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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42192

FusionGeneSummary for XPO6_XPO6

check button Fusion gene summary
Fusion gene informationFusion gene name: XPO6_XPO6
Fusion gene ID: 42192
HgeneTgene
Gene symbol

XPO6

XPO6

Gene ID

23214

23214

Gene nameexportin 6exportin 6
SynonymsEXP6|RANBP20EXP6|RANBP20
Cytomap

16p12.1

16p12.1

Type of geneprotein-codingprotein-coding
Descriptionexportin-6ran-binding protein 20exportin-6ran-binding protein 20
Modification date2018051920180519
UniProtAcc

Q96QU8

Q96QU8

Ensembl transtripts involved in fusion geneENST00000565698, ENST00000304658, 
ENST00000561488, 		ENST00000565698, 
ENST00000304658, ENST00000561488, 
Fusion gene scores* DoF score7 X 8 X 3=1683 X 5 X 2=30
# samples 106
** MAII scorelog2(10/168*10)=-0.748461233004036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: XPO6 [Title/Abstract] AND XPO6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXPO6

GO:0006611

protein export from nucleus

14592989

TgeneXPO6

GO:0006611

protein export from nucleus

14592989


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF353460XPO6chr16

28157483

+XPO6chr16

28167548

-
ChiTaRS3.1BU557309XPO6chr16

28124373

+XPO6chr16

28123292

-
ChiTaRS3.1BE183304XPO6chr16

28157483

+XPO6chr16

28167548

-
ChiTaRS3.1AA643733XPO6chr16

28109855

-XPO6chr16

28112058

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000565698ENST00000565698XPO6chr16

28157483

+XPO6chr16

28167548

-
intron-3CDSENST00000565698ENST00000304658XPO6chr16

28157483

+XPO6chr16

28167548

-
intron-5UTRENST00000565698ENST00000561488XPO6chr16

28157483

+XPO6chr16

28167548

-
intron-3CDSENST00000304658ENST00000565698XPO6chr16

28157483

+XPO6chr16

28167548

-
intron-3CDSENST00000304658ENST00000304658XPO6chr16

28157483

+XPO6chr16

28167548

-
intron-5UTRENST00000304658ENST00000561488XPO6chr16

28157483

+XPO6chr16

28167548

-
intron-3CDSENST00000561488ENST00000565698XPO6chr16

28157483

+XPO6chr16

28167548

-
intron-3CDSENST00000561488ENST00000304658XPO6chr16

28157483

+XPO6chr16

28167548

-
intron-5UTRENST00000561488ENST00000561488XPO6chr16

28157483

+XPO6chr16

28167548

-
intron-3CDSENST00000565698ENST00000565698XPO6chr16

28124373

+XPO6chr16

28123292

-
intron-3CDSENST00000565698ENST00000304658XPO6chr16

28124373

+XPO6chr16

28123292

-
intron-intronENST00000565698ENST00000561488XPO6chr16

28124373

+XPO6chr16

28123292

-
intron-3CDSENST00000304658ENST00000565698XPO6chr16

28124373

+XPO6chr16

28123292

-
intron-3CDSENST00000304658ENST00000304658XPO6chr16

28124373

+XPO6chr16

28123292

-
intron-intronENST00000304658ENST00000561488XPO6chr16

28124373

+XPO6chr16

28123292

-
intron-3CDSENST00000561488ENST00000565698XPO6chr16

28124373

+XPO6chr16

28123292

-
intron-3CDSENST00000561488ENST00000304658XPO6chr16

28124373

+XPO6chr16

28123292

-
intron-intronENST00000561488ENST00000561488XPO6chr16

28124373

+XPO6chr16

28123292

-
intron-intronENST00000565698ENST00000565698XPO6chr16

28109855

-XPO6chr16

28112058

-
intron-intronENST00000565698ENST00000304658XPO6chr16

28109855

-XPO6chr16

28112058

-
intron-intronENST00000565698ENST00000561488XPO6chr16

28109855

-XPO6chr16

28112058

-
intron-intronENST00000304658ENST00000565698XPO6chr16

28109855

-XPO6chr16

28112058

-
intron-intronENST00000304658ENST00000304658XPO6chr16

28109855

-XPO6chr16

28112058

-
intron-intronENST00000304658ENST00000561488XPO6chr16

28109855

-XPO6chr16

28112058

-
intron-intronENST00000561488ENST00000565698XPO6chr16

28109855

-XPO6chr16

28112058

-
intron-intronENST00000561488ENST00000304658XPO6chr16

28109855

-XPO6chr16

28112058

-
intron-intronENST00000561488ENST00000561488XPO6chr16

28109855

-XPO6chr16

28112058

-

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FusionProtFeatures for XPO6_XPO6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XPO6

Q96QU8

XPO6

Q96QU8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for XPO6_XPO6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for XPO6_XPO6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for XPO6_XPO6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for XPO6_XPO6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneXPO6C0236969Substance-Related Disorders1CTD_human
TgeneXPO6C0236969Substance-Related Disorders1CTD_human