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Fusion gene ID: 42105 |
FusionGeneSummary for WWC2_CCDC110 |
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Fusion gene information | Fusion gene name: WWC2_CCDC110 | Fusion gene ID: 42105 | Hgene | Tgene | Gene symbol | WWC2 | CCDC110 | Gene ID | 80014 | 256309 |
Gene name | WW and C2 domain containing 2 | coiled-coil domain containing 110 | |
Synonyms | BOMB | CT52|KM-HN-1|KMHN1 | |
Cytomap | 4q35.1 | 4q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein WWC2BH3-only member B proteinWW, C2 and coiled-coil domain containing 2 | coiled-coil domain-containing protein 110cancer/testis antigen 52cancer/testis antigen KM-HN-1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q6AWC2 | Q8TBZ0 | |
Ensembl transtripts involved in fusion gene | ENST00000403733, ENST00000378925, ENST00000513834, ENST00000448232, ENST00000504005, ENST00000506225, ENST00000508747, | ENST00000393540, ENST00000307588, ENST00000510617, ENST00000507501, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 4 X 3=36 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: WWC2 [Title/Abstract] AND CCDC110 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | WWC2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 24682284 |
Hgene | WWC2 | GO:0035331 | negative regulation of hippo signaling | 24682284 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-H7-A6C4-01A | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000403733 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
Frame-shift | ENST00000403733 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
Frame-shift | ENST00000403733 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
5CDS-5UTR | ENST00000403733 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
5UTR-3CDS | ENST00000378925 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
5UTR-3CDS | ENST00000378925 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
5UTR-3CDS | ENST00000378925 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
5UTR-5UTR | ENST00000378925 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
Frame-shift | ENST00000513834 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
Frame-shift | ENST00000513834 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
Frame-shift | ENST00000513834 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
5CDS-5UTR | ENST00000513834 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
Frame-shift | ENST00000448232 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
Frame-shift | ENST00000448232 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
Frame-shift | ENST00000448232 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
5CDS-5UTR | ENST00000448232 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
intron-3CDS | ENST00000504005 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
intron-3CDS | ENST00000504005 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
intron-3CDS | ENST00000504005 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
intron-5UTR | ENST00000504005 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
intron-3CDS | ENST00000506225 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
intron-3CDS | ENST00000506225 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
intron-3CDS | ENST00000506225 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
intron-5UTR | ENST00000506225 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
intron-3CDS | ENST00000508747 | ENST00000393540 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
intron-3CDS | ENST00000508747 | ENST00000307588 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
intron-3CDS | ENST00000508747 | ENST00000510617 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
intron-5UTR | ENST00000508747 | ENST00000507501 | WWC2 | chr4 | 184020775 | + | CCDC110 | chr4 | 186392203 | - |
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FusionProtFeatures for WWC2_CCDC110 |
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Hgene | Tgene |
WWC2 | CCDC110 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WWC2_CCDC110 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WWC2_CCDC110 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
WWC2 | PTPN14, REPS1, YWHAQ, LDLRAD4, WWC2, WWC1, WWC3, PRKCA, LATS2, LATS1, DLC1, XPO1, EGFR, PTPN21, RHPN1 | CCDC110 | CUL3, CAND1, DEPTOR, XDH |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WWC2_CCDC110 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WWC2_CCDC110 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |