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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42250

FusionGeneSummary for XXYLT1_FARP1

check button Fusion gene summary
Fusion gene informationFusion gene name: XXYLT1_FARP1
Fusion gene ID: 42250
HgeneTgene
Gene symbol

XXYLT1

FARP1

Gene ID

152002

10160

Gene namexyloside xylosyltransferase 1FERM, ARH/RhoGEF and pleckstrin domain protein 1
SynonymsC3orf21CDEP|FARP1-IT1|PLEKHC2|PPP1R75
Cytomap

3q29

13q32.2

Type of geneprotein-codingprotein-coding
Descriptionxyloside xylosyltransferase 1UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferaseFERM, ARHGEF and pleckstrin domain-containing protein 1FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)FERM, RhoGEF and pleckstrin domain-containing protein 1PH domain-containing family C member 2chondrocyte-derived ezrin-li
Modification date2018051920180519
UniProtAcc

Q8NBI6

Q9Y4F1

Ensembl transtripts involved in fusion geneENST00000310380, ENST00000437101, 
ENST00000429994, ENST00000355729, 
ENST00000460582, ENST00000356740, 
ENST00000595437, ENST00000376586, 
ENST00000319562, ENST00000376581, 
ENST00000593990, 
Fusion gene scores* DoF score8 X 5 X 6=2409 X 10 X 5=450
# samples 910
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XXYLT1 [Title/Abstract] AND FARP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXXYLT1

GO:0016266

O-glycan processing

8982869|22117070

TgeneFARP1

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK024181XXYLT1chr3

194927613

-FARP1chr13

98879492

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000310380ENST00000595437XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000310380ENST00000376586XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000310380ENST00000319562XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000310380ENST00000376581XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000310380ENST00000593990XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000437101ENST00000595437XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000437101ENST00000376586XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000437101ENST00000319562XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000437101ENST00000376581XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000437101ENST00000593990XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000429994ENST00000595437XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000429994ENST00000376586XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000429994ENST00000319562XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000429994ENST00000376581XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000429994ENST00000593990XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000355729ENST00000595437XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000355729ENST00000376586XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000355729ENST00000319562XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000355729ENST00000376581XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000355729ENST00000593990XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000460582ENST00000595437XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000460582ENST00000376586XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000460582ENST00000319562XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000460582ENST00000376581XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000460582ENST00000593990XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000356740ENST00000595437XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000356740ENST00000376586XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000356740ENST00000319562XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000356740ENST00000376581XXYLT1chr3

194927613

-FARP1chr13

98879492

+
intron-intronENST00000356740ENST00000593990XXYLT1chr3

194927613

-FARP1chr13

98879492

+

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FusionProtFeatures for XXYLT1_FARP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XXYLT1

Q8NBI6

FARP1

Q9Y4F1

Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats inthe extracellular domain of target proteins by catalyzing theaddition of the second xylose (PubMed:22117070, PubMed:8982869).Known targets include Notch proteins and coagulation factors, suchas F9 (PubMed:22117070, PubMed:8982869).{ECO:0000269|PubMed:22117070, ECO:0000269|PubMed:8982869}. Functions as guanine nucleotide exchange factor forRAC1. May play a role in semaphorin signaling. Plays a role in theassembly and disassembly of dendritic filopodia, the formation ofdendritic spines, regulation of dendrite length and ultimately theformation of synapses (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for XXYLT1_FARP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for XXYLT1_FARP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for XXYLT1_FARP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for XXYLT1_FARP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFARP1C0236969Substance-Related Disorders1CTD_human