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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42118

FusionGeneSummary for WWP1_ATP6V0D2

check button Fusion gene summary
Fusion gene informationFusion gene name: WWP1_ATP6V0D2
Fusion gene ID: 42118
HgeneTgene
Gene symbol

WWP1

ATP6V0D2

Gene ID

11059

245972

Gene nameWW domain containing E3 ubiquitin protein ligase 1ATPase H+ transporting V0 subunit d2
SynonymsAIP5|Tiul1|hSDRP1ATP6D2|VMA6
Cytomap

8q21.3

8q21.3

Type of geneprotein-codingprotein-coding
DescriptionNEDD4-like E3 ubiquitin-protein ligase WWP1HECT-type E3 ubiquitin transferase WWP1Nedd-4-like ubiquitin-protein ligaseTGIF-interacting ubiquitin ligase 1WW domain-containing protein 1atrophin-1 interacting protein 5V-type proton ATPase subunit d 2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2V-ATPase subunit d 2vacuolar proton pump subunit d 2
Modification date2018052320180523
UniProtAcc

Q9H0M0

Q8N8Y2

Ensembl transtripts involved in fusion geneENST00000517970, ENST00000349423, 
ENST00000341922, ENST00000265428, 
ENST00000523863, 
ENST00000285393, 
Fusion gene scores* DoF score9 X 8 X 6=4322 X 2 X 2=8
# samples 92
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: WWP1 [Title/Abstract] AND ATP6V0D2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A15A-01AWWP1chr8

87381260

+ATP6V0D2chr8

87151686

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000517970ENST00000285393WWP1chr8

87381260

+ATP6V0D2chr8

87151686

+
intron-3CDSENST00000349423ENST00000285393WWP1chr8

87381260

+ATP6V0D2chr8

87151686

+
intron-3CDSENST00000341922ENST00000285393WWP1chr8

87381260

+ATP6V0D2chr8

87151686

+
intron-3CDSENST00000265428ENST00000285393WWP1chr8

87381260

+ATP6V0D2chr8

87151686

+
3UTR-3CDSENST00000523863ENST00000285393WWP1chr8

87381260

+ATP6V0D2chr8

87151686

+

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FusionProtFeatures for WWP1_ATP6V0D2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WWP1

Q9H0M0

ATP6V0D2

Q8N8Y2

E3 ubiquitin-protein ligase which accepts ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates.Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5and TP63 and promotes their proteasomal degradation. UbiquitinatesRNF11 without targeting it for degradation. Ubiquitinates andpromotes degradation of TGFBR1; the ubiquitination is enhanced bySMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotesdegradation of SMAD2 in response to TGF-beta signaling, whichrequires interaction with TGIF. {ECO:0000269|PubMed:12535537,ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:15359284}. Subunit of the integral membrane V0 complex of vacuolarATPase. Vacuolar ATPase is responsible for acidifying a variety ofintracellular compartments in eukaryotic cells, thus providingmost of the energy required for transport processes in thevacuolar system. May play a role in coupling of proton transportand ATP hydrolysis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WWP1_ATP6V0D2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WWP1_ATP6V0D2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WWP1ZNF638, CPSF6, EWSR1, DAZAP2, DIDO1, WBP1, WBP2, KLF2, SCNN1A, ATN1, RTN4, KLF5, PCBD1, STAT6, LZTR1, IKBKG, SMAD2, SMAD3, SMAD1, SMAD5, SMAD6, SMAD7, SKIL, ERBB4, ESR2, RNF11, SFTPC, SPG20, TP63, ARRDC1, ARRDC2, ARRDC3, EZR, HIVEP3, RUNX2, SMAD4, LNX1, PTPN14, UBE2L3, PRKAA2, HSP90AA1, FBXL15, LAPTM5, TRAF6, H2AFY2, PHF20L1, ASH2L, YWHAQ, NOTCH1, PTCH1, WWP1, FAM189A2, TRAF4, FBXL18, LATS1, EZH2, FAM189B, TMEM51, TMEM255B, TMEM255A, LDLRAD4, PTEN, HSPB1, CDK8, XRCC5, SETD4, LITAF, UBC, UBE2D1, UBE2D2, UBE2D3, DVL2, ITCH, WWP2, SARAF, TNFRSF19, TXNIP, ILDR1, PTPN21ATP6V0D2ADRM1, AGO3, NDUFB8, RPS3, RBM15B, ATP6AP2, TMEM185A, ATP6V1B1, ATP6V0A2, ATP6V0D1, VMA21, TMEM199, TCIRG1, CCDC115, ATP6V0A1, ATP6V0C, FKBP15, KIAA2013


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WWP1_ATP6V0D2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WWP1_ATP6V0D2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneATP6V0D2C0029927Ovarian Cysts1CTD_human
TgeneATP6V0D2C0038356Stomach Neoplasms1CTD_human