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Fusion gene ID: 42101 |
FusionGeneSummary for WWC1_FMN2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: WWC1_FMN2 | Fusion gene ID: 42101 | Hgene | Tgene | Gene symbol | WWC1 | FMN2 | Gene ID | 23286 | 56776 |
Gene name | WW and C2 domain containing 1 | formin 2 | |
Synonyms | HBEBP3|HBEBP36|KIBRA|MEMRYQTL|PPP1R168 | - | |
Cytomap | 5q34 | 1q43 | |
Type of gene | protein-coding | protein-coding | |
Description | protein KIBRAHBeAg-binding protein 3WW, C2 and coiled-coil domain containing 1kidney and brain proteinprotein WWC1protein phosphatase 1, regulatory subunit 168 | formin-2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8IX03 | Q9NZ56 | |
Ensembl transtripts involved in fusion gene | ENST00000265293, ENST00000521089, ENST00000522140, | ENST00000319653, ENST00000545751, ENST00000543681, ENST00000496950, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 5 X 4 X 5=100 |
# samples | 4 | 5 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: WWC1 [Title/Abstract] AND FMN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | WWC1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 24682284 |
Hgene | WWC1 | GO:0016477 | cell migration | 18596123 |
Hgene | WWC1 | GO:0035331 | negative regulation of hippo signaling | 24682284 |
Hgene | WWC1 | GO:0043410 | positive regulation of MAPK cascade | 18190796 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-2A-A8VX-01A | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000265293 | ENST00000319653 | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
5CDS-intron | ENST00000265293 | ENST00000545751 | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
5CDS-intron | ENST00000265293 | ENST00000543681 | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
5CDS-intron | ENST00000265293 | ENST00000496950 | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
Frame-shift | ENST00000521089 | ENST00000319653 | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
5CDS-intron | ENST00000521089 | ENST00000545751 | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
5CDS-intron | ENST00000521089 | ENST00000543681 | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
5CDS-intron | ENST00000521089 | ENST00000496950 | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
intron-3CDS | ENST00000522140 | ENST00000319653 | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
intron-intron | ENST00000522140 | ENST00000545751 | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
intron-intron | ENST00000522140 | ENST00000543681 | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
intron-intron | ENST00000522140 | ENST00000496950 | WWC1 | chr5 | 167798538 | + | FMN2 | chr1 | 240341221 | + |
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FusionProtFeatures for WWC1_FMN2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
WWC1 | FMN2 |
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal rolein tumor suppression by restricting proliferation and promotingapoptosis. Along with NF2 can synergistically induce thephosphorylation of LATS1 and LATS2 and can probably function inthe regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.Acts as a transcriptional coactivator of ESR1 which plays anessential role in DYNLL1-mediated ESR1 transactivation. Regulatescollagen-stimulated activation of the ERK/MAPK cascade. Modulatesdirectional migration of podocytes. Acts as a substrate for PRKCZ.Plays a role in cognition and memory performance.{ECO:0000269|PubMed:15081397, ECO:0000269|PubMed:16684779,ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123,ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598,ECO:0000269|PubMed:23778582}. | Required for asymmetric spindle positioning, asymmetricoocyte division and polar body extrusion during female germ cellmeiosis (By similarity). Actin-binding protein that is involved inactin cytoskeleton assembly and reorganization. Acts as an actinnucleation factor and promotes assembly of actin filamentstogether with SPIRE1 and SPIRE2. Involved in intracellular vesicletransport along actin fibers, providing a novel link between actincytoskeleton dynamics and intracellular transport. Plays a role inresponses to DNA damage, cellular stress and hypoxia by protectingCDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Protects cells against apoptosis byprotecting CDKN1A against degradation. {ECO:0000250,ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WWC1_FMN2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WWC1_FMN2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
WWC1 | PRKCZ, CDC73, LRIF1, DLC1, HIST1H3A, FEZ1, FEZ2, LATS1, LATS2, CDC5L, TNIK, NF2, MAPK6, PTPN14, AMOT, MOV10, NXF1, PARD6B, ARRDC1, YWHAB, YWHAE, YWHAH, YWHAG, YWHAQ, ATAD3A, DYNLL1, DYNLL2, EPB41L2, EPB41L3, BTRC, FBXW11, WWC2, WWC3, PRKCA, KRAS, XPO1, TUBGCP4, PTPN21, RHPN1, TRIM25, CIT, USP9X, MPDZ, INADL, RAPGEF6, AMOTL1, MPP5, DLG1, DCTN1, MAEA, MYO1C, RMND5A, PRKCI, ARMC8, CPVL, LIN7C, DAG1, CSNK1E | FMN2 | APBB2, TGFBR2, CASP1, BTN2A1, KPTN, BOD1, CTDSPL, ALDH3B1, SPATA5L1, PDDC1, RAB2B, PTP4A2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WWC1_FMN2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WWC1_FMN2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | WWC1 | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | WWC1 | C0011581 | Depressive disorder | 1 | PSYGENET |
Hgene | WWC1 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | WWC1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | WWC1 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Tgene | FMN2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |