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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42093

FusionGeneSummary for WT1-AS_SLC1A2

check button Fusion gene summary
Fusion gene informationFusion gene name: WT1-AS_SLC1A2
Fusion gene ID: 42093
HgeneTgene
Gene symbol

WT1-AS

SLC1A2

Gene ID

51352

6506

Gene nameWT1 antisense RNAsolute carrier family 1 member 2
SynonymsWIT-1|WIT1|WT1-AS1|WT1ASEAAT2|EIEE41|GLT-1|HBGT
Cytomap

11p13

11p13

Type of genencRNAprotein-coding
DescriptionWT1 antisense RNA (non-protein coding)Wilms tumor associated proteinWilms tumor upstream neighbor 1excitatory amino acid transporter 2excitotoxic amino acid transporter 2glutamate/aspartate transporter IIsodium-dependent glutamate/aspartate transporter 2solute carrier family 1 (glial high affinity glutamate transporter), member 2
Modification date2018051920180519
UniProtAcc

P43004

Ensembl transtripts involved in fusion geneENST00000494911, ENST00000395900, 
ENST00000459866, ENST00000525436, 
ENST00000478367, ENST00000426618, 
ENST00000442957, 
ENST00000278379, 
ENST00000395750, ENST00000395753, 
ENST00000606205, ENST00000479543, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 8 X 5=360
# samples 111
** MAII scorelog2(1/1*10)=3.32192809488736log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WT1-AS [Title/Abstract] AND SLC1A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC1A2

GO:0015813

L-glutamate transmembrane transport

26690923

TgeneSLC1A2

GO:0070207

protein homotrimerization

15265858|15483603

TgeneSLC1A2

GO:0070779

D-aspartate import across plasma membrane

7521911

TgeneSLC1A2

GO:0098712

L-glutamate import across plasma membrane

7521911|15265858|26690923


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-GI-A2C8-01AWT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000494911ENST00000278379WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-5UTRENST00000494911ENST00000395750WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-5UTRENST00000494911ENST00000395753WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-5UTRENST00000494911ENST00000606205WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-intronENST00000494911ENST00000479543WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-3CDSENST00000395900ENST00000278379WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-5UTRENST00000395900ENST00000395750WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-5UTRENST00000395900ENST00000395753WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-5UTRENST00000395900ENST00000606205WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-intronENST00000395900ENST00000479543WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-3CDSENST00000459866ENST00000278379WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-5UTRENST00000459866ENST00000395750WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-5UTRENST00000459866ENST00000395753WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-5UTRENST00000459866ENST00000606205WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-intronENST00000459866ENST00000479543WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-3CDSENST00000525436ENST00000278379WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-5UTRENST00000525436ENST00000395750WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-5UTRENST00000525436ENST00000395753WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-5UTRENST00000525436ENST00000606205WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
3UTR-intronENST00000525436ENST00000479543WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-3CDSENST00000478367ENST00000278379WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-5UTRENST00000478367ENST00000395750WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-5UTRENST00000478367ENST00000395753WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-5UTRENST00000478367ENST00000606205WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-intronENST00000478367ENST00000479543WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-3CDSENST00000426618ENST00000278379WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-5UTRENST00000426618ENST00000395750WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-5UTRENST00000426618ENST00000395753WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-5UTRENST00000426618ENST00000606205WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-intronENST00000426618ENST00000479543WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-3CDSENST00000442957ENST00000278379WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-5UTRENST00000442957ENST00000395750WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-5UTRENST00000442957ENST00000395753WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-5UTRENST00000442957ENST00000606205WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-
intron-intronENST00000442957ENST00000479543WT1-ASchr11

32457392

+SLC1A2chr11

35339063

-

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FusionProtFeatures for WT1-AS_SLC1A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WT1-AS

SLC1A2

P43004

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Sodium-dependent, high-affinity amino acid transporterthat mediates the uptake of L-glutamate and also L-aspartate andD-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858,PubMed:26690923). Functions as a symporter that transports oneamino acid molecule together with two or three Na(+) ions and oneproton, in parallel with the counter-transport of one K(+) ion(PubMed:14506254). Mediates Cl(-) flux that is not coupled toamino acid transport; this avoids the accumulation of negativecharges due to aspartate and Na(+) symport (PubMed:14506254).Essential for the rapid removal of released glutamate from thesynaptic cleft, and for terminating the postsynaptic action ofglutamate (By similarity). {ECO:0000250|UniProtKB:P43006,ECO:0000269|PubMed:15265858, ECO:0000269|PubMed:26690923,ECO:0000269|PubMed:7521911}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WT1-AS_SLC1A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WT1-AS_SLC1A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WT1-ASTRIM27, TRIP6, PNMA1, TMCC2, MID2, LZTS2, KRT40, KRTAP10-9, KRTAP10-5, KRTAP10-8, NOTCH2NLSLC1A2AJUBA, GRB2, PML, MAPT, RPL17, RPL23A, RPL32, RPL38, RPL5, RPL3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WT1-AS_SLC1A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC1A2P43004DB00142Glutamic AcidExcitatory amino acid transporter 2small moleculeapproved|nutraceutical

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RelatedDiseases for WT1-AS_SLC1A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC1A2C0005586Bipolar Disorder4PSYGENET
TgeneSLC1A2C0036341Schizophrenia4PSYGENET
TgeneSLC1A2C0001973Alcoholic Intoxication, Chronic3PSYGENET
TgeneSLC1A2C0011570Mental Depression3PSYGENET
TgeneSLC1A2C0011581Depressive disorder3PSYGENET
TgeneSLC1A2C0002736Amyotrophic Lateral Sclerosis1CTD_human
TgeneSLC1A2C0014544Epilepsy1CTD_human
TgeneSLC1A2C0027746Nerve Degeneration1CTD_human
TgeneSLC1A2C0038356Stomach Neoplasms1CTD_human
TgeneSLC1A2C0236736Cocaine-Related Disorders1CTD_human
TgeneSLC1A2C0525045Mood Disorders1PSYGENET