FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42142

FusionGeneSummary for XAF1_SLC8A1

check button Fusion gene summary
Fusion gene informationFusion gene name: XAF1_SLC8A1
Fusion gene ID: 42142
HgeneTgene
Gene symbol

XAF1

SLC8A1

Gene ID

54739

6546

Gene nameXIAP associated factor 1solute carrier family 8 member A1
SynonymsBIRC4BP|HSXIAPAF1|XIAPAF1NCX1
Cytomap

17p13.1

2p22.1

Type of geneprotein-codingprotein-coding
DescriptionXIAP-associated factor 1BIRC4-binding proteinsodium/calcium exchanger 1Na(+)/Ca(2+)-exchange protein 1Na+/Ca++ exchangerNa+/Ca2+ exchangersolute carrier family 8 (sodium/calcium exchanger), member 1solute carrier family 8 member 1
Modification date2018052020180527
UniProtAcc

Q6GPH4

P32418

Ensembl transtripts involved in fusion geneENST00000438512, ENST00000441631, 
ENST00000346752, ENST00000361842, 
ENST00000576459, 
ENST00000406785, 
ENST00000542756, ENST00000403092, 
ENST00000405901, ENST00000402441, 
ENST00000405269, ENST00000542024, 
ENST00000332839, ENST00000406391, 
ENST00000408028, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 3=75
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: XAF1 [Title/Abstract] AND SLC8A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXAF1

GO:0035456

response to interferon-beta

18035482

TgeneSLC8A1

GO:0006883

cellular sodium ion homeostasis

1374913

TgeneSLC8A1

GO:0070509

calcium ion import

1374913

TgeneSLC8A1

GO:0098719

sodium ion import across plasma membrane

1374913


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF986040XAF1chr17

6678695

-SLC8A1chr2

40655518

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000438512ENST00000406785XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000438512ENST00000542756XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000438512ENST00000403092XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000438512ENST00000405901XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000438512ENST00000402441XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000438512ENST00000405269XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000438512ENST00000542024XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000438512ENST00000332839XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000438512ENST00000406391XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000438512ENST00000408028XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000441631ENST00000406785XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000441631ENST00000542756XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000441631ENST00000403092XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000441631ENST00000405901XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000441631ENST00000402441XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000441631ENST00000405269XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000441631ENST00000542024XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000441631ENST00000332839XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000441631ENST00000406391XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000441631ENST00000408028XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000346752ENST00000406785XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000346752ENST00000542756XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000346752ENST00000403092XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000346752ENST00000405901XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000346752ENST00000402441XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000346752ENST00000405269XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000346752ENST00000542024XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000346752ENST00000332839XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000346752ENST00000406391XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000346752ENST00000408028XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000361842ENST00000406785XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000361842ENST00000542756XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000361842ENST00000403092XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000361842ENST00000405901XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000361842ENST00000402441XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000361842ENST00000405269XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000361842ENST00000542024XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000361842ENST00000332839XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000361842ENST00000406391XAF1chr17

6678695

-SLC8A1chr2

40655518

-
3UTR-intronENST00000361842ENST00000408028XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000576459ENST00000406785XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000576459ENST00000542756XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000576459ENST00000403092XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000576459ENST00000405901XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000576459ENST00000402441XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000576459ENST00000405269XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000576459ENST00000542024XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000576459ENST00000332839XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000576459ENST00000406391XAF1chr17

6678695

-SLC8A1chr2

40655518

-
intron-intronENST00000576459ENST00000408028XAF1chr17

6678695

-SLC8A1chr2

40655518

-

Top

FusionProtFeatures for XAF1_SLC8A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
XAF1

Q6GPH4

SLC8A1

P32418


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for XAF1_SLC8A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for XAF1_SLC8A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for XAF1_SLC8A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for XAF1_SLC8A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneXAF1C0009375Colonic Neoplasms2CTD_human
HgeneXAF1C0009404Colorectal Neoplasms1CTD_human
HgeneXAF1C0021400Influenza1CTD_human
HgeneXAF1C0038356Stomach Neoplasms1CTD_human
TgeneSLC8A1C0025160Megacolon2CTD_human
TgeneSLC8A1C0027055Myocardial Reperfusion Injury1CTD_human
TgeneSLC8A1C0036572Seizures1CTD_human
TgeneSLC8A1C0038220Status Epilepticus1CTD_human
TgeneSLC8A1C0151744Myocardial Ischemia1CTD_human