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Fusion gene ID: 42261 |
FusionGeneSummary for XYLT1_GALNT6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: XYLT1_GALNT6 | Fusion gene ID: 42261 | Hgene | Tgene | Gene symbol | XYLT1 | GALNT6 | Gene ID | 64131 | 11226 |
| Gene name | xylosyltransferase 1 | polypeptide N-acetylgalactosaminyltransferase 6 | |
| Synonyms | DBQD2|PXYLT1|XT-I|XT1|XTI|XYLTI|xylT-I | GALNAC-T6|GalNAcT6 | |
| Cytomap | 16p12.3 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | xylosyltransferase 1beta-D-xylosyltransferase 1peptide O-xylosyltransferase 1xylosyltransferase Ixylosyltransferase iota | polypeptide N-acetylgalactosaminyltransferase 6GalNAc transferase 6UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 6UDP-N-acetyl-alpha-D-galactosamine:polypept | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q86Y38 | Q8NCL4 | |
| Ensembl transtripts involved in fusion gene | ENST00000261381, ENST00000568226, | ENST00000543196, ENST00000356317, ENST00000603203, | |
| Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 3 X 3 X 2=18 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/112*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: XYLT1 [Title/Abstract] AND GALNT6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A1KU-01A | XYLT1 | chr16 | 17292069 | - | GALNT6 | chr12 | 51771151 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261381 | ENST00000543196 | XYLT1 | chr16 | 17292069 | - | GALNT6 | chr12 | 51771151 | - |
| In-frame | ENST00000261381 | ENST00000356317 | XYLT1 | chr16 | 17292069 | - | GALNT6 | chr12 | 51771151 | - |
| 5CDS-intron | ENST00000261381 | ENST00000603203 | XYLT1 | chr16 | 17292069 | - | GALNT6 | chr12 | 51771151 | - |
| intron-3CDS | ENST00000568226 | ENST00000543196 | XYLT1 | chr16 | 17292069 | - | GALNT6 | chr12 | 51771151 | - |
| intron-3CDS | ENST00000568226 | ENST00000356317 | XYLT1 | chr16 | 17292069 | - | GALNT6 | chr12 | 51771151 | - |
| intron-intron | ENST00000568226 | ENST00000603203 | XYLT1 | chr16 | 17292069 | - | GALNT6 | chr12 | 51771151 | - |
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FusionProtFeatures for XYLT1_GALNT6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| XYLT1 | GALNT6 |
| Catalyzes the first step in the biosynthesis ofchondroitin sulfate and dermatan sulfate proteoglycans, such asDCN. Transfers D-xylose from UDP-D-xylose to specific serineresidues of the core protein (PubMed:15461586, PubMed:17189265,PubMed:24581741, PubMed:23982343). Required for normal embryonicand postnatal skeleton development, especially of the long bones(PubMed:24581741, PubMed:23982343). Required for normal maturationof chondrocytes during bone development, and normal onset ofossification (By similarity). {ECO:0000250|UniProtKB:Q811B1,ECO:0000269|PubMed:15461586, ECO:0000269|PubMed:17189265,ECO:0000269|PubMed:23982343, ECO:0000269|PubMed:24581741}. | Catalyzes the initial reaction in O-linkedoligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on theprotein receptor. May participate in synthesis of oncofetalfibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectinpeptides. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | XYLT1 | chr16:17292069 | chr12:51771151 | ENST00000261381 | - | 5 | 12 | 390_392 | 429 | 960 | Region | UDP-xylose binding |
| Hgene | XYLT1 | chr16:17292069 | chr12:51771151 | ENST00000261381 | - | 5 | 12 | 1_17 | 429 | 960 | Topological domain | Cytoplasmic |
| Hgene | XYLT1 | chr16:17292069 | chr12:51771151 | ENST00000261381 | - | 5 | 12 | 18_38 | 429 | 960 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | >GALNT6 | chr16:17292069 | chr12:51771151 | ENST00000356317 | - | 2 | 12 | 496_622 | 163 | 623 | Domain | Ricin B-type lectin |
| Tgene | >GALNT6 | chr16:17292069 | chr12:51771151 | ENST00000543196 | - | 1 | 11 | 496_622 | 163 | 623 | Domain | Ricin B-type lectin |
| Tgene | >GALNT6 | chr16:17292069 | chr12:51771151 | ENST00000356317 | - | 2 | 12 | 176_285 | 163 | 623 | Region | Note=Catalytic subdomain A |
| Tgene | >GALNT6 | chr16:17292069 | chr12:51771151 | ENST00000356317 | - | 2 | 12 | 348_410 | 163 | 623 | Region | Note=Catalytic subdomain B |
| Tgene | >GALNT6 | chr16:17292069 | chr12:51771151 | ENST00000543196 | - | 1 | 11 | 176_285 | 163 | 623 | Region | Note=Catalytic subdomain A |
| Tgene | >GALNT6 | chr16:17292069 | chr12:51771151 | ENST00000543196 | - | 1 | 11 | 348_410 | 163 | 623 | Region | Note=Catalytic subdomain B |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >XYLT1 | chr16:17292069 | chr12:51771151 | ENST00000261381 | - | 5 | 12 | 494_495 | 429 | 960 | Region | UDP-xylose binding |
| Hgene | >XYLT1 | chr16:17292069 | chr12:51771151 | ENST00000261381 | - | 5 | 12 | 598_599 | 429 | 960 | Region | UDP-xylose binding |
| Hgene | >XYLT1 | chr16:17292069 | chr12:51771151 | ENST00000261381 | - | 5 | 12 | 39_959 | 429 | 960 | Topological domain | Lumenal |
| Tgene | GALNT6 | chr16:17292069 | chr12:51771151 | ENST00000356317 | - | 2 | 12 | 1_8 | 163 | 623 | Topological domain | Cytoplasmic |
| Tgene | GALNT6 | chr16:17292069 | chr12:51771151 | ENST00000356317 | - | 2 | 12 | 29_622 | 163 | 623 | Topological domain | Lumenal |
| Tgene | GALNT6 | chr16:17292069 | chr12:51771151 | ENST00000543196 | - | 1 | 11 | 1_8 | 163 | 623 | Topological domain | Cytoplasmic |
| Tgene | GALNT6 | chr16:17292069 | chr12:51771151 | ENST00000543196 | - | 1 | 11 | 29_622 | 163 | 623 | Topological domain | Lumenal |
| Tgene | GALNT6 | chr16:17292069 | chr12:51771151 | ENST00000356317 | - | 2 | 12 | 9_28 | 163 | 623 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | GALNT6 | chr16:17292069 | chr12:51771151 | ENST00000543196 | - | 1 | 11 | 9_28 | 163 | 623 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for XYLT1_GALNT6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_XYLT1_ENST00000261381_chr16_17292069_-_GALNT6_ENST00000543196_chr12_51771151_-_889aa MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGG RGPQARARGGGPGEPRGQQPASRGALPARALDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPE LAKKPPSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLPPGDRAAANSSHGKDVSRPPHARKTGGSSPETKYDQPPKCDISGKEAISALSR AKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHV DKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRCVDQKFRRCPPLATTSVIIV FHNEAWSTLLRTVYSVLHTTPAILLKEIILVDDASTEEHLKEKLEQYVKQLQVVRVVRQEERKGLITARLLGASVAQAEVLTFLDAHCEC FHGWLEPLLARIAEDKTVVVSPDIVTIDLNTFEFAKPVQRGRVHSRGNFDWSLTFGWETLPPHEKQRRKDETYPIKSPTFAGGLFSISKS YFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKGTSVIARNQVRLAEVWMDSYKKIFYRRNLQAAKMA QEKSFGDISERLQLREQLHCHNFSWYLHNVYPEMFVPDLTPTFYGAIKNLGTNQCLDVGENNRGGKPLIMYSCHGLGGNQYFEYTTQRDL >In-frame_XYLT1_ENST00000261381_chr16_17292069_-_GALNT6_ENST00000356317_chr12_51771151_-_889aa MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGG RGPQARARGGGPGEPRGQQPASRGALPARALDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPE LAKKPPSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLPPGDRAAANSSHGKDVSRPPHARKTGGSSPETKYDQPPKCDISGKEAISALSR AKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHV DKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRCVDQKFRRCPPLATTSVIIV FHNEAWSTLLRTVYSVLHTTPAILLKEIILVDDASTEEHLKEKLEQYVKQLQVVRVVRQEERKGLITARLLGASVAQAEVLTFLDAHCEC FHGWLEPLLARIAEDKTVVVSPDIVTIDLNTFEFAKPVQRGRVHSRGNFDWSLTFGWETLPPHEKQRRKDETYPIKSPTFAGGLFSISKS YFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKGTSVIARNQVRLAEVWMDSYKKIFYRRNLQAAKMA QEKSFGDISERLQLREQLHCHNFSWYLHNVYPEMFVPDLTPTFYGAIKNLGTNQCLDVGENNRGGKPLIMYSCHGLGGNQYFEYTTQRDL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_XYLT1_ENST00000261381_chr16_17292069_-_GALNT6_ENST00000543196_chr12_51771151_-_2667nt ATGGTGGCGGCGCCGTGCGCCCGGAGGCTGGCCCGGCGCTCGCACTCGGCGCTGCTCGCGGCGCTCACGGTGCTGCTGCTGCAGACGCTG GTCGTGTGGAATTTCAGCAGCCTCGACTCCGGGGCCGGGGAGCGCCGCGGGGGCGCAGCGGTCGGCGGCGGGGAGCAGCCGCCCCCGGCC CCGGCCCCGCGCCGGGAGCGCCGGGACCTGCCCGCCGAGCCGGCTGCAGCCCGAGGAGGAGGAGGAGGCGGCGGCGGAGGAGGAGGAGGA CGGGGGCCCCAGGCGCGGGCGCGGGGAGGCGGCCCCGGAGAACCGCGGGGACAGCAGCCGGCCAGCCGGGGGGCACTGCCCGCCCGGGCT CTGGATCCACACCCAAGTCCGCTCATCACCCTGGAGACTCAGGATGGCTACTTTTCTCATCGGCCGAAAGAGAAAGTGCGAACAGACAGC AACAACGAGAACTCTGTCCCCAAAGACTTTGAGAATGTCGACAACAGCAACTTCGCACCCAGGACTCAAAAGCAGAAGCACCAGCCTGAG TTGGCGAAGAAGCCACCGAGTAGACAGAAGGAGCTTTTGAAAAGGAAGCTGGAACAGCAGGAGAAAGGAAAAGGACATACATTCCCTGGG AAAGGCCCCGGTGAGGTGCTGCCTCCCGGGGACAGAGCCGCAGCCAACAGCAGCCACGGGAAGGATGTGTCCAGACCGCCTCATGCCAGG AAAACTGGGGGCAGCTCCCCCGAGACCAAGTATGACCAGCCCCCTAAGTGTGACATCTCAGGCAAGGAGGCCATCTCTGCCCTGTCCCGT GCTAAGTCCAAGCACTGCCGCCAGGAGATTGGGGAGACTTACTGCCGCCACAAGTTAGGGCTGCTGATGCCTGAGAAGGTGACTCGGTTC TGCCCCCTCGAGGGTAAAGCCAACAAGAACGTGCAGTGGGACGAGGACTCCGTGGAGTACATGCCAGCCAACCCGGTCAGAATCGCCTTT GTCCTGGTGGTCCACGGCCGTGCCTCTCGGCAGTTGCAGCGCATGTTCAAGGCCATCTACCACAAAGACCACTTCTACTACATCCACGTG GACAAGCGCTCTAATTACCTGCATCGGCAAGTGCTCCAGGTCTCCAGGCAGTACAGCAATGTCCGCGTCACCCCCTGGAGAATGGCCACC ATCTGGGGAGGAGCCAGCCTCCTGTCCACCTACCTGCAGAGCATGCGGGACCTCCTGGAGATGACCGACTGGCCCTGGGACTTCTTCATC AACCTGAGTGCGGCCGACTACCCCATCAGGTGTGTGGACCAGAAGTTCCGGCGCTGCCCCCCACTGGCCACCACCAGCGTGATCATTGTG TTCCACAACGAAGCCTGGTCCACACTGCTGCGAACAGTGTACAGCGTCCTACACACCACCCCTGCCATCTTGCTCAAGGAGATCATACTG GTGGATGATGCCAGCACAGAGGAGCACCTAAAGGAGAAGCTGGAGCAGTACGTGAAGCAGCTGCAGGTGGTGAGGGTGGTGCGGCAGGAG GAGCGGAAGGGGCTGATCACCGCCCGGCTGCTGGGGGCCAGCGTGGCACAGGCGGAGGTGCTCACGTTCCTGGATGCCCACTGTGAGTGC TTCCACGGCTGGCTGGAGCCCCTCCTGGCTCGAATCGCTGAGGACAAGACAGTGGTGGTGAGCCCAGACATCGTCACCATCGACCTTAAT ACTTTTGAGTTCGCCAAGCCCGTCCAGAGGGGCAGAGTCCATAGCCGAGGCAACTTTGACTGGAGCCTGACCTTCGGCTGGGAAACACTT CCTCCACATGAGAAGCAGAGGCGCAAGGATGAAACCTACCCCATCAAATCCCCGACGTTTGCTGGTGGCCTCTTCTCCATCTCCAAGTCC TACTTTGAGCACATCGGTACCTATGATAATCAGATGGAGATCTGGGGAGGGGAGAACGTGGAAATGTCCTTCCGGGTGTGGCAGTGTGGG GGCCAGCTGGAGATCATCCCCTGCTCTGTCGTAGGCCATGTGTTCCGGACCAAGAGCCCCCACACCTTCCCCAAGGGCACTAGTGTCATT GCTCGCAATCAAGTGCGCCTGGCAGAGGTCTGGATGGACAGCTACAAGAAGATTTTCTATAGGAGAAATCTGCAGGCAGCAAAGATGGCC CAAGAGAAATCCTTCGGTGACATTTCGGAACGACTGCAGCTGAGGGAACAACTGCACTGTCACAACTTTTCCTGGTACCTGCACAATGTC TACCCAGAGATGTTTGTTCCTGACCTGACGCCCACCTTCTATGGTGCCATCAAGAACCTCGGCACCAACCAATGCCTGGATGTGGGTGAG AACAACCGCGGGGGGAAGCCCCTCATCATGTACTCCTGCCACGGCCTTGGCGGCAACCAGTACTTTGAGTACACAACTCAGAGGGACCTT CGCCACAACATCGCAAAGCAGCTGTGTCTACATGTCAGCAAGGGTGCTCTGGGCCTTGGGAGCTGTCACTTCACTGGCAAGAATAGCCAG GTCCCCAAGGACGAGGAATGGGAATTGGCCCAGGATCAGCTCATCAGGAACTCAGGATCTGGTACCTGCCTGACATCCCAGGACAAAAAG >In-frame_XYLT1_ENST00000261381_chr16_17292069_-_GALNT6_ENST00000356317_chr12_51771151_-_2667nt ATGGTGGCGGCGCCGTGCGCCCGGAGGCTGGCCCGGCGCTCGCACTCGGCGCTGCTCGCGGCGCTCACGGTGCTGCTGCTGCAGACGCTG GTCGTGTGGAATTTCAGCAGCCTCGACTCCGGGGCCGGGGAGCGCCGCGGGGGCGCAGCGGTCGGCGGCGGGGAGCAGCCGCCCCCGGCC CCGGCCCCGCGCCGGGAGCGCCGGGACCTGCCCGCCGAGCCGGCTGCAGCCCGAGGAGGAGGAGGAGGCGGCGGCGGAGGAGGAGGAGGA CGGGGGCCCCAGGCGCGGGCGCGGGGAGGCGGCCCCGGAGAACCGCGGGGACAGCAGCCGGCCAGCCGGGGGGCACTGCCCGCCCGGGCT CTGGATCCACACCCAAGTCCGCTCATCACCCTGGAGACTCAGGATGGCTACTTTTCTCATCGGCCGAAAGAGAAAGTGCGAACAGACAGC AACAACGAGAACTCTGTCCCCAAAGACTTTGAGAATGTCGACAACAGCAACTTCGCACCCAGGACTCAAAAGCAGAAGCACCAGCCTGAG TTGGCGAAGAAGCCACCGAGTAGACAGAAGGAGCTTTTGAAAAGGAAGCTGGAACAGCAGGAGAAAGGAAAAGGACATACATTCCCTGGG AAAGGCCCCGGTGAGGTGCTGCCTCCCGGGGACAGAGCCGCAGCCAACAGCAGCCACGGGAAGGATGTGTCCAGACCGCCTCATGCCAGG AAAACTGGGGGCAGCTCCCCCGAGACCAAGTATGACCAGCCCCCTAAGTGTGACATCTCAGGCAAGGAGGCCATCTCTGCCCTGTCCCGT GCTAAGTCCAAGCACTGCCGCCAGGAGATTGGGGAGACTTACTGCCGCCACAAGTTAGGGCTGCTGATGCCTGAGAAGGTGACTCGGTTC TGCCCCCTCGAGGGTAAAGCCAACAAGAACGTGCAGTGGGACGAGGACTCCGTGGAGTACATGCCAGCCAACCCGGTCAGAATCGCCTTT GTCCTGGTGGTCCACGGCCGTGCCTCTCGGCAGTTGCAGCGCATGTTCAAGGCCATCTACCACAAAGACCACTTCTACTACATCCACGTG GACAAGCGCTCTAATTACCTGCATCGGCAAGTGCTCCAGGTCTCCAGGCAGTACAGCAATGTCCGCGTCACCCCCTGGAGAATGGCCACC ATCTGGGGAGGAGCCAGCCTCCTGTCCACCTACCTGCAGAGCATGCGGGACCTCCTGGAGATGACCGACTGGCCCTGGGACTTCTTCATC AACCTGAGTGCGGCCGACTACCCCATCAGGTGTGTGGACCAGAAGTTCCGGCGCTGCCCCCCACTGGCCACCACCAGCGTGATCATTGTG TTCCACAACGAAGCCTGGTCCACACTGCTGCGAACAGTGTACAGCGTCCTACACACCACCCCTGCCATCTTGCTCAAGGAGATCATACTG GTGGATGATGCCAGCACAGAGGAGCACCTAAAGGAGAAGCTGGAGCAGTACGTGAAGCAGCTGCAGGTGGTGAGGGTGGTGCGGCAGGAG GAGCGGAAGGGGCTGATCACCGCCCGGCTGCTGGGGGCCAGCGTGGCACAGGCGGAGGTGCTCACGTTCCTGGATGCCCACTGTGAGTGC TTCCACGGCTGGCTGGAGCCCCTCCTGGCTCGAATCGCTGAGGACAAGACAGTGGTGGTGAGCCCAGACATCGTCACCATCGACCTTAAT ACTTTTGAGTTCGCCAAGCCCGTCCAGAGGGGCAGAGTCCATAGCCGAGGCAACTTTGACTGGAGCCTGACCTTCGGCTGGGAAACACTT CCTCCACATGAGAAGCAGAGGCGCAAGGATGAAACCTACCCCATCAAATCCCCGACGTTTGCTGGTGGCCTCTTCTCCATCTCCAAGTCC TACTTTGAGCACATCGGTACCTATGATAATCAGATGGAGATCTGGGGAGGGGAGAACGTGGAAATGTCCTTCCGGGTGTGGCAGTGTGGG GGCCAGCTGGAGATCATCCCCTGCTCTGTCGTAGGCCATGTGTTCCGGACCAAGAGCCCCCACACCTTCCCCAAGGGCACTAGTGTCATT GCTCGCAATCAAGTGCGCCTGGCAGAGGTCTGGATGGACAGCTACAAGAAGATTTTCTATAGGAGAAATCTGCAGGCAGCAAAGATGGCC CAAGAGAAATCCTTCGGTGACATTTCGGAACGACTGCAGCTGAGGGAACAACTGCACTGTCACAACTTTTCCTGGTACCTGCACAATGTC TACCCAGAGATGTTTGTTCCTGACCTGACGCCCACCTTCTATGGTGCCATCAAGAACCTCGGCACCAACCAATGCCTGGATGTGGGTGAG AACAACCGCGGGGGGAAGCCCCTCATCATGTACTCCTGCCACGGCCTTGGCGGCAACCAGTACTTTGAGTACACAACTCAGAGGGACCTT CGCCACAACATCGCAAAGCAGCTGTGTCTACATGTCAGCAAGGGTGCTCTGGGCCTTGGGAGCTGTCACTTCACTGGCAAGAATAGCCAG GTCCCCAAGGACGAGGAATGGGAATTGGCCCAGGATCAGCTCATCAGGAACTCAGGATCTGGTACCTGCCTGACATCCCAGGACAAAAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_XYLT1_ENST00000261381_chr16_17292069_-_GALNT6_ENST00000543196_chr12_51771151_-_5884nt GCGGCCGCGGGAGCTGCGGGGAGCGCGGGGGCGGCCCGGAGCGTGCCGGGGTCCCCGCGCCTCGCTCGCCGGCCGCGCTCCGAAGATGGT GGCGGCGCCGTGCGCCCGGAGGCTGGCCCGGCGCTCGCACTCGGCGCTGCTCGCGGCGCTCACGGTGCTGCTGCTGCAGACGCTGGTCGT GTGGAATTTCAGCAGCCTCGACTCCGGGGCCGGGGAGCGCCGCGGGGGCGCAGCGGTCGGCGGCGGGGAGCAGCCGCCCCCGGCCCCGGC CCCGCGCCGGGAGCGCCGGGACCTGCCCGCCGAGCCGGCTGCAGCCCGAGGAGGAGGAGGAGGCGGCGGCGGAGGAGGAGGAGGACGGGG GCCCCAGGCGCGGGCGCGGGGAGGCGGCCCCGGAGAACCGCGGGGACAGCAGCCGGCCAGCCGGGGGGCACTGCCCGCCCGGGCTCTGGA TCCACACCCAAGTCCGCTCATCACCCTGGAGACTCAGGATGGCTACTTTTCTCATCGGCCGAAAGAGAAAGTGCGAACAGACAGCAACAA CGAGAACTCTGTCCCCAAAGACTTTGAGAATGTCGACAACAGCAACTTCGCACCCAGGACTCAAAAGCAGAAGCACCAGCCTGAGTTGGC GAAGAAGCCACCGAGTAGACAGAAGGAGCTTTTGAAAAGGAAGCTGGAACAGCAGGAGAAAGGAAAAGGACATACATTCCCTGGGAAAGG CCCCGGTGAGGTGCTGCCTCCCGGGGACAGAGCCGCAGCCAACAGCAGCCACGGGAAGGATGTGTCCAGACCGCCTCATGCCAGGAAAAC TGGGGGCAGCTCCCCCGAGACCAAGTATGACCAGCCCCCTAAGTGTGACATCTCAGGCAAGGAGGCCATCTCTGCCCTGTCCCGTGCTAA GTCCAAGCACTGCCGCCAGGAGATTGGGGAGACTTACTGCCGCCACAAGTTAGGGCTGCTGATGCCTGAGAAGGTGACTCGGTTCTGCCC CCTCGAGGGTAAAGCCAACAAGAACGTGCAGTGGGACGAGGACTCCGTGGAGTACATGCCAGCCAACCCGGTCAGAATCGCCTTTGTCCT GGTGGTCCACGGCCGTGCCTCTCGGCAGTTGCAGCGCATGTTCAAGGCCATCTACCACAAAGACCACTTCTACTACATCCACGTGGACAA GCGCTCTAATTACCTGCATCGGCAAGTGCTCCAGGTCTCCAGGCAGTACAGCAATGTCCGCGTCACCCCCTGGAGAATGGCCACCATCTG GGGAGGAGCCAGCCTCCTGTCCACCTACCTGCAGAGCATGCGGGACCTCCTGGAGATGACCGACTGGCCCTGGGACTTCTTCATCAACCT GAGTGCGGCCGACTACCCCATCAGGTGTGTGGACCAGAAGTTCCGGCGCTGCCCCCCACTGGCCACCACCAGCGTGATCATTGTGTTCCA CAACGAAGCCTGGTCCACACTGCTGCGAACAGTGTACAGCGTCCTACACACCACCCCTGCCATCTTGCTCAAGGAGATCATACTGGTGGA TGATGCCAGCACAGAGGAGCACCTAAAGGAGAAGCTGGAGCAGTACGTGAAGCAGCTGCAGGTGGTGAGGGTGGTGCGGCAGGAGGAGCG GAAGGGGCTGATCACCGCCCGGCTGCTGGGGGCCAGCGTGGCACAGGCGGAGGTGCTCACGTTCCTGGATGCCCACTGTGAGTGCTTCCA CGGCTGGCTGGAGCCCCTCCTGGCTCGAATCGCTGAGGACAAGACAGTGGTGGTGAGCCCAGACATCGTCACCATCGACCTTAATACTTT TGAGTTCGCCAAGCCCGTCCAGAGGGGCAGAGTCCATAGCCGAGGCAACTTTGACTGGAGCCTGACCTTCGGCTGGGAAACACTTCCTCC ACATGAGAAGCAGAGGCGCAAGGATGAAACCTACCCCATCAAATCCCCGACGTTTGCTGGTGGCCTCTTCTCCATCTCCAAGTCCTACTT TGAGCACATCGGTACCTATGATAATCAGATGGAGATCTGGGGAGGGGAGAACGTGGAAATGTCCTTCCGGGTGTGGCAGTGTGGGGGCCA GCTGGAGATCATCCCCTGCTCTGTCGTAGGCCATGTGTTCCGGACCAAGAGCCCCCACACCTTCCCCAAGGGCACTAGTGTCATTGCTCG CAATCAAGTGCGCCTGGCAGAGGTCTGGATGGACAGCTACAAGAAGATTTTCTATAGGAGAAATCTGCAGGCAGCAAAGATGGCCCAAGA GAAATCCTTCGGTGACATTTCGGAACGACTGCAGCTGAGGGAACAACTGCACTGTCACAACTTTTCCTGGTACCTGCACAATGTCTACCC AGAGATGTTTGTTCCTGACCTGACGCCCACCTTCTATGGTGCCATCAAGAACCTCGGCACCAACCAATGCCTGGATGTGGGTGAGAACAA CCGCGGGGGGAAGCCCCTCATCATGTACTCCTGCCACGGCCTTGGCGGCAACCAGTACTTTGAGTACACAACTCAGAGGGACCTTCGCCA CAACATCGCAAAGCAGCTGTGTCTACATGTCAGCAAGGGTGCTCTGGGCCTTGGGAGCTGTCACTTCACTGGCAAGAATAGCCAGGTCCC CAAGGACGAGGAATGGGAATTGGCCCAGGATCAGCTCATCAGGAACTCAGGATCTGGTACCTGCCTGACATCCCAGGACAAAAAGCCAGC CATGGCCCCCTGCAATCCCAGTGACCCCCATCAGTTGTGGCTCTTTGTCTAGGACCCAGATCATCCCCAGAGAGAGCCCCCACAAGCTCC TCAGGAAACAGGATTGCTGATGTCTGGGAACCTGATCACCAGCTTCTCTGGAGGCCGTAAAGATGGATTTCTAAACCCACTGGGTGGCAA GGCAGGACCTTCCTAATCCTTGCAACAACATTGGGCCCATTTTCTTTCCTTCACACCGATGGAAGAGACCATTAGGACATATATTTAGCC TAGCGTTTTCCTGTTCTAGAAATAGAGGCTCCCAAAGTAGGGAAGGCAGCTGGGGGAGGGTTCAGGGCAGCAATGCTGAGTTCAAGAAAA GTACTTCAGGCTGGGCACAGTGGCTCATGCCTGAAATCCTAGCACTTTGGGAAGACAATGTGGGAGAATGGCTTGAGCCCAGGAGTTCAA GACCGGCCTGAGCAACATAGTGAGGATCCCATCTCTACGCCCACCCTCCCCCCGGCAAAAAAAAAAAGCTGGGTATGGTGGCTTATGCCT GTAGTCGCAGCTACTCAGAAGGCTGAGGTGGGAGGATTGCTTGTTCCCCGGAGGTTGAAGCTACAGTGAGCCTTGATTGTGTCACTGCAC TCCAGCCTGGGCAACAGGTAAGACTCTGTCTCAAAAAAAAACAAAAAAGAAGAAGAAAAGTACTTCTACAGCCATGTCCTATTCCTTGAT CATCCAAAGCACCTGCAGAGTCCAGTGAAATGATATATTCTGGCTGGGCACAGTGGCTCACACCTGTAATCCTAGCACTTTGGGAGGCCA AGGCAGGTGGATCACCTGAGGTCAGAAGTTTGAAACCAGCCTGGACTACATGGTGAAACTCCATCTCTACTAAAAGTACAAAAATTAGCT GGGCATGATGGCACGCACCTGCAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTCGAACCCAGGAGGCAGAGGTTGCAGTGAG CCAAGACAGCACCATTGCACCCCAGCCTGAGCAACAAGAGCGAAACTCCATCTCAGGAAAAAAAAAAAAAAAAAAAGTATATTCTAACAG ACAGATCAGAGGTCTAAGAGATCCTCCCTTGCTATTATTACCTGAAGTCTGTAGAACTGTTTACAGATATCTCCTTGACAGGTGTCCTTT ATCTTACTTTATCTGTACAGTAATCCTGTGAGAAAGACAGGACAGAAACCACTGTGCCTATTTTACAGATACGAAAACTGAGACACAGGT AAAGGGGCTTGTCTGTAGTCCCATAGCTAGCAGATGGCTGGAGCCAAGACTGAGGCTCGTTCTTCAATGCTGAGCCAGGGCTCCTTCCGC TGCACCACAAGAACGCTAGACCACTCGCCACCAGCCTTCTCATTCCCTCTTCCTCCATTCTAATCATTTCTAGCTGGCTGGCCTCCACAG AGCATAGGAAAACAGCCAGGGCCGGGCACGGTGGCTCATGCCTGTAATCTCAACACTCTGGGAGGCCGAGCCGGGTGGATAACCTGAGGT CAGGAATTCGAGACCAGCCTGGCCAACATGGTAAAACCCCATCTCTACTAAAAATATAAAAATTAGCCAGGCATGGTGGCGCACACCTGT AATCCCAGCTACTCAAGAGGCTGAGGCAGGAGAATTGCTTAAATCTGGGAGGCGGAAGTTGCAGTGAGCCAAGATCGCGCCACTGAACTC CAGCCTAGGCAACAAGAGCAAAACTCCATCTCCAAAAAAAAGAAAGGAAAAACAGGGCCAGGTAGCCATTGTGGAGAGAGCACACTTAGG AATCCTGGGATGTTAGTGTTAAAAGAAAGCTCCTGGAGCCAGTGATTCTCAGGTTTGTCCCAGAACCCTTTTTTCTAAGCCCCATATAAA AGGTAGATTAAAAAAACAAAGTAGCATGAGTGAAATTGAGAGAGGGACAGGTAATGCCTTCCAGCCCCTAACTTCTAACAATCTGGAAGC ACAACGTGAAAATCACGTAGCCCAACCCTATCATTTTCATATTATGAAACTGAGTCCAGGTAAGTGAATCTGTCCAAGGTCACCCAGCAA GGTATCAGTAGCCCTGAGGGTAAGGACTCTGATAAGGCTCGGGAGGGTCCTGGAAAGCCTGAGGCGGCAGGAAGAGTGTGCAGAGTTGAG CGTGTCTGGAAGGCTGATCCACTGCTGGGCCCACATCAAAGCCCCCATGGGGAGCAGACCCGACTGCACATGGCTCTTTTGCTGGAAGAA GAGCATGGCTGCGCAGAGGACTAAAATTTCATCTGGGAAGGCTTCTTTTGACTGTCAGTAGCAGGATGTCACCAGATGAGGGTGCTATGG GACCACAGCTGTCTTTGTTCCCATTGCAACTCAACCCTGCGGGAGGCCGCCTACATCCCTGAGAGCCTTCTGGAGCCTACAGAGGAGACA TTGGCCAGCCAAAAGGAAAGGAGTGGCCAGGGTACGACCTGGAGTAGGGAAGGGAAAAAGTTCCCGGAAAGAAGAGAATTGGATGAGAGG TCTCAGTGGAAATAAAGGTTTTCTGGCATTGGTCAAGGAAACTCGCGTTGTGTTCTCTTACCTGTGTTGTCCCTTAGCTGAATCAGTTGA TTTGGGCTATGAAGAACCACACACATCTGAAAAGTTCTGTTACAGCCACTGTCTCATGTCCCCAAACATTCTCTGGCCCTAAATCTAGCT TATGTATTGTGTCAAGCACGTGGAGACGTGAGACGTCAAACGAGGTCCTGTCCCCGTGGAACTCACACGCTAAATGTAAGCAAATCATAG CAAGCCTGGAGATGCTCCAAGAGGTGCTGGATGAGTTAGAAGGAGCAATTCCTTCCACTTAGGGAATCAGATAAGGCCTCACAAAGATGG CAATGTTTGACCTAAGACCTCGGAAGATGAGTCCTCAGATGGGAAGGGCTCAATAAGCAGAGTTGTTACACAGGCAGCAGCCTGGCAGGA GCAAAGCCACAGAGGACATGTGGCCCCAGTGGGTCTGAGAAACCCAGAGGACATTGGGGTGAGGGAGTGACTGGTGTAGAAGCTGGAAGA TCAGAGTTACATCATGAATTTCAGGGGCCCTAGGCACTTTAGCCTTCACGGAGCTCTTGCTCCATTCAAAAAAAAATTAATGTTATGACT >In-frame_XYLT1_ENST00000261381_chr16_17292069_-_GALNT6_ENST00000356317_chr12_51771151_-_3378nt GCGGCCGCGGGAGCTGCGGGGAGCGCGGGGGCGGCCCGGAGCGTGCCGGGGTCCCCGCGCCTCGCTCGCCGGCCGCGCTCCGAAGATGGT GGCGGCGCCGTGCGCCCGGAGGCTGGCCCGGCGCTCGCACTCGGCGCTGCTCGCGGCGCTCACGGTGCTGCTGCTGCAGACGCTGGTCGT GTGGAATTTCAGCAGCCTCGACTCCGGGGCCGGGGAGCGCCGCGGGGGCGCAGCGGTCGGCGGCGGGGAGCAGCCGCCCCCGGCCCCGGC CCCGCGCCGGGAGCGCCGGGACCTGCCCGCCGAGCCGGCTGCAGCCCGAGGAGGAGGAGGAGGCGGCGGCGGAGGAGGAGGAGGACGGGG GCCCCAGGCGCGGGCGCGGGGAGGCGGCCCCGGAGAACCGCGGGGACAGCAGCCGGCCAGCCGGGGGGCACTGCCCGCCCGGGCTCTGGA TCCACACCCAAGTCCGCTCATCACCCTGGAGACTCAGGATGGCTACTTTTCTCATCGGCCGAAAGAGAAAGTGCGAACAGACAGCAACAA CGAGAACTCTGTCCCCAAAGACTTTGAGAATGTCGACAACAGCAACTTCGCACCCAGGACTCAAAAGCAGAAGCACCAGCCTGAGTTGGC GAAGAAGCCACCGAGTAGACAGAAGGAGCTTTTGAAAAGGAAGCTGGAACAGCAGGAGAAAGGAAAAGGACATACATTCCCTGGGAAAGG CCCCGGTGAGGTGCTGCCTCCCGGGGACAGAGCCGCAGCCAACAGCAGCCACGGGAAGGATGTGTCCAGACCGCCTCATGCCAGGAAAAC TGGGGGCAGCTCCCCCGAGACCAAGTATGACCAGCCCCCTAAGTGTGACATCTCAGGCAAGGAGGCCATCTCTGCCCTGTCCCGTGCTAA GTCCAAGCACTGCCGCCAGGAGATTGGGGAGACTTACTGCCGCCACAAGTTAGGGCTGCTGATGCCTGAGAAGGTGACTCGGTTCTGCCC CCTCGAGGGTAAAGCCAACAAGAACGTGCAGTGGGACGAGGACTCCGTGGAGTACATGCCAGCCAACCCGGTCAGAATCGCCTTTGTCCT GGTGGTCCACGGCCGTGCCTCTCGGCAGTTGCAGCGCATGTTCAAGGCCATCTACCACAAAGACCACTTCTACTACATCCACGTGGACAA GCGCTCTAATTACCTGCATCGGCAAGTGCTCCAGGTCTCCAGGCAGTACAGCAATGTCCGCGTCACCCCCTGGAGAATGGCCACCATCTG