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Fusion gene ID: 42238 |
FusionGeneSummary for XRN2_RIN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: XRN2_RIN2 | Fusion gene ID: 42238 | Hgene | Tgene | Gene symbol | XRN2 | RIN2 | Gene ID | 22803 | 54453 |
| Gene name | 5'-3' exoribonuclease 2 | Ras and Rab interactor 2 | |
| Synonyms | - | MACS|RASSF4 | |
| Cytomap | 20p11.22 | 20p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 5'-3' exoribonuclease 2DHP proteinDhm1-like protein | ras and Rab interactor 2RAB5 interacting protein 2RAS association (RalGDS/AF-6) domain containing protein JC265RAS association domain family 4RAS inhibitor JC265RAS interaction/interference protein 2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9H0D6 | Q8WYP3 | |
| Ensembl transtripts involved in fusion gene | ENST00000377191, ENST00000430571, ENST00000539513, | ENST00000255006, ENST00000440354, ENST00000484638, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 5 X 5 X 5=125 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: XRN2 [Title/Abstract] AND RIN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | XRN2 | GO:0000738 | DNA catabolic process, exonucleolytic | 15565158 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A6B8-01A | XRN2 | chr20 | 21284111 | + | RIN2 | chr20 | 19915743 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000377191 | ENST00000255006 | XRN2 | chr20 | 21284111 | + | RIN2 | chr20 | 19915743 | + |
| In-frame | ENST00000377191 | ENST00000440354 | XRN2 | chr20 | 21284111 | + | RIN2 | chr20 | 19915743 | + |
| 5CDS-intron | ENST00000377191 | ENST00000484638 | XRN2 | chr20 | 21284111 | + | RIN2 | chr20 | 19915743 | + |
| 5UTR-3CDS | ENST00000430571 | ENST00000255006 | XRN2 | chr20 | 21284111 | + | RIN2 | chr20 | 19915743 | + |
| 5UTR-3CDS | ENST00000430571 | ENST00000440354 | XRN2 | chr20 | 21284111 | + | RIN2 | chr20 | 19915743 | + |
| 5UTR-intron | ENST00000430571 | ENST00000484638 | XRN2 | chr20 | 21284111 | + | RIN2 | chr20 | 19915743 | + |
| intron-3CDS | ENST00000539513 | ENST00000255006 | XRN2 | chr20 | 21284111 | + | RIN2 | chr20 | 19915743 | + |
| intron-3CDS | ENST00000539513 | ENST00000440354 | XRN2 | chr20 | 21284111 | + | RIN2 | chr20 | 19915743 | + |
| intron-intron | ENST00000539513 | ENST00000484638 | XRN2 | chr20 | 21284111 | + | RIN2 | chr20 | 19915743 | + |
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FusionProtFeatures for XRN2_RIN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| XRN2 | RIN2 |
| Possesses 5'->3' exoribonuclease activity (Bysimilarity). May promote the termination of transcription by RNApolymerase II. During transcription termination, cleavage at thepolyadenylation site liberates a 5' fragment which is subsequentlyprocessed to form the mature mRNA and a 3' fragment which remainsattached to the elongating polymerase. The processive degradationof this 3' fragment by this protein may promote termination oftranscription. Binds to RNA polymerase II (RNAp II) transcriptiontermination R-loops formed by G-rich pause sites(PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158,ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}. | Ras effector protein. May function as an upstreamactivator and/or downstream effector for RAB5B in endocyticpathway. May function as a guanine nucleotide exchange (GEF) ofRAB5B, required for activating the RAB5 proteins by exchangingbound GDP for free GTP. {ECO:0000269|PubMed:11733506}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >RIN2 | chr20:21284111 | chr20:19915743 | ENST00000255006 | + | 1 | 12 | 307_314 | 68 | 945 | Compositional bias | Note=Poly-Pro |
| Tgene | >RIN2 | chr20:21284111 | chr20:19915743 | ENST00000255006 | + | 1 | 12 | 618_757 | 68 | 945 | Domain | VPS9 |
| Tgene | >RIN2 | chr20:21284111 | chr20:19915743 | ENST00000255006 | + | 1 | 12 | 787_878 | 68 | 945 | Domain | Ras-associating |
| Tgene | >RIN2 | chr20:21284111 | chr20:19915743 | ENST00000255006 | + | 1 | 12 | 97_190 | 68 | 945 | Domain | SH2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >XRN2 | chr20:21284111 | chr20:19915743 | ENST00000377191 | + | 1 | 30 | 262_278 | 25 | 951 | Zinc finger | Note=CCHC-type |
| Hgene | >XRN2 | chr20:21284111 | chr20:19915743 | ENST00000430571 | + | 1 | 29 | 262_278 | -9 | 875 | Zinc finger | Note=CCHC-type |
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FusionGeneSequence for XRN2_RIN2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_XRN2_ENST00000377191_chr20_21284111_+_RIN2_ENST00000255006_chr20_19915743_+_902aa MGVPAFFRWLSRKYPSIIVNCVEEKLIDTIASEIGELKQEMVRTDVNLENGLEPAETHSMVRHKDGGYSEEEDVKTCARDSGYDSLSNRL SILDRLLHTHPIWLQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPLKEFAIKESTYTFSLEGSGISFADLFRLIAF YCISRDVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPADSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELECSQ TNGALCFINPLFLKVHSQDLSGGLKRPSTRTPNANGTERTRSPPPRPPPPAINSLHTSPRLARTETQTSMPETVNHNKHGNVALPGTKPT PIPPPRLKKQASFLEAEGGAKTLSGGRPGAGPELELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSISTSSSDSLEF DRSMPLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFMTPEKRMVRRIAELSRDKCTYFGCLVQ DYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYLSQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQL KENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLEL DTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTG KTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTT >In-frame_XRN2_ENST00000377191_chr20_21284111_+_RIN2_ENST00000440354_chr20_19915743_+_469aa MGVPAFFRWLSRKYPSIIVNCVEEKLIDTIASEIGELKQEMVRTDVNLENGLEPAETHSMVRHKDGGYSEEEDVKTCARDSGYDSLSNRL SILDRLLHTHPIWLQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPLKEFAIKESTYNVVLEKAMHKCILKPLKGHV EAMLKDFHMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADD FLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSETRDTLRQWHKRRTTNRTIPSVDDF QNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_XRN2_ENST00000377191_chr20_21284111_+_RIN2_ENST00000255006_chr20_19915743_+_2706nt ATGGGAGTCCCGGCGTTCTTCCGCTGGCTCAGCCGCAAGTACCCGTCCATCATAGTCAACTGCGTGGAAGAGAAGCTCATTGACACAATT GCCTCGGAGATCGGAGAACTGAAACAGGAGATGGTGCGGACAGATGTCAACCTGGAAAATGGCCTGGAACCCGCTGAAACCCACAGCATG GTAAGACACAAGGATGGTGGCTATTCCGAGGAAGAGGACGTGAAGACCTGTGCCCGGGACTCAGGCTATGACAGCCTCTCCAACAGGCTC AGCATCTTGGACCGGCTCCTCCACACCCACCCCATATGGCTGCAGCTGAGTCTGAGTGAGGAGGAGGCAGCAGAGGTCCTGCAGGCCCAG CCTCCGGGGATCTTCCTGGTTCATAAATCTACCAAGATGCAGAAGAAAGTCCTCTCCCTCCGCCTGCCCTGTGAATTTGGGGCCCCACTC AAGGAATTTGCCATAAAGGAAAGCACATACACCTTTTCCCTGGAAGGCTCAGGAATCAGTTTCGCAGATTTATTCCGGCTCATTGCTTTC TACTGCATCAGCAGGGATGTTCTACCATTTACCTTGAAGTTGCCTTATGCCATTTCAACAGCCAAGTCGGAGGCTCAGCTTGAAGAACTG