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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42102

FusionGeneSummary for WWC1_RARS

check button Fusion gene summary
Fusion gene informationFusion gene name: WWC1_RARS
Fusion gene ID: 42102
HgeneTgene
Gene symbol

WWC1

RARS

Gene ID

23286

5917

Gene nameWW and C2 domain containing 1arginyl-tRNA synthetase
SynonymsHBEBP3|HBEBP36|KIBRA|MEMRYQTL|PPP1R168ArgRS|DALRD1|HLD9
Cytomap

5q34

5q34

Type of geneprotein-codingprotein-coding
Descriptionprotein KIBRAHBeAg-binding protein 3WW, C2 and coiled-coil domain containing 1kidney and brain proteinprotein WWC1protein phosphatase 1, regulatory subunit 168arginine--tRNA ligase, cytoplasmicarginine tRNA ligase 1, cytoplasmicarginyl-tRNA synthetase, cytoplasmic
Modification date2018051920180523
UniProtAcc

Q8IX03

P54136

Ensembl transtripts involved in fusion geneENST00000265293, ENST00000521089, 
ENST00000522140, 
ENST00000231572, 
ENST00000538719, ENST00000520421, 
Fusion gene scores* DoF score4 X 4 X 3=482 X 2 X 2=8
# samples 42
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: WWC1 [Title/Abstract] AND RARS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWC1

GO:0000122

negative regulation of transcription by RNA polymerase II

24682284

HgeneWWC1

GO:0016477

cell migration

18596123

HgeneWWC1

GO:0035331

negative regulation of hippo signaling

24682284

HgeneWWC1

GO:0043410

positive regulation of MAPK cascade

18190796

TgeneRARS

GO:0006420

arginyl-tRNA aminoacylation

25288775


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1418-01AWWC1chr5

167719276

+RARSchr5

167927596

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000265293ENST00000231572WWC1chr5

167719276

+RARSchr5

167927596

+
Frame-shiftENST00000265293ENST00000538719WWC1chr5

167719276

+RARSchr5

167927596

+
5CDS-3UTRENST00000265293ENST00000520421WWC1chr5

167719276

+RARSchr5

167927596

+
Frame-shiftENST00000521089ENST00000231572WWC1chr5

167719276

+RARSchr5

167927596

+
Frame-shiftENST00000521089ENST00000538719WWC1chr5

167719276

+RARSchr5

167927596

+
5CDS-3UTRENST00000521089ENST00000520421WWC1chr5

167719276

+RARSchr5

167927596

+
intron-3CDSENST00000522140ENST00000231572WWC1chr5

167719276

+RARSchr5

167927596

+
intron-3CDSENST00000522140ENST00000538719WWC1chr5

167719276

+RARSchr5

167927596

+
intron-3UTRENST00000522140ENST00000520421WWC1chr5

167719276

+RARSchr5

167927596

+

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FusionProtFeatures for WWC1_RARS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WWC1

Q8IX03

RARS

P54136

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal rolein tumor suppression by restricting proliferation and promotingapoptosis. Along with NF2 can synergistically induce thephosphorylation of LATS1 and LATS2 and can probably function inthe regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.Acts as a transcriptional coactivator of ESR1 which plays anessential role in DYNLL1-mediated ESR1 transactivation. Regulatescollagen-stimulated activation of the ERK/MAPK cascade. Modulatesdirectional migration of podocytes. Acts as a substrate for PRKCZ.Plays a role in cognition and memory performance.{ECO:0000269|PubMed:15081397, ECO:0000269|PubMed:16684779,ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123,ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598,ECO:0000269|PubMed:23778582}. Forms part of a macromolecular complex that catalyzesthe attachment of specific amino acids to cognate tRNAs duringprotein synthesis (PubMed:25288775). Modulates the secretion ofAIMP1 and may be involved in generation of the inflammatorycytokine EMAP2 from AIMP1 (PubMed:17443684).{ECO:0000269|PubMed:17443684, ECO:0000269|PubMed:25288775}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WWC1_RARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WWC1_RARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WWC1PRKCZ, CDC73, LRIF1, DLC1, HIST1H3A, FEZ1, FEZ2, LATS1, LATS2, CDC5L, TNIK, NF2, MAPK6, PTPN14, AMOT, MOV10, NXF1, PARD6B, ARRDC1, YWHAB, YWHAE, YWHAH, YWHAG, YWHAQ, ATAD3A, DYNLL1, DYNLL2, EPB41L2, EPB41L3, BTRC, FBXW11, WWC2, WWC3, PRKCA, KRAS, XPO1, TUBGCP4, PTPN21, RHPN1, TRIM25, CIT, USP9X, MPDZ, INADL, RAPGEF6, AMOTL1, MPP5, DLG1, DCTN1, MAEA, MYO1C, RMND5A, PRKCI, ARMC8, CPVL, LIN7C, DAG1, CSNK1ERARSRNPS1, EPRS, QARS, AIMP2, AIMP1, UBC, HDAC5, CUL3, CUL1, GRB2, LARS, IARS, KARS, DARS, MARS, EEF1E1, GARS, NARS, MYC, VCAM1, METTL18, EGFR, FBXO6, ASNA1, DNAJA1, EIF2S3, EIF6, HK1, CCAR2, WDR61, RPLP0, TUBB3, TUBB, STAU1, MDM2, TUBGCP2, CCDC8, RNF2, COMTD1, SDCBP, CD68, CHAT, NTRK1, PKN2, TFG, NOP56, CRY1, MCM2, NF2, C1orf131, LENG1, CDC73, CDH1, MTMR7, TARSL2, PVRL2, CCDC102B, CD93, POR, LAMP1, CYLD, DLD, DNM1L, PDHA1, SOAT1, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WWC1_RARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WWC1_RARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWWC1C0011570Mental Depression1PSYGENET
HgeneWWC1C0011581Depressive disorder1PSYGENET
HgeneWWC1C0033975Psychotic Disorders1PSYGENET
HgeneWWC1C0345967Malignant mesothelioma1CTD_human
HgeneWWC1C0349204Nonorganic psychosis1PSYGENET
TgeneRARSC4015323LEUKODYSTROPHY, HYPOMYELINATING, 91ORPHANET;UNIPROT