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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42107

FusionGeneSummary for WWC3_PRR13

check button Fusion gene summary
Fusion gene informationFusion gene name: WWC3_PRR13
Fusion gene ID: 42107
HgeneTgene
Gene symbol

WWC3

PRR13

Gene ID

55841

54458

Gene nameWWC family member 3proline rich 13
SynonymsBM042TXR1
Cytomap

Xp22.2

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionprotein WWC3proline-rich protein 13taxane-resistance protein
Modification date2018051920180519
UniProtAcc

Q9ULE0

Q9NZ81

Ensembl transtripts involved in fusion geneENST00000380861, ENST00000454666, 
ENST00000466248, 
ENST00000429243, 
ENST00000549924, ENST00000551003, 
ENST00000549068, ENST00000549740, 
ENST00000546581, ENST00000549581, 
ENST00000547368, ENST00000379786, 
ENST00000549135, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: WWC3 [Title/Abstract] AND PRR13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWC3

GO:0000122

negative regulation of transcription by RNA polymerase II

24682284

HgeneWWC3

GO:0035331

negative regulation of hippo signaling

24682284


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ650497WWC3chrX

10096145

+PRR13chr12

53837325

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000380861ENST00000429243WWC3chrX

10096145

+PRR13chr12

53837325

+
Frame-shiftENST00000380861ENST00000549924WWC3chrX

10096145

+PRR13chr12

53837325

+
Frame-shiftENST00000380861ENST00000551003WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000380861ENST00000549068WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000380861ENST00000549740WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000380861ENST00000546581WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000380861ENST00000549581WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000380861ENST00000547368WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000380861ENST00000379786WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000380861ENST00000549135WWC3chrX

10096145

+PRR13chr12

53837325

+
Frame-shiftENST00000454666ENST00000429243WWC3chrX

10096145

+PRR13chr12

53837325

+
Frame-shiftENST00000454666ENST00000549924WWC3chrX

10096145

+PRR13chr12

53837325

+
Frame-shiftENST00000454666ENST00000551003WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000454666ENST00000549068WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000454666ENST00000549740WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000454666ENST00000546581WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000454666ENST00000549581WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000454666ENST00000547368WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000454666ENST00000379786WWC3chrX

10096145

+PRR13chr12

53837325

+
5CDS-intronENST00000454666ENST00000549135WWC3chrX

10096145

+PRR13chr12

53837325

+
intron-3CDSENST00000466248ENST00000429243WWC3chrX

10096145

+PRR13chr12

53837325

+
intron-3CDSENST00000466248ENST00000549924WWC3chrX

10096145

+PRR13chr12

53837325

+
intron-3CDSENST00000466248ENST00000551003WWC3chrX

10096145

+PRR13chr12

53837325

+
intron-intronENST00000466248ENST00000549068WWC3chrX

10096145

+PRR13chr12

53837325

+
intron-intronENST00000466248ENST00000549740WWC3chrX

10096145

+PRR13chr12

53837325

+
intron-intronENST00000466248ENST00000546581WWC3chrX

10096145

+PRR13chr12

53837325

+
intron-intronENST00000466248ENST00000549581WWC3chrX

10096145

+PRR13chr12

53837325

+
intron-intronENST00000466248ENST00000547368WWC3chrX

10096145

+PRR13chr12

53837325

+
intron-intronENST00000466248ENST00000379786WWC3chrX

10096145

+PRR13chr12

53837325

+
intron-intronENST00000466248ENST00000549135WWC3chrX

10096145

+PRR13chr12

53837325

+

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FusionProtFeatures for WWC3_PRR13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WWC3

Q9ULE0

PRR13

Q9NZ81

Negatively regulates TSP1 expression at the level oftranscription. This down-regulation was shown to reduce taxane-induced apoptosis. {ECO:0000269|PubMed:16847352}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WWC3_PRR13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WWC3_PRR13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WWC3_PRR13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WWC3_PRR13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRR13C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgenePRR13C0023893Liver Cirrhosis, Experimental1CTD_human