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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42079

FusionGeneSummary for WRN_NRG1

check button Fusion gene summary
Fusion gene informationFusion gene name: WRN_NRG1
Fusion gene ID: 42079
HgeneTgene
Gene symbol

WRN

NRG1

Gene ID

7486

3084

Gene nameWerner syndrome RecQ like helicaseneuregulin 1
SynonymsRECQ3|RECQL2|RECQL3ARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDF
Cytomap

8p12

8p12

Type of geneprotein-codingprotein-coding
DescriptionWerner syndrome ATP-dependent helicaseDNA helicase, RecQ-like type 3Werner syndrome, RecQ helicase-likeexonuclease WRNrecQ protein-like 2pro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factor
Modification date2018052320180523
UniProtAcc

Q14191

Q02297

Ensembl transtripts involved in fusion geneENST00000298139, ENST00000519301, 
ENST00000520407, ENST00000523079, 
ENST00000338921, ENST00000356819, 
ENST00000287845, ENST00000341377, 
ENST00000287842, ENST00000521670, 
ENST00000405005, ENST00000520502, 
ENST00000539990, ENST00000523681, 
Fusion gene scores* DoF score4 X 4 X 4=6416 X 6 X 11=1056
# samples 416
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/1056*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WRN [Title/Abstract] AND NRG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWRN

GO:0000731

DNA synthesis involved in DNA repair

17563354

HgeneWRN

GO:0006259

DNA metabolic process

16622405

HgeneWRN

GO:0006284

base-excision repair

17611195

HgeneWRN

GO:0006974

cellular response to DNA damage stimulus

18203716

HgeneWRN

GO:0006979

response to oxidative stress

17611195

HgeneWRN

GO:0009267

cellular response to starvation

11420665

HgeneWRN

GO:0010225

response to UV-C

17563354

HgeneWRN

GO:0031297

replication fork processing

17115688

HgeneWRN

GO:0032508

DNA duplex unwinding

11735402|26420422

HgeneWRN

GO:0044806

G-quadruplex DNA unwinding

11735402

HgeneWRN

GO:0051345

positive regulation of hydrolase activity

17611195

HgeneWRN

GO:0061820

telomeric D-loop disassembly

15200954|19734539|26420422

HgeneWRN

GO:0071480

cellular response to gamma radiation

21639834

HgeneWRN

GO:0098530

positive regulation of strand invasion

26420422

HgeneWRN

GO:1902570

protein localization to nucleolus

11420665

TgeneNRG1

GO:0003222

ventricular trabecula myocardium morphogenesis

17336907

TgeneNRG1

GO:0038127

ERBB signaling pathway

11389077

TgeneNRG1

GO:0038129

ERBB3 signaling pathway

27353365

TgeneNRG1

GO:0043497

regulation of protein heterodimerization activity

10559227

TgeneNRG1

GO:0045892

negative regulation of transcription, DNA-templated

15073182

TgeneNRG1

GO:0051048

negative regulation of secretion

10559227

TgeneNRG1

GO:0060379

cardiac muscle cell myoblast differentiation

17336907

TgeneNRG1

GO:0060956

endocardial cell differentiation

17336907


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-AAD0-01AWRNchr8

31024746

+NRG1chr8

32585467

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000298139ENST00000519301WRNchr8

31024746

+NRG1chr8

32585467

+
Frame-shitENST00000298139ENST00000520407WRNchr8

31024746

+NRG1chr8

32585467

+
Frame-shitENST00000298139ENST00000523079WRNchr8

31024746

+NRG1chr8

32585467

+
Frame-shitENST00000298139ENST00000338921WRNchr8

31024746

+NRG1chr8

32585467

+
Frame-shitENST00000298139ENST00000356819WRNchr8

31024746

+NRG1chr8

32585467

+
Frame-shitENST00000298139ENST00000287845WRNchr8

31024746

+NRG1chr8

32585467

+
Frame-shitENST00000298139ENST00000341377WRNchr8

31024746

+NRG1chr8

32585467

+
Frame-shitENST00000298139ENST00000287842WRNchr8

31024746

+NRG1chr8

32585467

+
Frame-shitENST00000298139ENST00000521670WRNchr8

31024746

+NRG1chr8

32585467

+
Frame-shitENST00000298139ENST00000405005WRNchr8

31024746

+NRG1chr8

32585467

+
Frame-shitENST00000298139ENST00000520502WRNchr8

31024746

+NRG1chr8

32585467

+
Frame-shitENST00000298139ENST00000539990WRNchr8

31024746

+NRG1chr8

32585467

+
5CDS-intronENST00000298139ENST00000523681WRNchr8

31024746

+NRG1chr8

32585467

+

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FusionProtFeatures for WRN_NRG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WRN

Q14191

NRG1

Q02297

Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activitytowards double-stranded DNA with a 5'-overhang. Has no nucleaseactivity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containingalternate secondary structures, such as replication forks andHolliday junctions. May play an important role in the dissociationof joint DNA molecules that can arise as products of homologousrecombination, at stalled replication forks or during DNA repair.Alleviates stalling of DNA polymerases at the site of DNA lesions.Important for genomic integrity. Plays a role in the formation ofDNA replication focal centers; stably associates with focielements generating binding sites for RP-A (By similarity). Playsa role in double-strand break repair after gamma-irradiation.{ECO:0000250, ECO:0000269|PubMed:11863428,ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042,ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551,ECO:0000269|PubMed:21639834}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WRN_NRG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WRN_NRG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WRNMDC1, TERF2, BLM, ATM, ATR, PRKDC, FEN1, PCNA, WRNIP1, POLR1C, XRCC5, XRCC6, TP53, WDR48, CHAF1A, POLB, POT1, H2AFX, NBN, DHX9, RAD51, RAD52, ATRX, RAD54B, SIRT1, WRN, PARP1, VCP, CDKN2A, CDC5L, PML, SUMO1, SUMO2, RPA1, RPA2, RPA3, CREBBP, KIAA0930, SKAP1, NTRK1, MUS81, PTTG1, TINF2, POLK, POLL, SUPT16H, ARL3, CHEK2, CHEK1, WEE1, TUBA1ANRG1LIMK1, ERBB3, ERBB2, EGFR, ERBB4, MBOAT7, LSR, PGAP1, KIAA2013, SREBF2, LEMD3, TMTC3, TMTC4, POMGNT2, SLC38A10, ATP7B, SLC35B2, NDUFA3, ZDHHC17, TMEM39B, DNAAF5, B3GNT2, RHOBTB3, CISD2, POMT1, SPTLC2, SLC25A16, RDH11, MGAT1, HMOX1, KIAA1467, EXTL3, SLC25A23, NETO2, LPHN1, CNTNAP3, HLA-DPB1, UQCRQ, GLMN, DEGS1, TMEM63B, DDX11L8, ABCB10, GYLTL1B, B3GALNT2, TMEM181, INTS7, MYO19, GALNT11, C1GALT1C1, SLC22A18, NEK4, ABCA3, TMEM164, MTCH1, OPA3, HS6ST1, SFXN3, TM2D3, DSE, TMEM205, RNF130, PIGU, CDC5L, LGR4, TUBB3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WRN_NRG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WRN_NRG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWRNC0043119Werner Syndrome3CTD_human;ORPHANET;UNIPROT
HgeneWRNC0231341Premature aging syndrome1CTD_human
TgeneNRG1C0036341Schizophrenia7CTD_human
TgeneNRG1C0005586Bipolar Disorder5PSYGENET
TgeneNRG1C0024809Marijuana Abuse3PSYGENET
TgeneNRG1C0011570Mental Depression2PSYGENET
TgeneNRG1C0011581Depressive disorder2PSYGENET
TgeneNRG1C0006870Cannabis Dependence1PSYGENET
TgeneNRG1C0007621Neoplastic Cell Transformation1CTD_human
TgeneNRG1C0011616Contact Dermatitis1CTD_human
TgeneNRG1C0018801Heart failure1CTD_human
TgeneNRG1C0019569Hirschsprung Disease1CTD_human
TgeneNRG1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneNRG1C0026650Movement Disorders1CTD_human
TgeneNRG1C0027626Neoplasm Invasiveness1CTD_human
TgeneNRG1C0030193Pain1CTD_human
TgeneNRG1C0032460Polycystic Ovary Syndrome1CTD_human
TgeneNRG1C0033937Psychoses, Drug1PSYGENET
TgeneNRG1C0038358Gastric ulcer1CTD_human
TgeneNRG1C0236733Amphetamine-Related Disorders1CTD_human
TgeneNRG1C1458155Mammary Neoplasms1CTD_human
TgeneNRG1C3495559Juvenile arthritis1CTD_human