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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42105

FusionGeneSummary for WWC2_CCDC110

check button Fusion gene summary
Fusion gene informationFusion gene name: WWC2_CCDC110
Fusion gene ID: 42105
HgeneTgene
Gene symbol

WWC2

CCDC110

Gene ID

80014

256309

Gene nameWW and C2 domain containing 2coiled-coil domain containing 110
SynonymsBOMBCT52|KM-HN-1|KMHN1
Cytomap

4q35.1

4q35.1

Type of geneprotein-codingprotein-coding
Descriptionprotein WWC2BH3-only member B proteinWW, C2 and coiled-coil domain containing 2coiled-coil domain-containing protein 110cancer/testis antigen 52cancer/testis antigen KM-HN-1
Modification date2018051920180519
UniProtAcc

Q6AWC2

Q8TBZ0

Ensembl transtripts involved in fusion geneENST00000403733, ENST00000378925, 
ENST00000513834, ENST00000448232, 
ENST00000504005, ENST00000506225, 
ENST00000508747, 		ENST00000393540, 
ENST00000307588, ENST00000510617, 
ENST00000507501, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 4 X 3=36
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WWC2 [Title/Abstract] AND CCDC110 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWC2

GO:0000122

negative regulation of transcription by RNA polymerase II

24682284

HgeneWWC2

GO:0035331

negative regulation of hippo signaling

24682284


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-H7-A6C4-01AWWC2chr4

184020775

+CCDC110chr4

186392203

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000403733ENST00000393540WWC2chr4

184020775

+CCDC110chr4

186392203

-
Frame-shiftENST00000403733ENST00000307588WWC2chr4

184020775

+CCDC110chr4

186392203

-
Frame-shiftENST00000403733ENST00000510617WWC2chr4

184020775

+CCDC110chr4

186392203

-
5CDS-5UTRENST00000403733ENST00000507501WWC2chr4

184020775

+CCDC110chr4

186392203

-
5UTR-3CDSENST00000378925ENST00000393540WWC2chr4

184020775

+CCDC110chr4

186392203

-
5UTR-3CDSENST00000378925ENST00000307588WWC2chr4

184020775

+CCDC110chr4

186392203

-
5UTR-3CDSENST00000378925ENST00000510617WWC2chr4

184020775

+CCDC110chr4

186392203

-
5UTR-5UTRENST00000378925ENST00000507501WWC2chr4

184020775

+CCDC110chr4

186392203

-
Frame-shiftENST00000513834ENST00000393540WWC2chr4

184020775

+CCDC110chr4

186392203

-
Frame-shiftENST00000513834ENST00000307588WWC2chr4

184020775

+CCDC110chr4

186392203

-
Frame-shiftENST00000513834ENST00000510617WWC2chr4

184020775

+CCDC110chr4

186392203

-
5CDS-5UTRENST00000513834ENST00000507501WWC2chr4

184020775

+CCDC110chr4

186392203

-
Frame-shiftENST00000448232ENST00000393540WWC2chr4

184020775

+CCDC110chr4

186392203

-
Frame-shiftENST00000448232ENST00000307588WWC2chr4

184020775

+CCDC110chr4

186392203

-
Frame-shiftENST00000448232ENST00000510617WWC2chr4

184020775

+CCDC110chr4

186392203

-
5CDS-5UTRENST00000448232ENST00000507501WWC2chr4

184020775

+CCDC110chr4

186392203

-
intron-3CDSENST00000504005ENST00000393540WWC2chr4

184020775

+CCDC110chr4

186392203

-
intron-3CDSENST00000504005ENST00000307588WWC2chr4

184020775

+CCDC110chr4

186392203

-
intron-3CDSENST00000504005ENST00000510617WWC2chr4

184020775

+CCDC110chr4

186392203

-
intron-5UTRENST00000504005ENST00000507501WWC2chr4

184020775

+CCDC110chr4

186392203

-
intron-3CDSENST00000506225ENST00000393540WWC2chr4

184020775

+CCDC110chr4

186392203

-
intron-3CDSENST00000506225ENST00000307588WWC2chr4

184020775

+CCDC110chr4

186392203

-
intron-3CDSENST00000506225ENST00000510617WWC2chr4

184020775

+CCDC110chr4

186392203

-
intron-5UTRENST00000506225ENST00000507501WWC2chr4

184020775

+CCDC110chr4

186392203

-
intron-3CDSENST00000508747ENST00000393540WWC2chr4

184020775

+CCDC110chr4

186392203

-
intron-3CDSENST00000508747ENST00000307588WWC2chr4

184020775

+CCDC110chr4

186392203

-
intron-3CDSENST00000508747ENST00000510617WWC2chr4

184020775

+CCDC110chr4

186392203

-
intron-5UTRENST00000508747ENST00000507501WWC2chr4

184020775

+CCDC110chr4

186392203

-

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FusionProtFeatures for WWC2_CCDC110


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WWC2

Q6AWC2

CCDC110

Q8TBZ0


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WWC2_CCDC110


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WWC2_CCDC110


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WWC2PTPN14, REPS1, YWHAQ, LDLRAD4, WWC2, WWC1, WWC3, PRKCA, LATS2, LATS1, DLC1, XPO1, EGFR, PTPN21, RHPN1CCDC110CUL3, CAND1, DEPTOR, XDH


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WWC2_CCDC110


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WWC2_CCDC110


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource