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Fusion gene ID: 42283 |
FusionGeneSummary for YAP1_USP2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: YAP1_USP2 | Fusion gene ID: 42283 | Hgene | Tgene | Gene symbol | YAP1 | USP2 | Gene ID | 10413 | 9099 |
Gene name | Yes associated protein 1 | ubiquitin specific peptidase 2 | |
Synonyms | COB1|YAP|YAP2|YAP65|YKI | UBP41|USP9 | |
Cytomap | 11q22.1 | 11q23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transcriptional coactivator YAP165 kDa Yes-associated proteinprotein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog | ubiquitin carboxyl-terminal hydrolase 241 kDa ubiquitin-specific proteasedeubiquitinating enzyme 2ubiquitin specific protease 12ubiquitin specific protease 9ubiquitin thioesterase 2ubiquitin-specific-processing protease 2 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P46937 | O75604 | |
Ensembl transtripts involved in fusion gene | ENST00000526343, ENST00000282441, ENST00000537274, ENST00000345877, ENST00000531439, ENST00000524575, ENST00000528834, | ENST00000455332, ENST00000260187, ENST00000525735, | |
Fusion gene scores | * DoF score | 12 X 6 X 8=576 | 2 X 1 X 2=4 |
# samples | 12 | 2 | |
** MAII score | log2(12/576*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: YAP1 [Title/Abstract] AND USP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | YAP1 | GO:0006974 | cellular response to DNA damage stimulus | 18280240 |
Hgene | YAP1 | GO:0008283 | cell proliferation | 17974916 |
Hgene | YAP1 | GO:0032570 | response to progesterone | 16772533 |
Hgene | YAP1 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway | 16772533 |
Hgene | YAP1 | GO:0045893 | positive regulation of transcription, DNA-templated | 20368466 |
Hgene | YAP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 25796446 |
Hgene | YAP1 | GO:0050767 | regulation of neurogenesis | 25433207 |
Hgene | YAP1 | GO:0050847 | progesterone receptor signaling pathway | 16772533 |
Hgene | YAP1 | GO:0060242 | contact inhibition | 17974916 |
Hgene | YAP1 | GO:0065003 | protein-containing complex assembly | 20368466 |
Hgene | YAP1 | GO:0071480 | cellular response to gamma radiation | 18280240 |
Hgene | YAP1 | GO:0072091 | regulation of stem cell proliferation | 25433207 |
Tgene | USP2 | GO:0016579 | protein deubiquitination | 17290220|19838211|19917254 |
Tgene | USP2 | GO:0050821 | protein stabilization | 17290220 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-R6-A6XQ-01B | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000526343 | ENST00000455332 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000526343 | ENST00000260187 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000526343 | ENST00000525735 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000282441 | ENST00000455332 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000282441 | ENST00000260187 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000282441 | ENST00000525735 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000537274 | ENST00000455332 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000537274 | ENST00000260187 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000537274 | ENST00000525735 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000345877 | ENST00000455332 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000345877 | ENST00000260187 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000345877 | ENST00000525735 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000531439 | ENST00000455332 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000531439 | ENST00000260187 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000531439 | ENST00000525735 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000524575 | ENST00000455332 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000524575 | ENST00000260187 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
Frame-shift | ENST00000524575 | ENST00000525735 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
intron-3CDS | ENST00000528834 | ENST00000455332 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
intron-3CDS | ENST00000528834 | ENST00000260187 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
intron-3CDS | ENST00000528834 | ENST00000525735 | YAP1 | chr11 | 101985125 | + | USP2 | chr11 | 119230944 | - |
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FusionProtFeatures for YAP1_USP2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
YAP1 | USP2 |
Hydrolase that deubiquitinates polyubiquitinated targetproteins such as MDM2, MDM4 and CCND1 (PubMed:17290220,PubMed:19917254, PubMed:19838211). Isoform 1 and isoform 4 possessboth ubiquitin-specific peptidase and isopeptidase activities (Bysimilarity). Deubiquitinates MDM2 without reversing MDM2-mediatedp53/TP53 ubiquitination and thus indirectly promotes p53/TP53degradation and limits p53 activity (PubMed:17290220,PubMed:19838211). Has no deubiquitinase activity against p53/TP53(PubMed:17290220). Prevents MDM2-mediated degradation of MDM4(PubMed:17290220). Plays a role in the G1/S cell-cycle progressionin normal and cancer cells (PubMed:19917254). Regulates thecircadian clock by modulating its intrinsic circadian rhythm andits capacity to respond to external cues (By similarity).Associates with clock proteins and deubiquitinates core clockcomponent PER1 but does not affect its overall stability (Bysimilarity). Regulates the nucleocytoplasmic shuttling and nuclearretention of PER1 and its repressive role on the clocktranscription factors CLOCK and ARNTL/BMAL1 (By similarity). Playsa role in the regulation of myogenic differentiation of embryonicmuscle cells (By similarity). {ECO:0000250|UniProtKB:O88623,ECO:0000250|UniProtKB:Q5U349, ECO:0000269|PubMed:17290220,ECO:0000269|PubMed:19838211, ECO:0000269|PubMed:19917254}. Isoform 4: Circadian clock output effector thatregulates Ca(2+) absorption in the small intestine. Probablyfunctions by regulating protein levels of the membrane scaffoldprotein NHERF4 in a rhythmic manner, and is therefore likely tocontrol Ca(2+) membrane permeability mediated by the Ca(2+)channel TRPV6 in the intestine. {ECO:0000250|UniProtKB:O88623}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for YAP1_USP2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for YAP1_USP2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
YAP1 | ERBB4, TP53BP2, KIF5A, SLC9A3R1, YWHAQ, RUNX3, RUNX2, RUNX1, TP73, TP63, WBP1, SMAD7, SMAD6, SCAMP3, AMOT, ITCH, EP300, BTRC, YWHAG, FBXW11, SMAD1, SMAD5, SMAD3, EGFR, ELAVL1, KLF5, LATS2, LATS1, PML, SUMO1, PTPN14, NFE2, POLR2A, AMOTL2, SRSF2, AHCYL1, UBQLN2, SULT1A1, UNK, UBA2, ZFYVE19, VPS4B, PRDX1, IGBP1, THUMPD1, ZPR1, NUBP2, UBE2L3, PIN1, USP9X, TTC9C, UCHL3, UBE2D1, UFM1, UBE2C, UBXN7, VPS25, TEAD1, CREB1, PPP1CA, AMOTL1, ARID1A, ARID1B, ATPIF1, BCL9L, CCDC85C, DPF2, INADL, LIN7C, MPDZ, MPP5, NF2, PARD3, PDLIM7, RAE1, RAPGEF2, RASSF8, SLC9A3R2, SMARCD1, TEAD3, TJP2, WBP2, YWHAB, YWHAE, YWHAH, YWHAZ, MAP2K1, ARFIP1, PAPOLA, PRMT3, RTF1, STAT1, TSNAX, TOM1, FBXW7, ABL1, ENO1, MOV10, NXF1, FAM189B, PRRG4, CYYR1, TEAD4, ARRDC1, LDLRAD4, STUB1, CPVL, ERP44, FASN, HSPH1, HSPA4L, HSPA4, HYOU1, MCMBP, RAPGEF6, PTCH1, PRRG2, NEDD8, TEAD2, XPO1, SMAD2, ENAH, CDH1, PTPN21, DEFA6, BAG4, CTNNB1, NUDT5, PRKD1, XRCC5, XRCC6, AHNAK, EPRS, THBS1, EEF1A1, EEF1A1P5, WWC3, TUBB, HRNR, PFKP, RPL6, COPA, VCP, EIF3B, CAD, RBM10, SUN2, SLC25A5, PSMD2, ACTN1, RRBP1, DDX3X, RPS4X, FAM120A, NCL, CSTF1, TMPO, MAP4, USP15, RPL7A, SNRPB, RPL18, SF3B3, FLG2, HSPB1, CCT2, SND1, PRPF8, EIF4B, HSP90B1, NPM1, PPP2R1A, CYFIP1, MATR3, TUBB6, HNRNPA2B1, RPS6, PSMC2, EIF3L, HNRNPR, IMMT, PHB2, RPS8, PTRF, RPL10A, PARP1, HIST1H1E, LMNB1, PA2G4, HNRNPF, ITGB1, NUMA1, SRSF6, TGM2, OGDH, PDIA3, RPL24, PHGDH, IPO5, TSR1, TRIP6, YBX1, SMARCA4, ATAD3A, RPL19, CCT5, PGAM5, SEC16A, AJUBA, PSMC5, UPF1, RPL15, XRN2, RPL13A, PSMC6, CNN2, HDAC1, HDAC2, SFN, SUPT16H, RBBP7, PRDX6, SEPT2, UQCRC2, MVD, MYH10, PLOD2, PSMD6, ADSS, PAICS, FUBP1, CIAPIN1, SFXN1, PSMA5, RPL9, DNAJC10, PTBP1, ANXA5, KPNA2, WDR1, C11orf84, H2AFY, JUN, RTN4, RPL14, H1FX, IGFBP7, ACTL6A, RPL17, ZYX, PSMB4, TWF1, HIST1H1B, TK1, CDC20, RAN, RPL21, SV2B, HN1L | USP2 | HOOK2, BEND5, CCDC85B, KRT15, TRAF2, BEGAIN, NFKB2, LONP1, RRP15, UBC, FASN, SCNN1A, SCNN1G, PRKAA1, CCND1, MDM4, MDM2, KCNQ1, RIPK1, TRADD, TNFRSF1A, CASP8, UBE2S, TRAF6, CCNA1, EGFR, CRY1, AURKA, SCNN1B, TRIM63, TRIM54, USP21, APP, BRCA1, MNAT1, TRIM21, TRAIP, RBCK1, UBOX5, TRIM35, TRIM27, TRIM34, RNF125, RNF126, TRIM39, TRIM46, TRIM8, PCGF6, TRIM5, LRSAM1, LONRF1, TRIM9, RNF166, DTX3, LNX2, RNF144B, TRIM74, TRIM23, CBLC, CARD11, MALT1, MAP3K7, IKBKG, ZNF598, RNF11, BAP1, MAP3K2, RAD18, PLA2G2A, ERBB2, GOLGA2, KIFC3, NEFL, VPS52, PNMA1, HOMER3, MTUS2, HOOK1, CCDC136, NDEL1, LZTS2, LHX4, KRT40, CCDC57, CCDC36, CACNA2D2, MOV10, NXF1, PCNA, TBK1, PIK3R3, MYLIP, LDLR, HIST2H2AC, PEX5, VCAM1, PALB2, ENPP1, TMEM173, ZAP70, MYC, LMNA, STAT1, IL1RL2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YAP1_USP2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YAP1_USP2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | YAP1 | C0027819 | Neuroblastoma | 1 | CTD_human |
Hgene | YAP1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | YAP1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
Tgene | USP2 | C2239176 | Liver carcinoma | 1 | CTD_human |