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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42088

FusionGeneSummary for WSB2_RFC5

check button Fusion gene summary
Fusion gene informationFusion gene name: WSB2_RFC5
Fusion gene ID: 42088
HgeneTgene
Gene symbol

WSB2

RFC5

Gene ID

55884

5985

Gene nameWD repeat and SOCS box containing 2replication factor C subunit 5
SynonymsSBA2RFC36
Cytomap

12q24.23

12q24.23

Type of geneprotein-codingprotein-coding
DescriptionWD repeat and SOCS box-containing protein 2CS box-containing WD proteinWSB-2replication factor C subunit 5A1 36 kDa subunitRF-C 36 kDa subunitRFC, 36.5 kD subunitreplication factor C (activator 1) 5, 36.5kDareplication factor C, 36-kDa subunit
Modification date2018051920180523
UniProtAcc

Q9NYS7

P40937

Ensembl transtripts involved in fusion geneENST00000315436, ENST00000542304, 
ENST00000441406, ENST00000544233, 
ENST00000535496, ENST00000536738, 
ENST00000229043, ENST00000454402, 
ENST00000392542, ENST00000543153, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 3=27
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WSB2 [Title/Abstract] AND RFC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRFC5

GO:1900264

positive regulation of DNA-directed DNA polymerase activity

12930902


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-91-7771-01AWSB2chr12

118480646

-RFC5chr12

118467576

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000315436ENST00000229043WSB2chr12

118480646

-RFC5chr12

118467576

+
In-frameENST00000315436ENST00000454402WSB2chr12

118480646

-RFC5chr12

118467576

+
In-frameENST00000315436ENST00000392542WSB2chr12

118480646

-RFC5chr12

118467576

+
5CDS-3UTRENST00000315436ENST00000543153WSB2chr12

118480646

-RFC5chr12

118467576

+
5UTR-3CDSENST00000542304ENST00000229043WSB2chr12

118480646

-RFC5chr12

118467576

+
5UTR-3CDSENST00000542304ENST00000454402WSB2chr12

118480646

-RFC5chr12

118467576

+
5UTR-3CDSENST00000542304ENST00000392542WSB2chr12

118480646

-RFC5chr12

118467576

+
5UTR-3UTRENST00000542304ENST00000543153WSB2chr12

118480646

-RFC5chr12

118467576

+
In-frameENST00000441406ENST00000229043WSB2chr12

118480646

-RFC5chr12

118467576

+
In-frameENST00000441406ENST00000454402WSB2chr12

118480646

-RFC5chr12

118467576

+
In-frameENST00000441406ENST00000392542WSB2chr12

118480646

-RFC5chr12

118467576

+
5CDS-3UTRENST00000441406ENST00000543153WSB2chr12

118480646

-RFC5chr12

118467576

+
intron-3CDSENST00000544233ENST00000229043WSB2chr12

118480646

-RFC5chr12

118467576

+
intron-3CDSENST00000544233ENST00000454402WSB2chr12

118480646

-RFC5chr12

118467576

+
intron-3CDSENST00000544233ENST00000392542WSB2chr12

118480646

-RFC5chr12

118467576

+
intron-3UTRENST00000544233ENST00000543153WSB2chr12

118480646

-RFC5chr12

118467576

+
In-frameENST00000535496ENST00000229043WSB2chr12

118480646

-RFC5chr12

118467576

+
In-frameENST00000535496ENST00000454402WSB2chr12

118480646

-RFC5chr12

118467576

+
In-frameENST00000535496ENST00000392542WSB2chr12

118480646

-RFC5chr12

118467576

+
5CDS-3UTRENST00000535496ENST00000543153WSB2chr12

118480646

-RFC5chr12

118467576

+
5UTR-3CDSENST00000536738ENST00000229043WSB2chr12

118480646

-RFC5chr12

118467576

+
5UTR-3CDSENST00000536738ENST00000454402WSB2chr12

118480646

-RFC5chr12

118467576

+
5UTR-3CDSENST00000536738ENST00000392542WSB2chr12

118480646

-RFC5chr12

118467576

+
5UTR-3UTRENST00000536738ENST00000543153WSB2chr12

118480646

-RFC5chr12

118467576

+

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FusionProtFeatures for WSB2_RFC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WSB2

Q9NYS7

RFC5

P40937

May be a substrate-recognition component of a SCF-likeECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complexwhich mediates the ubiquitination and subsequent proteasomaldegradation of target proteins. {ECO:0000250}. The elongation of primed DNA templates by DNA polymerasedelta and epsilon requires the action of the accessory proteinsproliferating cell nuclear antigen (PCNA) and activator 1.{ECO:0000269|PubMed:8999859}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWSB2chr12:118480646chr12:118467576ENST00000315436-49144_183186405RepeatNote=WD 3
HgeneWSB2chr12:118480646chr12:118467576ENST00000315436-4916_55186405RepeatNote=WD 1
HgeneWSB2chr12:118480646chr12:118467576ENST00000315436-4981_140186405RepeatNote=WD 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWSB2chr12:118480646chr12:118467576ENST00000315436-49356_404186405DomainSOCS box
HgeneWSB2chr12:118480646chr12:118467576ENST00000315436-49188_226186405RepeatNote=WD 4
HgeneWSB2chr12:118480646chr12:118467576ENST00000315436-49230_268186405RepeatNote=WD 5
HgeneWSB2chr12:118480646chr12:118467576ENST00000315436-49283_322186405RepeatNote=WD 6
HgeneWSB2chr12:118480646chr12:118467576ENST00000315436-49325_362186405RepeatNote=WD 7
TgeneRFC5chr12:118480646chr12:118467576ENST00000392542+91260_67269320Nucleotide bindingATP
TgeneRFC5chr12:118480646chr12:118467576ENST00000454402+81160_67290341Nucleotide bindingATP


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FusionGeneSequence for WSB2_RFC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WSB2_RFC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WSB2EZH2, CSF3R, ELAVL1, DDB1, CUL4A, CUL5, IL21R, HSP90AA1, SNIP1, CLASRP, ACIN1, CCDC9, ZC3H14, ARIH2, C17orf85, UBB, PNN, ISY1, RNPS1, NKTR, AMBRA1, SUPT6H, DDA1RFC5RFC4, CD40, RAD17, CHTF18, MED31, COPS6, RBM48, EEF1A1, LRIF1, UNC119, BRD4, RFC2, PCNA, RFC1, RUVBL2, RPAP3, MEPCE, UBC, MYC, PIDD1, SMARCAD1, HDGF, CUL3, CAND1, RFC3, MTMR2, ECT2, MDC1, VCP, MMS19, FBXO6, RPA1, RPA2, RPA3, HUWE1, XIAP, NAB2, TRIM38, CCDC8, EED, EGFR, DSCC1, GTF2B, NMD3, PSMC4, NTRK1, OFD1, MKS1, SPICE1, CENPJ, HNRNPU, RPL10, NOP56, SNW1, CDC5L, NFATC1, NFATC2, ZNF746, ATAD5, CHTF8, RB1, IL13RA2, MCM9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WSB2_RFC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WSB2_RFC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource