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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42122

FusionGeneSummary for WWP1_LRRCC1

check button Fusion gene summary
Fusion gene informationFusion gene name: WWP1_LRRCC1
Fusion gene ID: 42122
HgeneTgene
Gene symbol

WWP1

LRRCC1

Gene ID

11059

85444

Gene nameWW domain containing E3 ubiquitin protein ligase 1leucine rich repeat and coiled-coil centrosomal protein 1
SynonymsAIP5|Tiul1|hSDRP1CLERC|CLERK|SAP2|VFL1
Cytomap

8q21.3

8q21.2

Type of geneprotein-codingprotein-coding
DescriptionNEDD4-like E3 ubiquitin-protein ligase WWP1HECT-type E3 ubiquitin transferase WWP1Nedd-4-like ubiquitin-protein ligaseTGIF-interacting ubiquitin ligase 1WW domain-containing protein 1atrophin-1 interacting protein 5leucine-rich repeat and coiled-coil domain-containing protein 1centrosomal leucine-rich repeat and coiled-coil domain-containing proteinsodium channel associated protein 2variable number of flagella 1 homolog
Modification date2018052320180523
UniProtAcc

Q9H0M0

Q9C099

Ensembl transtripts involved in fusion geneENST00000517970, ENST00000349423, 
ENST00000341922, ENST00000265428, 
ENST00000523863, 
ENST00000360375, 
ENST00000414626, 
Fusion gene scores* DoF score9 X 8 X 6=4324 X 4 X 4=64
# samples 94
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WWP1 [Title/Abstract] AND LRRCC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-EP-A2KA-01AWWP1chr8

87355159

+LRRCC1chr8

86053617

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000517970ENST00000360375WWP1chr8

87355159

+LRRCC1chr8

86053617

+
5UTR-3CDSENST00000517970ENST00000414626WWP1chr8

87355159

+LRRCC1chr8

86053617

+
intron-3CDSENST00000349423ENST00000360375WWP1chr8

87355159

+LRRCC1chr8

86053617

+
intron-3CDSENST00000349423ENST00000414626WWP1chr8

87355159

+LRRCC1chr8

86053617

+
intron-3CDSENST00000341922ENST00000360375WWP1chr8

87355159

+LRRCC1chr8

86053617

+
intron-3CDSENST00000341922ENST00000414626WWP1chr8

87355159

+LRRCC1chr8

86053617

+
intron-3CDSENST00000265428ENST00000360375WWP1chr8

87355159

+LRRCC1chr8

86053617

+
intron-3CDSENST00000265428ENST00000414626WWP1chr8

87355159

+LRRCC1chr8

86053617

+
3UTR-3CDSENST00000523863ENST00000360375WWP1chr8

87355159

+LRRCC1chr8

86053617

+
3UTR-3CDSENST00000523863ENST00000414626WWP1chr8

87355159

+LRRCC1chr8

86053617

+

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FusionProtFeatures for WWP1_LRRCC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WWP1

Q9H0M0

LRRCC1

Q9C099

E3 ubiquitin-protein ligase which accepts ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates.Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5and TP63 and promotes their proteasomal degradation. UbiquitinatesRNF11 without targeting it for degradation. Ubiquitinates andpromotes degradation of TGFBR1; the ubiquitination is enhanced bySMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotesdegradation of SMAD2 in response to TGF-beta signaling, whichrequires interaction with TGIF. {ECO:0000269|PubMed:12535537,ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:15359284}. Required for the organization of the mitotic spindle.Maintains the structural integrity of centrosomes during mitosis.{ECO:0000269|PubMed:18728398}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WWP1_LRRCC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WWP1_LRRCC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WWP1ZNF638, CPSF6, EWSR1, DAZAP2, DIDO1, WBP1, WBP2, KLF2, SCNN1A, ATN1, RTN4, KLF5, PCBD1, STAT6, LZTR1, IKBKG, SMAD2, SMAD3, SMAD1, SMAD5, SMAD6, SMAD7, SKIL, ERBB4, ESR2, RNF11, SFTPC, SPG20, TP63, ARRDC1, ARRDC2, ARRDC3, EZR, HIVEP3, RUNX2, SMAD4, LNX1, PTPN14, UBE2L3, PRKAA2, HSP90AA1, FBXL15, LAPTM5, TRAF6, H2AFY2, PHF20L1, ASH2L, YWHAQ, NOTCH1, PTCH1, WWP1, FAM189A2, TRAF4, FBXL18, LATS1, EZH2, FAM189B, TMEM51, TMEM255B, TMEM255A, LDLRAD4, PTEN, HSPB1, CDK8, XRCC5, SETD4, LITAF, UBC, UBE2D1, UBE2D2, UBE2D3, DVL2, ITCH, WWP2, SARAF, TNFRSF19, TXNIP, ILDR1, PTPN21LRRCC1PCM1, MYH7B, ACTN3, CEP131, ATP1A4, ATP2A3, POTEE, ATP2A1, PIBF1, SKA3, TUBA3C, KIF7, MIB1, STRIP1, STRN, FBXO28, MED4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WWP1_LRRCC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WWP1_LRRCC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource