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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42112

FusionGeneSummary for WWOX_CDH3

check button Fusion gene summary
Fusion gene informationFusion gene name: WWOX_CDH3
Fusion gene ID: 42112
HgeneTgene
Gene symbol

WWOX

CDH3

Gene ID

51741

1013

Gene nameWW domain containing oxidoreductasecadherin 15
SynonymsD16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1CDH14|CDH3|CDHM|MCAD|MRD3
Cytomap

16q23.1-q23.2

16q24.3

Type of geneprotein-codingprotein-coding
DescriptionWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1cadherin-15cadherin 15, type 1, M-cadherin (myotubule)cadherin-14cadherin-3muscle-cadherin
Modification date2018052320180523
UniProtAcc

Q9NZC7

P22223

Ensembl transtripts involved in fusion geneENST00000566780, ENST00000406884, 
ENST00000539474, ENST00000402655, 
ENST00000408984, ENST00000355860, 
ENST00000565791, ENST00000569818, 
ENST00000264012, ENST00000429102, 
ENST00000581171, ENST00000569117, 
Fusion gene scores* DoF score9 X 10 X 7=6306 X 6 X 4=144
# samples 146
** MAII scorelog2(14/630*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WWOX [Title/Abstract] AND CDH3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

HgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDACCTCGA-OR-A5JY-01AWWOXchr16

78198186

+CDH3chr16

68756328

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000566780ENST00000264012WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000566780ENST00000429102WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000566780ENST00000581171WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000566780ENST00000569117WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000406884ENST00000264012WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000406884ENST00000429102WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000406884ENST00000581171WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000406884ENST00000569117WWOXchr16

78198186

+CDH3chr16

68756328

+
intron-intronENST00000539474ENST00000264012WWOXchr16

78198186

+CDH3chr16

68756328

+
intron-intronENST00000539474ENST00000429102WWOXchr16

78198186

+CDH3chr16

68756328

+
intron-intronENST00000539474ENST00000581171WWOXchr16

78198186

+CDH3chr16

68756328

+
intron-intronENST00000539474ENST00000569117WWOXchr16

78198186

+CDH3chr16

68756328

+
intron-intronENST00000402655ENST00000264012WWOXchr16

78198186

+CDH3chr16

68756328

+
intron-intronENST00000402655ENST00000429102WWOXchr16

78198186

+CDH3chr16

68756328

+
intron-intronENST00000402655ENST00000581171WWOXchr16

78198186

+CDH3chr16

68756328

+
intron-intronENST00000402655ENST00000569117WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000408984ENST00000264012WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000408984ENST00000429102WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000408984ENST00000581171WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000408984ENST00000569117WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000355860ENST00000264012WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000355860ENST00000429102WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000355860ENST00000581171WWOXchr16

78198186

+CDH3chr16

68756328

+
5CDS-intronENST00000355860ENST00000569117WWOXchr16

78198186

+CDH3chr16

68756328

+
3UTR-intronENST00000565791ENST00000264012WWOXchr16

78198186

+CDH3chr16

68756328

+
3UTR-intronENST00000565791ENST00000429102WWOXchr16

78198186

+CDH3chr16

68756328

+
3UTR-intronENST00000565791ENST00000581171WWOXchr16

78198186

+CDH3chr16

68756328

+
3UTR-intronENST00000565791ENST00000569117WWOXchr16

78198186

+CDH3chr16

68756328

+
intron-intronENST00000569818ENST00000264012WWOXchr16

78198186

+CDH3chr16

68756328

+
intron-intronENST00000569818ENST00000429102WWOXchr16

78198186

+CDH3chr16

68756328

+
intron-intronENST00000569818ENST00000581171WWOXchr16

78198186

+CDH3chr16

68756328

+
intron-intronENST00000569818ENST00000569117WWOXchr16

78198186

+CDH3chr16

68756328

+

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FusionProtFeatures for WWOX_CDH3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WWOX

Q9NZC7

CDH3

P22223

Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WWOX_CDH3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WWOX_CDH3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WWOXTP53, CPSF6, TNK2, ERBB4, MDM2, TP63, MAPK8, LMNA, POLR2A, POLR2B, SMARCC1, TCERG1, CPSF1, CPSF2, CPSF3, NUDT21, FIP1L1, CPSF7, HNRNPK, RPRD2, PABPC1, SF3A1, SF3B1, SF3B3, SFPQ, SYMPK, WIPF2, WDR33, WBP2, SF3B2, KHSRP, CSTF3, HSPA4, DHX15, KRT4, MIA3, OTUD7B, PRPF8, ACIN1, PATL1, P4HA1, DSP, ANXA1, HSPA1A, PRRC2A, SERPINB3, COIL, PGD, DIAPH3, CSNK2A1, SNRNP200, DAZAP1, RPRD1B, HSPA8, ENAH, PABPC4, IGF2BP1, HSD17B10, HDLBP, DVL2, SF3A3, CCT2, SNRPD2, SMARCA4, CDC5L, YWHAZ, UBAP2, CANX, SNRPD1, JUP, RARA, PRMT5, U2SURP, TGM3, TDRD3, PKLR, NOLC1, YLPM1, WASL, CSTF2, MATR3, TOE1, BCL9, CRNN, HIST2H2AA3, DVL3, P3H1, PRPF3, CSNK2A2, SCAF4, DSG3, RBMX, CYFIP1, USP6NL, DDX6, XRN2, IVL, XAB2, AMOTL1, MPDZ, DDX3Y, HNRNPUL1, DHX9, POLR2E, FBRS, WDR77, SEC23A, ZMAT5, DGCR14, LZTS2, NOSIP, DCAF7, GEMIN5, PRPF40A, EIF4A3, INPPL1, LSM4, DDX17, IGF2BP3, RC3H1, MPP5, POLR2C, FARSA, HNRNPH3, DHX30, RPRD1A, ZG16B, NONO, PREB, PABPC3, LONP2, ATN1, GABARAPL2, HNRNPR, HNRNPCL1, CYFIP2, ELAVL1, ITCH, DRG1, SNRPD3, RPAP3, DROSHA, HNRNPU, SMN2, CAD, CCT7, PTPN14, PPP1CA, HNRNPA3, DDX39B, SCGB2A1, KRT75, DDX21, SPG20, CSDE1, HNRNPF, SRSF10, SEC23IP, ATP2A1, DIAPH1, LCN1, DOCK7, CXorf57, SF3A2, HSPB1, TARDBP, SF3B6, A2ML1, AMOT, THOC6, KIF2A, LUC7L3, MYH7, MYH1, MYH4, MYH16, DDX1, ENO1, TP73, CCT6A, SMARCE1, ANXA2, ACLY, SCAF8, ALDH3A1, PPIB, EDC4, RPL6, USP39, EIF3A, H2AFZ, RPL30, KDM3B, FUS, SERPINB5, DVL1, RAPGEF2, DHX36, HN1L, POLR2G, BAIAP2, WDR91, DCTPP1, IQSEC1, PRDX5, LZTS3, RPS15AP21, SRSF3, ZNF598, LACRT, IGF2BP2, PAICS, KIAA1522, SLC4A1AP, ATXN2, THRAP3, RBM39, CAPZA1, SEC24C, NOP56, SRPK1, DKC1, IK, HADHA, OGT, PRPF31, DIDO1, ATAD3A, PDCD7, HUWE1, ATM, TRIM28, HIF1A, LATS1, FAM189B, TMEM171, FAM189A2, WBP1, TMEM92, LDLRAD4, CLNK, BTRC, NUP133, CDH1, FKBP15, SERPINA5, ARRDC3, NME2, GORASP1, ZBTB33, LYZ, TRIM25, BRCA1CDH3CDH1, CDH3, CTNNA1, CTNNB1, JUP, CTNND1, AP2M1, CTNNA3, PCDHGB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WWOX_CDH3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WWOX_CDH3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWWOXC0007137Squamous cell carcinoma1CTD_human
HgeneWWOXC0038356Stomach Neoplasms1CTD_human
HgeneWWOXC0042076Urologic Neoplasms1CTD_human
HgeneWWOXC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneWWOXC1458155Mammary Neoplasms1CTD_human
HgeneWWOXC3280452SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 121ORPHANET;UNIPROT
HgeneWWOXC3495559Juvenile arthritis1CTD_human
HgeneWWOXC4015519EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 281UNIPROT
TgeneCDH3C0009324Ulcerative Colitis1CTD_human
TgeneCDH3C0029927Ovarian Cysts1CTD_human
TgeneCDH3C1832162HYPOTRICHOSIS, CONGENITAL, WITH JUVENILE MACULAR DYSTROPHY1CTD_human;ORPHANET;UNIPROT
TgeneCDH3C1857041Ectodermal dysplasia, ectrodactyly, and macular dystrophy1CTD_human;ORPHANET;UNIPROT