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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42269

FusionGeneSummary for YAF2_DMTF1

check button Fusion gene summary
Fusion gene informationFusion gene name: YAF2_DMTF1
Fusion gene ID: 42269
HgeneTgene
Gene symbol

YAF2

DMTF1

Gene ID

10138

9988

Gene nameYY1 associated factor 2cyclin D binding myb like transcription factor 1
Synonyms-DMP1|DMTF|MRUL|hDMP1
Cytomap

12q12

7q21.12

Type of geneprotein-codingprotein-coding
DescriptionYY1-associated factor 2cyclin-D-binding Myb-like transcription factor 1cyclin D-binding Myb-like proteincyclin-D-interacting Myb-like protein 1hDMTF1
Modification date2018051920180523
UniProtAcc

Q8IY57

Q9Y222

Ensembl transtripts involved in fusion geneENST00000327791, ENST00000442791, 
ENST00000534854, ENST00000380790, 
ENST00000380788, ENST00000541702, 
ENST00000555248, 
ENST00000394702, 
ENST00000331242, ENST00000413276, 
ENST00000411766, ENST00000432937, 
ENST00000394703, ENST00000580710, 
ENST00000414194, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 4 X 3=48
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YAF2 [Title/Abstract] AND DMTF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYAF2

GO:0045892

negative regulation of transcription, DNA-templated

12706874

HgeneYAF2

GO:0045893

positive regulation of transcription, DNA-templated

11593398


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AU253133YAF2chr12

42610511

-DMTF1chr7

86822574

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000327791ENST00000394702YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000327791ENST00000331242YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000327791ENST00000413276YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000327791ENST00000411766YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000327791ENST00000432937YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000327791ENST00000394703YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000327791ENST00000580710YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000327791ENST00000414194YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000442791ENST00000394702YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000442791ENST00000331242YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000442791ENST00000413276YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000442791ENST00000411766YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000442791ENST00000432937YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000442791ENST00000394703YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000442791ENST00000580710YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000442791ENST00000414194YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000534854ENST00000394702YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000534854ENST00000331242YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000534854ENST00000413276YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000534854ENST00000411766YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000534854ENST00000432937YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000534854ENST00000394703YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000534854ENST00000580710YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000534854ENST00000414194YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380790ENST00000394702YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380790ENST00000331242YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380790ENST00000413276YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380790ENST00000411766YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380790ENST00000432937YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380790ENST00000394703YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380790ENST00000580710YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380790ENST00000414194YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380788ENST00000394702YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380788ENST00000331242YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380788ENST00000413276YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380788ENST00000411766YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380788ENST00000432937YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380788ENST00000394703YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380788ENST00000580710YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000380788ENST00000414194YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000541702ENST00000394702YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000541702ENST00000331242YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000541702ENST00000413276YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000541702ENST00000411766YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000541702ENST00000432937YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000541702ENST00000394703YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000541702ENST00000580710YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000541702ENST00000414194YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000555248ENST00000394702YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000555248ENST00000331242YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000555248ENST00000413276YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000555248ENST00000411766YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000555248ENST00000432937YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000555248ENST00000394703YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000555248ENST00000580710YAF2chr12

42610511

-DMTF1chr7

86822574

+
intron-intronENST00000555248ENST00000414194YAF2chr12

42610511

-DMTF1chr7

86822574

+

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FusionProtFeatures for YAF2_DMTF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YAF2

Q8IY57

DMTF1

Q9Y222

Binds to MYC and inhibits MYC-mediated transactivation.Also binds to MYCN and enhances MYCN-dependent transcriptionalactivation. Increases calpain 2-mediated proteolysis of YY1 invitro. Component of the E2F6.com-1 complex, a repressive complexthat methylates 'Lys-9' of histone H3, suggesting that it isinvolved in chromatin-remodeling. {ECO:0000269|PubMed:11593398,ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YAF2_DMTF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YAF2_DMTF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YAF2_DMTF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for YAF2_DMTF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource