	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 421

FusionGeneSummary for ACOT7_DNAJC11

Fusion gene summary

Fusion gene information	Fusion gene name: ACOT7_DNAJC11
	Fusion gene ID: 421
		Hgene	Tgene
	Gene symbol	ACOT7	DNAJC11
	Gene ID	11332	55735
	Gene name	acyl-CoA thioesterase 7	DnaJ heat shock protein family (Hsp40) member C11
	Synonyms	ACH1\|ACT\|BACH\|CTE-II\|LACH\|LACH1\|hBACH	dJ126A5.1
	Cytomap	1p36.31	1p36.31
	Type of gene	protein-coding	protein-coding
	Description	cytosolic acyl coenzyme A thioester hydrolaseCTE-IIaacyl-CoA thioesterase 2acyl-CoA thioesterase, long chainbrain acyl-CoA hydrolaselong chain acyl-CoA thioester hydrolase	dnaJ homolog subfamily C member 11DnaJ (Hsp40) homolog, subfamily C, member 11novel DnaJ domain-containing protein
	Modification date	20180523	20180523
	UniProtAcc	O00154	Q9NVH1
	Ensembl transtripts involved in fusion gene	ENST00000608083, ENST00000377855, ENST00000545482, ENST00000361521, ENST00000377842, ENST00000377845, ENST00000541130,	ENST00000465508, ENST00000349363, ENST00000377577, ENST00000294401, ENST00000542246, ENST00000377573,
Fusion gene scores	* DoF score	10 X 6 X 8=480	7 X 6 X 9=378
	# samples	12	10
	** MAII score	log2(12/480*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ACOT7 [Title/Abstract] AND DNAJC11 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ACOT7	GO:0015937	coenzyme A biosynthetic process	10578051
Hgene	ACOT7	GO:0036114	medium-chain fatty-acyl-CoA catabolic process	10578051
Hgene	ACOT7	GO:0036116	long-chain fatty-acyl-CoA catabolic process	10578051
Hgene	ACOT7	GO:0051792	medium-chain fatty acid biosynthetic process	10578051
Hgene	ACOT7	GO:1900535	palmitic acid biosynthetic process	10578051

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BLCA	TCGA-GV-A3QF-01A	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
TCGA	RV	UCS	TCGA-N8-A56S-01A	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000608083	ENST00000465508	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000608083	ENST00000349363	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000608083	ENST00000377577	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000608083	ENST00000294401	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000608083	ENST00000542246	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000608083	ENST00000377573	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377855	ENST00000465508	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377855	ENST00000349363	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377855	ENST00000377577	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377855	ENST00000294401	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377855	ENST00000542246	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377855	ENST00000377573	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000545482	ENST00000465508	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000545482	ENST00000349363	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000545482	ENST00000377577	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000545482	ENST00000294401	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000545482	ENST00000542246	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000545482	ENST00000377573	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000361521	ENST00000465508	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000361521	ENST00000349363	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000361521	ENST00000377577	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000361521	ENST00000294401	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000361521	ENST00000542246	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000361521	ENST00000377573	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377842	ENST00000465508	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377842	ENST00000349363	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377842	ENST00000377577	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377842	ENST00000294401	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377842	ENST00000542246	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377842	ENST00000377573	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377845	ENST00000465508	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377845	ENST00000349363	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377845	ENST00000377577	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377845	ENST00000294401	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377845	ENST00000542246	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377845	ENST00000377573	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000541130	ENST00000465508	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000541130	ENST00000349363	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000541130	ENST00000377577	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000541130	ENST00000294401	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000541130	ENST00000542246	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000541130	ENST00000377573	ACOT7	chr1	6378552	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000608083	ENST00000465508	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000608083	ENST00000349363	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000608083	ENST00000377577	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000608083	ENST00000294401	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000608083	ENST00000542246	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000608083	ENST00000377573	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377855	ENST00000465508	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377855	ENST00000349363	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377855	ENST00000377577	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377855	ENST00000294401	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377855	ENST00000542246	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377855	ENST00000377573	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000545482	ENST00000465508	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000545482	ENST00000349363	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000545482	ENST00000377577	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000545482	ENST00000294401	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000545482	ENST00000542246	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000545482	ENST00000377573	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000361521	ENST00000465508	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000361521	ENST00000349363	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000361521	ENST00000377577	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000361521	ENST00000294401	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000361521	ENST00000542246	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000361521	ENST00000377573	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377842	ENST00000465508	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377842	ENST00000349363	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377842	ENST00000377577	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377842	ENST00000294401	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377842	ENST00000542246	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377842	ENST00000377573	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377845	ENST00000465508	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377845	ENST00000349363	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377845	ENST00000377577	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377845	ENST00000294401	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377845	ENST00000542246	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
5CDS-intron	ENST00000377845	ENST00000377573	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
intron-intron	ENST00000541130	ENST00000465508	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
intron-intron	ENST00000541130	ENST00000349363	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
intron-intron	ENST00000541130	ENST00000377577	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
intron-intron	ENST00000541130	ENST00000294401	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
intron-intron	ENST00000541130	ENST00000542246	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-
intron-intron	ENST00000541130	ENST00000377573	ACOT7	chr1	6341162	-	DNAJC11	chr1	6727870	-

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FusionProtFeatures for ACOT7_DNAJC11

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ACOT7 O00154	DNAJC11 Q9NVH1
	Isoform 1: Required for mitochondrial inner membraneorganization. Seems to function through its association with theMICOS complex and the mitochondrial outer membrane sortingassembly machinery (SAM) complex. {ECO:0000269\|PubMed:25111180,ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ACOT7_DNAJC11

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACOT7_DNAJC11

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
ACOT7	TERF1, TINF2, POT1, CDK2, ATXN1, ATXN1L, GDI1, NDRG1, NHLRC2, TNFAIP8, ALDH9A1, GAPDH, PDIA3, RCC2, SORD, CAMK2B, CRYAB, MAGEA6, UBQLN1, THAP1, DHRS4L2, CAB39L, RELT, PCBP1, NTRK1, FOXI2, ATP5A1, PHYHIPL, DUSP19, DUSP4, BTRC, PKNOX1, RABGAP1L, HSD17B10, SOD1, LMNA	DNAJC11	MINOS1, RPS6KA5, FBXO6, LATS1, PPP6R3, EGFR, RIC3, ARMC1, MCOLN3, SYNE4, TRABD, ERGIC3, HEPACAM2, NTRK1, MKS1, TCTN3, XPO1, ANXA7, CAPG, H3F3A, INPP5B, PRICKLE3, RBM4, STXBP1, TBX3, TRAP1, HAX1, IMMT, PITPNB, BCOR, CHCHD3, GOLT1B, RBM26, CD99L2, RNF214, H3F3C, APOOL, C19orf70, SUOX, PDE6D, FAM174A, WDR73, YTHDF1, TAX1BP1, ZNHIT2, TRIM25

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ACOT7_DNAJC11

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ACOT7_DNAJC11

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 421

FusionGeneSummary for ACOT7_DNAJC11

FusionProtFeatures for ACOT7_DNAJC11

FusionGeneSequence for ACOT7_DNAJC11

FusionGenePPI for ACOT7_DNAJC11

RelatedDrugs for ACOT7_DNAJC11

RelatedDiseases for ACOT7_DNAJC11