GGGAGGAGCCAGCCTCCTGTCCACCTACCTGCAGAGCATGCGGGACCTCCTGGAGATGACCGACTGGCCCTGGGACTTCTTCATCAACCT GAGTGCGGCCGACTACCCCATCAGGTGTGTGGACCAGAAGTTCCGGCGCTGCCCCCCACTGGCCACCACCAGCGTGATCATTGTGTTCCA CAACGAAGCCTGGTCCACACTGCTGCGAACAGTGTACAGCGTCCTACACACCACCCCTGCCATCTTGCTCAAGGAGATCATACTGGTGGA TGATGCCAGCACAGAGGAGCACCTAAAGGAGAAGCTGGAGCAGTACGTGAAGCAGCTGCAGGTGGTGAGGGTGGTGCGGCAGGAGGAGCG GAAGGGGCTGATCACCGCCCGGCTGCTGGGGGCCAGCGTGGCACAGGCGGAGGTGCTCACGTTCCTGGATGCCCACTGTGAGTGCTTCCA CGGCTGGCTGGAGCCCCTCCTGGCTCGAATCGCTGAGGACAAGACAGTGGTGGTGAGCCCAGACATCGTCACCATCGACCTTAATACTTT TGAGTTCGCCAAGCCCGTCCAGAGGGGCAGAGTCCATAGCCGAGGCAACTTTGACTGGAGCCTGACCTTCGGCTGGGAAACACTTCCTCC ACATGAGAAGCAGAGGCGCAAGGATGAAACCTACCCCATCAAATCCCCGACGTTTGCTGGTGGCCTCTTCTCCATCTCCAAGTCCTACTT TGAGCACATCGGTACCTATGATAATCAGATGGAGATCTGGGGAGGGGAGAACGTGGAAATGTCCTTCCGGGTGTGGCAGTGTGGGGGCCA GCTGGAGATCATCCCCTGCTCTGTCGTAGGCCATGTGTTCCGGACCAAGAGCCCCCACACCTTCCCCAAGGGCACTAGTGTCATTGCTCG CAATCAAGTGCGCCTGGCAGAGGTCTGGATGGACAGCTACAAGAAGATTTTCTATAGGAGAAATCTGCAGGCAGCAAAGATGGCCCAAGA GAAATCCTTCGGTGACATTTCGGAACGACTGCAGCTGAGGGAACAACTGCACTGTCACAACTTTTCCTGGTACCTGCACAATGTCTACCC AGAGATGTTTGTTCCTGACCTGACGCCCACCTTCTATGGTGCCATCAAGAACCTCGGCACCAACCAATGCCTGGATGTGGGTGAGAACAA CCGCGGGGGGAAGCCCCTCATCATGTACTCCTGCCACGGCCTTGGCGGCAACCAGTACTTTGAGTACACAACTCAGAGGGACCTTCGCCA CAACATCGCAAAGCAGCTGTGTCTACATGTCAGCAAGGGTGCTCTGGGCCTTGGGAGCTGTCACTTCACTGGCAAGAATAGCCAGGTCCC CAAGGACGAGGAATGGGAATTGGCCCAGGATCAGCTCATCAGGAACTCAGGATCTGGTACCTGCCTGACATCCCAGGACAAAAAGCCAGC CATGGCCCCCTGCAATCCCAGTGACCCCCATCAGTTGTGGCTCTTTGTCTAGGACCCAGATCATCCCCAGAGAGAGCCCCCACAAGCTCC TCAGGAAACAGGATTGCTGATGTCTGGGAACCTGATCACCAGCTTCTCTGGAGGCCGTAAAGATGGATTTCTAAACCCACTGGGTGGCAA GGCAGGACCTTCCTAATCCTTGCAACAACATTGGGCCCATTTTCTTTCCTTCACACCGATGGAAGAGACCATTAGGACATATATTTAGCC TAGCGTTTTCCTGTTCTAGAAATAGAGGCTCCCAAAGTAGGGAAGGCAGCTGGGGGAGGGTTCAGGGCAGCAATGCTGAGTTCAAGAAAA GTACTTCAGGCTGGGCACAGTGGCTCATGCCTGAAATCCTAGCACTTTGGGAAGACAATGTGGGAGAATGGCTTGAGCCCAGGAGTTCAA GACCGGCCTGAGCAACATAGTGAGGATCCCATCTCTACGCCCACCCTCCCCCCGGCAAAAAAAAAAAGCTGGGTATGGTGGCTTATGCCT GTAGTCGCAGCTACTCAGAAGGCTGAGGTGGGAGGATTGCTTGTTCCCCGGAGGTTGAAGCTACAGTGAGCCTTGATTGTGTCACTGCAC |
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FusionGenePPI for XYLT1_GALNT6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| XYLT1 | MYC, ADH1C, MEF2A | GALNT6 | TMEM9, TAF9, ALDOA, SLC5A6, NDUFAF6, ATP2B3, ASPHD2, NDUFB6, SLC30A1, NDUFB8, ATP2B2, NDUFA12, EDEM1, NDUFS6, GAS6, FAM20B, B4GALT3, NDUFB5, NDUFS4, RMND1, SLC9A1, SLC39A10, PLXNA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for XYLT1_GALNT6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for XYLT1_GALNT6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | XYLT1 | C4014294 | DESBUQUOIS DYSPLASIA 2 | 2 | UNIPROT |
| Hgene | XYLT1 | C0033847 | Pseudoxanthoma Elasticum | 1 | CTD_human;UNIPROT |
| Hgene | XYLT1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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