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYAP1

GO:0006974

cellular response to DNA damage stimulus

18280240

HgeneYAP1

GO:0008283

cell proliferation

17974916

HgeneYAP1

GO:0032570

response to progesterone

16772533

HgeneYAP1

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

16772533

HgeneYAP1

GO:0045893

positive regulation of transcription, DNA-templated

20368466

HgeneYAP1

GO:0045944

positive regulation of transcription by RNA polymerase II

25796446

HgeneYAP1

GO:0050767

regulation of neurogenesis

25433207

HgeneYAP1

GO:0050847

progesterone receptor signaling pathway

16772533

HgeneYAP1

GO:0060242

contact inhibition

17974916

HgeneYAP1

GO:0065003

protein-containing complex assembly

20368466

HgeneYAP1

GO:0071480

cellular response to gamma radiation

18280240

HgeneYAP1

GO:0072091

regulation of stem cell proliferation

25433207

TgeneUSP2

GO:0016579

protein deubiquitination

17290220|19838211|19917254

TgeneUSP2

GO:0050821

protein stabilization

17290220


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-R6-A6XQ-01BYAP1chr11

101985125

+USP2chr11

119230944

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000526343ENST00000455332YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000526343ENST00000260187YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000526343ENST00000525735YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000282441ENST00000455332YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000282441ENST00000260187YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000282441ENST00000525735YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000537274ENST00000455332YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000537274ENST00000260187YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000537274ENST00000525735YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000345877ENST00000455332YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000345877ENST00000260187YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000345877ENST00000525735YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000531439ENST00000455332YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000531439ENST00000260187YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000531439ENST00000525735YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000524575ENST00000455332YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000524575ENST00000260187YAP1chr11

101985125

+USP2chr11

119230944

-
Frame-shiftENST00000524575ENST00000525735YAP1chr11

101985125

+USP2chr11

119230944

-
intron-3CDSENST00000528834ENST00000455332YAP1chr11

101985125

+USP2chr11

119230944

-
intron-3CDSENST00000528834ENST00000260187YAP1chr11

101985125

+USP2chr11

119230944

-
intron-3CDSENST00000528834ENST00000525735YAP1chr11

101985125

+USP2chr11

119230944

-

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FusionProtFeatures for YAP1_USP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YAP1

P46937

USP2

O75604

Hydrolase that deubiquitinates polyubiquitinated targetproteins such as MDM2, MDM4 and CCND1 (PubMed:17290220,PubMed:19917254, PubMed:19838211). Isoform 1 and isoform 4 possessboth ubiquitin-specific peptidase and isopeptidase activities (Bysimilarity). Deubiquitinates MDM2 without reversing MDM2-mediatedp53/TP53 ubiquitination and thus indirectly promotes p53/TP53degradation and limits p53 activity (PubMed:17290220,PubMed:19838211). Has no deubiquitinase activity against p53/TP53(PubMed:17290220). Prevents MDM2-mediated degradation of MDM4(PubMed:17290220). Plays a role in the G1/S cell-cycle progressionin normal and cancer cells (PubMed:19917254). Regulates thecircadian clock by modulating its intrinsic circadian rhythm andits capacity to respond to external cues (By similarity).Associates with clock proteins and deubiquitinates core clockcomponent PER1 but does not affect its overall stability (Bysimilarity). Regulates the nucleocytoplasmic shuttling and nuclearretention of PER1 and its repressive role on the clocktranscription factors CLOCK and ARNTL/BMAL1 (By similarity). Playsa role in the regulation of myogenic differentiation of embryonicmuscle cells (By similarity). {ECO:0000250|UniProtKB:O88623,ECO:0000250|UniProtKB:Q5U349, ECO:0000269|PubMed:17290220,ECO:0000269|PubMed:19838211, ECO:0000269|PubMed:19917254}. Isoform 4: Circadian clock output effector thatregulates Ca(2+) absorption in the small intestine. Probablyfunctions by regulating protein levels of the membrane scaffoldprotein NHERF4 in a rhythmic manner, and is therefore likely tocontrol Ca(2+) membrane permeability mediated by the Ca(2+)channel TRPV6 in the intestine. {ECO:0000250|UniProtKB:O88623}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YAP1_USP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YAP1_USP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
YAP1ERBB4, TP53BP2, KIF5A, SLC9A3R1, YWHAQ, RUNX3, RUNX2, RUNX1, TP73, TP63, WBP1, SMAD7, SMAD6, SCAMP3, AMOT, ITCH, EP300, BTRC, YWHAG, FBXW11, SMAD1, SMAD5, SMAD3, EGFR, ELAVL1, KLF5, LATS2, LATS1, PML, SUMO1, PTPN14, NFE2, POLR2A, AMOTL2, SRSF2, AHCYL1, UBQLN2, SULT1A1, UNK, UBA2, ZFYVE19, VPS4B, PRDX1, IGBP1, THUMPD1, ZPR1, NUBP2, UBE2L3, PIN1, USP9X, TTC9C, UCHL3, UBE2D1, UFM1, UBE2C, UBXN7, VPS25, TEAD1, CREB1, PPP1CA, AMOTL1, ARID1A, ARID1B, ATPIF1, BCL9L, CCDC85C, DPF2, INADL, LIN7C, MPDZ, MPP5, NF2, PARD3, PDLIM7, RAE1, RAPGEF2, RASSF8, SLC9A3R2, SMARCD1, TEAD3, TJP2, WBP2, YWHAB, YWHAE, YWHAH, YWHAZ, MAP2K1, ARFIP1, PAPOLA, PRMT3, RTF1, STAT1, TSNAX, TOM1, FBXW7, ABL1, ENO1, MOV10, NXF1, FAM189B, PRRG4, CYYR1, TEAD4, ARRDC1, LDLRAD4, STUB1, CPVL, ERP44, FASN, HSPH1, HSPA4L, HSPA4, HYOU1, MCMBP, RAPGEF6, PTCH1, PRRG2, NEDD8, TEAD2, XPO1, SMAD2, ENAH, CDH1, PTPN21, DEFA6, BAG4, CTNNB1, NUDT5, PRKD1, XRCC5, XRCC6, AHNAK, EPRS, THBS1, EEF1A1, EEF1A1P5, WWC3, TUBB, HRNR, PFKP, RPL6, COPA, VCP, EIF3B, CAD, RBM10, SUN2, SLC25A5, PSMD2, ACTN1, RRBP1, DDX3X, RPS4X, FAM120A, NCL, CSTF1, TMPO, MAP4, USP15, RPL7A, SNRPB, RPL18, SF3B3, FLG2, HSPB1, CCT2, SND1, PRPF8, EIF4B, HSP90B1, NPM1, PPP2R1A, CYFIP1, MATR3, TUBB6, HNRNPA2B1, RPS6, PSMC2, EIF3L, HNRNPR, IMMT, PHB2, RPS8, PTRF, RPL10A, PARP1, HIST1H1E, LMNB1, PA2G4, HNRNPF, ITGB1, NUMA1, SRSF6, TGM2, OGDH, PDIA3, RPL24, PHGDH, IPO5, TSR1, TRIP6, YBX1, SMARCA4, ATAD3A, RPL19, CCT5, PGAM5, SEC16A, AJUBA, PSMC5, UPF1, RPL15, XRN2, RPL13A, PSMC6, CNN2, HDAC1, HDAC2, SFN, SUPT16H, RBBP7, PRDX6, SEPT2, UQCRC2, MVD, MYH10, PLOD2, PSMD6, ADSS, PAICS, FUBP1, CIAPIN1, SFXN1, PSMA5, RPL9, DNAJC10, PTBP1, ANXA5, KPNA2, WDR1, C11orf84, H2AFY, JUN, RTN4, RPL14, H1FX, IGFBP7, ACTL6A, RPL17, ZYX, PSMB4, TWF1, HIST1H1B, TK1, CDC20, RAN, RPL21, SV2B, HN1LUSP2HOOK2, BEND5, CCDC85B, KRT15, TRAF2, BEGAIN, NFKB2, LONP1, RRP15, UBC, FASN, SCNN1A, SCNN1G, PRKAA1, CCND1, MDM4, MDM2, KCNQ1, RIPK1, TRADD, TNFRSF1A, CASP8, UBE2S, TRAF6, CCNA1, EGFR, CRY1, AURKA, SCNN1B, TRIM63, TRIM54, USP21, APP, BRCA1, MNAT1, TRIM21, TRAIP, RBCK1, UBOX5, TRIM35, TRIM27, TRIM34, RNF125, RNF126, TRIM39, TRIM46, TRIM8, PCGF6, TRIM5, LRSAM1, LONRF1, TRIM9, RNF166, DTX3, LNX2, RNF144B, TRIM74, TRIM23, CBLC, CARD11, MALT1, MAP3K7, IKBKG, ZNF598, RNF11, BAP1, MAP3K2, RAD18, PLA2G2A, ERBB2, GOLGA2, KIFC3, NEFL, VPS52, PNMA1, HOMER3, MTUS2, HOOK1, CCDC136, NDEL1, LZTS2, LHX4, KRT40, CCDC57, CCDC36, CACNA2D2, MOV10, NXF1, PCNA, TBK1, PIK3R3, MYLIP, LDLR, HIST2H2AC, PEX5, VCAM1, PALB2, ENPP1, TMEM173, ZAP70, MYC, LMNA, STAT1, IL1RL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YAP1_USP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for YAP1_USP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneYAP1C0027819Neuroblastoma1CTD_human
HgeneYAP1C0919267ovarian neoplasm1CTD_human
HgeneYAP1C1168401Squamous cell carcinoma of the head and neck1CTD_human
TgeneUSP2C2239176Liver carcinoma1CTD_human