GCCCAGATGGGACTAAATTTCTGGAGCTCCCCAGCTGACAGCAAACCCCCGAACCTTCCACCTCCCCATAGGCCTCTTTCCTCCGACGGT GTCTGTCCTGCCTCCCTGCGTCAGCTCTGCCTTATAAATGGAGTGCATTCTATCAAAACCAGGACGCCTTCAGAGCTGGAGTGCAGCCAG ACCAACGGGGCCCTGTGCTTTATTAATCCCCTTTTCTTGAAAGTGCACAGCCAGGACCTCAGTGGAGGCCTGAAACGGCCGAGCACAAGG ACTCCCAACGCGAATGGCACGGAGCGGACTCGGTCCCCCCCACCCAGGCCCCCGCCACCCGCTATTAATAGTCTCCACACAAGCCCTCGG CTGGCCAGGACTGAAACCCAGACGAGCATGCCAGAAACAGTCAACCATAACAAACATGGGAACGTAGCTCTGCCTGGAACGAAACCAACT CCCATCCCTCCACCCCGGCTGAAGAAGCAGGCTTCTTTTCTGGAAGCAGAGGGCGGTGCAAAGACCTTGAGCGGCGGCCGGCCGGGCGCA GGCCCGGAGCTGGAGCTGGGCACAGCTGGCAGCCCAGGTGGGGCCCCGCCTGAGGCCGCCCCGGGGGATTGCACAAGGGCCCCGCCGCCC AGCTCTGAATCACGGCCCCCGTGCCATGGAGGCCGGCAGCGGCTGAGCGACATGAGCATTTCTACTTCCTCCTCCGACTCGCTGGAGTTC GACCGGAGCATGCCTCTGTTTGGCTACGAGGCGGACACCAACAGCAGCCTGGAGGACTACGAGGGGGAAAGTGACCAAGAGACCATGGCG CCCCCCATCAAGTCCAAAAAGAAAAGGAGCAGCTCCTTCGTGCTGCCCAAGCTCGTCAAGTCCCAGCTGCAGAAGGTGAGCGGGGTGTTC AGCTCCTTCATGACCCCGGAGAAGCGGATGGTCCGCAGGATCGCCGAGCTTTCCCGGGACAAATGCACCTACTTCGGGTGCTTAGTGCAG GACTACGTGAGCTTCCTGCAGGAGAACAAGGAGTGCCACGTGTCCAGCACCGACATGCTGCAGACCATCCGGCAGTTCATGACCCAGGTC AAGAACTATTTGTCTCAGAGCTCGGAGCTGGACCCCCCCATCGAGTCGCTGATCCCTGAAGACCAAATAGATGTGGTGCTGGAAAAAGCC ATGCACAAGTGCATCTTGAAGCCCCTCAAGGGGCACGTGGAGGCCATGCTGAAGGACTTTCACATGGCCGATGGCTCATGGAAGCAACTC AAGGAGAACCTGCAGCTTGTGCGGCAGAGGAATCCGCAGGAGCTGGGGGTCTTCGCCCCGACCCCTGATTTTGTGGATGTGGAGAAAATC AAAGTCAAGTTCATGACCATGCAGAAGATGTATTCGCCGGAAAAGAAGGTCATGCTGCTGCTGCGGGTCTGCAAGCTCATTTACACGGTC ATGGAGAACAACTCAGGGAGGATGTATGGCGCTGATGACTTCTTGCCAGTCCTGACCTATGTCATAGCCCAGTGTGACATGCTTGAATTG GACACTGAAATCGAGTACATGATGGAGCTCCTAGACCCATCGCTGTTACATGGAGAAGGAGGCTATTACTTGACAAGCGCATATGGAGCA CTTTCTCTGATAAAGAATTTCCAAGAAGAACAAGCAGCGCGACTGCTCAGCTCAGAAACCAGAGACACCCTGAGGCAGTGGCACAAACGG AGAACCACCAACCGGACCATCCCCTCTGTGGACGACTTCCAGAATTACCTCCGAGTTGCATTTCAGGAGGTCAACAGTGGTTGCACAGGA AAGACCCTCCTTGTGAGACCTTACATCACCACTGAGGATGTGTGTCAGATCTGCGCTGAGAAGTTCAAGGTGGGGGACCCTGAGGAGTAC AGCCTCTTTCTCTTCGTTGACGAGACATGGCAGCAGCTGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCA CAGCCCCACATCTTCCACTTTGTCTACAAACGCATCAAGAACGATCCTTATGGCATCATTTTCCAGAACGGGGAAGAAGACCTCACCACC >In-frame_XRN2_ENST00000377191_chr20_21284111_+_RIN2_ENST00000440354_chr20_19915743_+_1407nt ATGGGAGTCCCGGCGTTCTTCCGCTGGCTCAGCCGCAAGTACCCGTCCATCATAGTCAACTGCGTGGAAGAGAAGCTCATTGACACAATT GCCTCGGAGATCGGAGAACTGAAACAGGAGATGGTGCGGACAGATGTCAACCTGGAAAATGGCCTGGAACCCGCTGAAACCCACAGCATG GTAAGACACAAGGATGGTGGCTATTCCGAGGAAGAGGACGTGAAGACCTGTGCCCGGGACTCAGGCTATGACAGCCTCTCCAACAGGCTC AGCATCTTGGACCGGCTCCTCCACACCCACCCCATATGGCTGCAGCTGAGTCTGAGTGAGGAGGAGGCAGCAGAGGTCCTGCAGGCCCAG CCTCCGGGGATCTTCCTGGTTCATAAATCTACCAAGATGCAGAAGAAAGTCCTCTCCCTCCGCCTGCCCTGTGAATTTGGGGCCCCACTC AAGGAATTTGCCATAAAGGAAAGCACATACAATGTGGTGCTGGAAAAAGCCATGCACAAGTGCATCTTGAAGCCCCTCAAGGGGCACGTG GAGGCCATGCTGAAGGACTTTCACATGGCCGATGGCTCATGGAAGCAACTCAAGGAGAACCTGCAGCTTGTGCGGCAGAGGAATCCGCAG GAGCTGGGGGTCTTCGCCCCGACCCCTGATTTTGTGGATGTGGAGAAAATCAAAGTCAAGTTCATGACCATGCAGAAGATGTATTCGCCG GAAAAGAAGGTCATGCTGCTGCTGCGGGTCTGCAAGCTCATTTACACGGTCATGGAGAACAACTCAGGGAGGATGTATGGCGCTGATGAC TTCTTGCCAGTCCTGACCTATGTCATAGCCCAGTGTGACATGCTTGAATTGGACACTGAAATCGAGTACATGATGGAGCTCCTAGACCCA TCGCTGTTACATGGAGAAGGAGGCTATTACTTGACAAGCGCATATGGAGCACTTTCTCTGATAAAGAATTTCCAAGAAGAACAAGCAGCG CGACTGCTCAGCTCAGAAACCAGAGACACCCTGAGGCAGTGGCACAAACGGAGAACCACCAACCGGACCATCCCCTCTGTGGACGACTTC CAGAATTACCTCCGAGTTGCATTTCAGGAGGTCAACAGTGGTTGCACAGGAAAGACCCTCCTTGTGAGACCTTACATCACCACTGAGGAT GTGTGTCAGATCTGCGCTGAGAAGTTCAAGGTGGGGGACCCTGAGGAGTACAGCCTCTTTCTCTTCGTTGACGAGACATGGCAGCAGCTG GCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCACAGCCCCACATCTTCCACTTTGTCTACAAACGCATCAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_XRN2_ENST00000377191_chr20_21284111_+_RIN2_ENST00000255006_chr20_19915743_+_4322nt ACGTGGGAGGAAGTGCTGGTGCCCTCTGCCGCTGCTCCCGTCTCTTTGGTTACGCTCGTCAGCCGGTCGGCCGCCGCCTCCAGCCGTGTG CCGCTATGGGAGTCCCGGCGTTCTTCCGCTGGCTCAGCCGCAAGTACCCGTCCATCATAGTCAACTGCGTGGAAGAGAAGCTCATTGACA CAATTGCCTCGGAGATCGGAGAACTGAAACAGGAGATGGTGCGGACAGATGTCAACCTGGAAAATGGCCTGGAACCCGCTGAAACCCACA GCATGGTAAGACACAAGGATGGTGGCTATTCCGAGGAAGAGGACGTGAAGACCTGTGCCCGGGACTCAGGCTATGACAGCCTCTCCAACA GGCTCAGCATCTTGGACCGGCTCCTCCACACCCACCCCATATGGCTGCAGCTGAGTCTGAGTGAGGAGGAGGCAGCAGAGGTCCTGCAGG CCCAGCCTCCGGGGATCTTCCTGGTTCATAAATCTACCAAGATGCAGAAGAAAGTCCTCTCCCTCCGCCTGCCCTGTGAATTTGGGGCCC CACTCAAGGAATTTGCCATAAAGGAAAGCACATACACCTTTTCCCTGGAAGGCTCAGGAATCAGTTTCGCAGATTTATTCCGGCTCATTG CTTTCTACTGCATCAGCAGGGATGTTCTACCATTTACCTTGAAGTTGCCTTATGCCATTTCAACAGCCAAGTCGGAGGCTCAGCTTGAAG AACTGGCCCAGATGGGACTAAATTTCTGGAGCTCCCCAGCTGACAGCAAACCCCCGAACCTTCCACCTCCCCATAGGCCTCTTTCCTCCG ACGGTGTCTGTCCTGCCTCCCTGCGTCAGCTCTGCCTTATAAATGGAGTGCATTCTATCAAAACCAGGACGCCTTCAGAGCTGGAGTGCA GCCAGACCAACGGGGCCCTGTGCTTTATTAATCCCCTTTTCTTGAAAGTGCACAGCCAGGACCTCAGTGGAGGCCTGAAACGGCCGAGCA CAAGGACTCCCAACGCGAATGGCACGGAGCGGACTCGGTCCCCCCCACCCAGGCCCCCGCCACCCGCTATTAATAGTCTCCACACAAGCC CTCGGCTGGCCAGGACTGAAACCCAGACGAGCATGCCAGAAACAGTCAACCATAACAAACATGGGAACGTAGCTCTGCCTGGAACGAAAC CAACTCCCATCCCTCCACCCCGGCTGAAGAAGCAGGCTTCTTTTCTGGAAGCAGAGGGCGGTGCAAAGACCTTGAGCGGCGGCCGGCCGG GCGCAGGCCCGGAGCTGGAGCTGGGCACAGCTGGCAGCCCAGGTGGGGCCCCGCCTGAGGCCGCCCCGGGGGATTGCACAAGGGCCCCGC CGCCCAGCTCTGAATCACGGCCCCCGTGCCATGGAGGCCGGCAGCGGCTGAGCGACATGAGCATTTCTACTTCCTCCTCCGACTCGCTGG AGTTCGACCGGAGCATGCCTCTGTTTGGCTACGAGGCGGACACCAACAGCAGCCTGGAGGACTACGAGGGGGAAAGTGACCAAGAGACCA TGGCGCCCCCCATCAAGTCCAAAAAGAAAAGGAGCAGCTCCTTCGTGCTGCCCAAGCTCGTCAAGTCCCAGCTGCAGAAGGTGAGCGGGG TGTTCAGCTCCTTCATGACCCCGGAGAAGCGGATGGTCCGCAGGATCGCCGAGCTTTCCCGGGACAAATGCACCTACTTCGGGTGCTTAG TGCAGGACTACGTGAGCTTCCTGCAGGAGAACAAGGAGTGCCACGTGTCCAGCACCGACATGCTGCAGACCATCCGGCAGTTCATGACCC AGGTCAAGAACTATTTGTCTCAGAGCTCGGAGCTGGACCCCCCCATCGAGTCGCTGATCCCTGAAGACCAAATAGATGTGGTGCTGGAAA AAGCCATGCACAAGTGCATCTTGAAGCCCCTCAAGGGGCACGTGGAGGCCATGCTGAAGGACTTTCACATGGCCGATGGCTCATGGAAGC AACTCAAGGAGAACCTGCAGCTTGTGCGGCAGAGGAATCCGCAGGAGCTGGGGGTCTTCGCCCCGACCCCTGATTTTGTGGATGTGGAGA AAATCAAAGTCAAGTTCATGACCATGCAGAAGATGTATTCGCCGGAAAAGAAGGTCATGCTGCTGCTGCGGGTCTGCAAGCTCATTTACA CGGTCATGGAGAACAACTCAGGGAGGATGTATGGCGCTGATGACTTCTTGCCAGTCCTGACCTATGTCATAGCCCAGTGTGACATGCTTG AATTGGACACTGAAATCGAGTACATGATGGAGCTCCTAGACCCATCGCTGTTACATGGAGAAGGAGGCTATTACTTGACAAGCGCATATG GAGCACTTTCTCTGATAAAGAATTTCCAAGAAGAACAAGCAGCGCGACTGCTCAGCTCAGAAACCAGAGACACCCTGAGGCAGTGGCACA AACGGAGAACCACCAACCGGACCATCCCCTCTGTGGACGACTTCCAGAATTACCTCCGAGTTGCATTTCAGGAGGTCAACAGTGGTTGCA CAGGAAAGACCCTCCTTGTGAGACCTTACATCACCACTGAGGATGTGTGTCAGATCTGCGCTGAGAAGTTCAAGGTGGGGGACCCTGAGG AGTACAGCCTCTTTCTCTTCGTTGACGAGACATGGCAGCAGCTGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCC GACCACAGCCCCACATCTTCCACTTTGTCTACAAACGCATCAAGAACGATCCTTATGGCATCATTTTCCAGAACGGGGAAGAAGACCTCA CCACCTCCTAGAAGACAGGCGGGACTTCCCAGTGGTGCATCCAAAGGGGAGCTGGAAGCCTTGCCTTCCCGCTTCTACATGCTTGAGCTT GAAAAGCAGTCACCTCCTCGGGGACCCCTCAGTGTAGTGACTAAGCCATCCACAGGCCAACTCGGCCAAGGGCAACTTTAGCCACGCAAG GTAGCTGAGGTTTGTGAAACAGTAGGATTCTCTTTTGGCAATGGAGAATTGCATCTGATGGTTCAAGTGTCCTGAGATTGTTTGCTACCT ACCCCCAGTCAGGTTCTAGGTTGGCTTACAGGTATGTATATGTGCAGAAGAAACACTTAAGATACAAGTTCTTTTGAATTCAACAGCAGA TGCTTGCGATGCAGTGCGTCAGGTGATTCTCACTCCTGTGGATGGCTTCATCCCTGCCTTCCTTCCTTTCTTTTTCCTTTTTTTTTTTTT TTTTTTTTTTTTTACAAAGAGCCTTCATGTTTTTATATATTTCATAGAAATTTTTATAGCAGTTGCAGGTAAACTGTCAGGATTGGTTTT AAAATATTTTTGTAACTTTAAAATATTCTATAATTATGCATGTGATTTTAACATTTAATATTCAAAAATAAATCTCTTGCTGGATTTGAG AGTATTGCATTTTTAAAGTCTCTCTTCTGTAACTGGATGTTTTGGCAACTTTGTGGGGAGAGACTGCTGGATTTCTTAAAGCAACGTATT CCTGACACTGGCCACAGAATGCCTTTGGAAATCGGATGTACTGTTCTCTTGTTCACGTTTAGTGGTGTTTTGCTGTTTTGTTTTTTAAAC AAATGATGCTGAGAATAAGGAGAGAAATGAATGTAGAGAGAGGTAGAGAGAGAAATATGAACTCTAACAAAGGACTGAGGAGTGCAGTCT GCTGGTTCAGGCTCTTCAAAAGATGTAGAAAAAGAGATAGAAGGAACCACCTATGCTTAAAATACTGTAAATATGCAGTGAGGTTTGGCA AAATCTATTCCATGTGTGATTTGCTTGTAGAAACAATTTTGAAAGCCCCTTGAGGAAAATAAAAATCAAGAAGAACACTTTTCTCCCTTT TCCATACAAATTAAAACTTAACAGCATCAAATTATTGGGACCAGAAACCAAGTAATGTATAATGTGGCTTTTGTTGAGTTAAATAAGATG CTATATAATGGAGAAGAATTTGAAAATGCACAAAAAAATCAATCTACATTATCAGAACCTGCAGTGAAATTAAACTTATGTTAAATAAAA CCAGTTTGCAGGTGCACAAACTATGAGGGTCTTGTATCCACGTAACACAGGTAGTTACAAAAACATGTTATTGTACTGTGTAAAGATGCA TAGTCATCTCATTTGGTTGGCTTTGTACCTTGTACCTTTTTTAGCCTTGGCTTTTGTTGAACTAGAACCCTCAGCACATACTGTGTTGTA CTTTTGTAAATGATTTTTTAAATGGAATTTTGCACATAATACATTGTAATACTGTATGATAATCATGTGTGAAAATAATTTTTGAAATAT >In-frame_XRN2_ENST00000377191_chr20_21284111_+_RIN2_ENST00000440354_chr20_19915743_+_1914nt ACGTGGGAGGAAGTGCTGGTGCCCTCTGCCGCTGCTCCCGTCTCTTTGGTTACGCTCGTCAGCCGGTCGGCCGCCGCCTCCAGCCGTGTG CCGCTATGGGAGTCCCGGCGTTCTTCCGCTGGCTCAGCCGCAAGTACCCGTCCATCATAGTCAACTGCGTGGAAGAGAAGCTCATTGACA CAATTGCCTCGGAGATCGGAGAACTGAAACAGGAGATGGTGCGGACAGATGTCAACCTGGAAAATGGCCTGGAACCCGCTGAAACCCACA GCATGGTAAGACACAAGGATGGTGGCTATTCCGAGGAAGAGGACGTGAAGACCTGTGCCCGGGACTCAGGCTATGACAGCCTCTCCAACA GGCTCAGCATCTTGGACCGGCTCCTCCACACCCACCCCATATGGCTGCAGCTGAGTCTGAGTGAGGAGGAGGCAGCAGAGGTCCTGCAGG CCCAGCCTCCGGGGATCTTCCTGGTTCATAAATCTACCAAGATGCAGAAGAAAGTCCTCTCCCTCCGCCTGCCCTGTGAATTTGGGGCCC CACTCAAGGAATTTGCCATAAAGGAAAGCACATACAATGTGGTGCTGGAAAAAGCCATGCACAAGTGCATCTTGAAGCCCCTCAAGGGGC ACGTGGAGGCCATGCTGAAGGACTTTCACATGGCCGATGGCTCATGGAAGCAACTCAAGGAGAACCTGCAGCTTGTGCGGCAGAGGAATC CGCAGGAGCTGGGGGTCTTCGCCCCGACCCCTGATTTTGTGGATGTGGAGAAAATCAAAGTCAAGTTCATGACCATGCAGAAGATGTATT CGCCGGAAAAGAAGGTCATGCTGCTGCTGCGGGTCTGCAAGCTCATTTACACGGTCATGGAGAACAACTCAGGGAGGATGTATGGCGCTG ATGACTTCTTGCCAGTCCTGACCTATGTCATAGCCCAGTGTGACATGCTTGAATTGGACACTGAAATCGAGTACATGATGGAGCTCCTAG ACCCATCGCTGTTACATGGAGAAGGAGGCTATTACTTGACAAGCGCATATGGAGCACTTTCTCTGATAAAGAATTTCCAAGAAGAACAAG CAGCGCGACTGCTCAGCTCAGAAACCAGAGACACCCTGAGGCAGTGGCACAAACGGAGAACCACCAACCGGACCATCCCCTCTGTGGACG ACTTCCAGAATTACCTCCGAGTTGCATTTCAGGAGGTCAACAGTGGTTGCACAGGAAAGACCCTCCTTGTGAGACCTTACATCACCACTG AGGATGTGTGTCAGATCTGCGCTGAGAAGTTCAAGGTGGGGGACCCTGAGGAGTACAGCCTCTTTCTCTTCGTTGACGAGACATGGCAGC AGCTGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCACAGCCCCACATCTTCCACTTTGTCTACAAACGCA TCAAGAACGATCCTTATGGCATCATTTTCCAGAACGGGGAAGAAGACCTCACCACCTCCTAGAAGACAGGCGGGACTTCCCAGTGGTGCA TCCAAAGGGGAGCTGGAAGCCTTGCCTTCCCGCTTCTACATGCTTGAGCTTGAAAAGCAGTCACCTCCTCGGGGACCCCTCAGTGTAGTG ACTAAGCCATCCACAGGCCAACTCGGCCAAGGGCAACTTTAGCCACGCAAGGTAGCTGAGGTTTGTGAAACAGTAGGATTCTCTTTTGGC AATGGAGAATTGCATCTGATGGTTCAAGTGTCCTGAGATTGTTTGCTACCTACCCCCAGTCAGGTTCTAGGTTGGCTTACAGGTATGTAT ATGTGCAGAAGAAACACTTAAGATACAAGTTCTTTTGAATTCAACAGCAGATGCTTGCGATGCAGTGCGTCAGGTGATTCTCACTCCTGT |
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FusionGenePPI for XRN2_RIN2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| XRN2 | TOLLIP, LSM3, DXO, UPF2, DISC1, DHX58, EIF2AK2, SIRT7, HNRNPA1, CUL3, CUL4B, CUL1, COPS5, CAND1, DENND5A, TXLNA, UBE2A, USP19, UNC13D, XPO1, XPO7, CSNK2A1, AICDA, PAN2, EIF3L, EEF1A1, ATRN, CTSC, EIF6, EIF5A, TIPARP, COMT, MOCS3, ALDH1B1, PRAME, MRPS10, MRPL4, EXOSC8, EXOSC10, PSMA3, TARDBP, RPA3, RPA2, RPA1, WWOX, ERG, LIN28A, CDKN2AIPNL, KPNA6, DHX8, POLR2A, KPNA1, NKRF, CDKN2AIP, POLR2B, LGALS3BP, MAGED2, ENO1, SHMT2, MOV10, NXF1, CUL7, OBSL1, BMI1, CFAP58, MCFD2, API5, NTRK1, HNRNPU, CRY2, MCM2, SNW1, CDC5L, SMN1, EGFR, WWP2, DCAF7, FOXA1, BRCA1, YAP1 | RIN2 | RAB5A, RAB5B, RIN2, ELAVL1, EGFR, ERBB2, CDKN2A, NAA11, NAA10 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for XRN2_RIN2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for XRN2_RIN2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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