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Fusion gene ID: 42078 |
FusionGeneSummary for WRN_LETM2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WRN_LETM2 | Fusion gene ID: 42078 | Hgene | Tgene | Gene symbol | WRN | LETM2 | Gene ID | 7486 | 137994 |
| Gene name | Werner syndrome RecQ like helicase | leucine zipper and EF-hand containing transmembrane protein 2 | |
| Synonyms | RECQ3|RECQL2|RECQL3 | SLC55A2 | |
| Cytomap | 8p12 | 8p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Werner syndrome ATP-dependent helicaseDNA helicase, RecQ-like type 3Werner syndrome, RecQ helicase-likeexonuclease WRNrecQ protein-like 2 | LETM1 domain-containing protein LETM2, mitochondrialLETM1 and EF-hand domain-containing protein 2leucine zipper-EF-hand containing transmembrane protein 1-like proteinleucine zipper-EF-hand containing transmembrane protein 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q14191 | Q2VYF4 | |
| Ensembl transtripts involved in fusion gene | ENST00000298139, | ENST00000519476, ENST00000297720, ENST00000524874, ENST00000379957, ENST00000523983, ENST00000527710, ENST00000528827, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 11 X 3 X 7=231 |
| # samples | 4 | 11 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/231*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: WRN [Title/Abstract] AND LETM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | WRN | GO:0000731 | DNA synthesis involved in DNA repair | 17563354 |
| Hgene | WRN | GO:0006259 | DNA metabolic process | 16622405 |
| Hgene | WRN | GO:0006284 | base-excision repair | 17611195 |
| Hgene | WRN | GO:0006974 | cellular response to DNA damage stimulus | 18203716 |
| Hgene | WRN | GO:0006979 | response to oxidative stress | 17611195 |
| Hgene | WRN | GO:0009267 | cellular response to starvation | 11420665 |
| Hgene | WRN | GO:0010225 | response to UV-C | 17563354 |
| Hgene | WRN | GO:0031297 | replication fork processing | 17115688 |
| Hgene | WRN | GO:0032508 | DNA duplex unwinding | 11735402|26420422 |
| Hgene | WRN | GO:0044806 | G-quadruplex DNA unwinding | 11735402 |
| Hgene | WRN | GO:0051345 | positive regulation of hydrolase activity | 17611195 |
| Hgene | WRN | GO:0061820 | telomeric D-loop disassembly | 15200954|19734539|26420422 |
| Hgene | WRN | GO:0071480 | cellular response to gamma radiation | 21639834 |
| Hgene | WRN | GO:0098530 | positive regulation of strand invasion | 26420422 |
| Hgene | WRN | GO:1902570 | protein localization to nucleolus | 11420665 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCS | TCGA-N5-A4RO-01A | WRN | chr8 | 30891489 | + | LETM2 | chr8 | 38245468 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000298139 | ENST00000519476 | WRN | chr8 | 30891489 | + | LETM2 | chr8 | 38245468 | + |
| 5UTR-5UTR | ENST00000298139 | ENST00000297720 | WRN | chr8 | 30891489 | + | LETM2 | chr8 | 38245468 | + |
| 5UTR-5UTR | ENST00000298139 | ENST00000524874 | WRN | chr8 | 30891489 | + | LETM2 | chr8 | 38245468 | + |
| 5UTR-5UTR | ENST00000298139 | ENST00000379957 | WRN | chr8 | 30891489 | + | LETM2 | chr8 | 38245468 | + |
| 5UTR-5UTR | ENST00000298139 | ENST00000523983 | WRN | chr8 | 30891489 | + | LETM2 | chr8 | 38245468 | + |
| 5UTR-intron | ENST00000298139 | ENST00000527710 | WRN | chr8 | 30891489 | + | LETM2 | chr8 | 38245468 | + |
| 5UTR-intron | ENST00000298139 | ENST00000528827 | WRN | chr8 | 30891489 | + | LETM2 | chr8 | 38245468 | + |
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FusionProtFeatures for WRN_LETM2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WRN | LETM2 |
| Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activitytowards double-stranded DNA with a 5'-overhang. Has no nucleaseactivity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containingalternate secondary structures, such as replication forks andHolliday junctions. May play an important role in the dissociationof joint DNA molecules that can arise as products of homologousrecombination, at stalled replication forks or during DNA repair.Alleviates stalling of DNA polymerases at the site of DNA lesions.Important for genomic integrity. Plays a role in the formation ofDNA replication focal centers; stably associates with focielements generating binding sites for RP-A (By similarity). Playsa role in double-strand break repair after gamma-irradiation.{ECO:0000250, ECO:0000269|PubMed:11863428,ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042,ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551,ECO:0000269|PubMed:21639834}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WRN_LETM2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WRN_LETM2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| WRN | MDC1, TERF2, BLM, ATM, ATR, PRKDC, FEN1, PCNA, WRNIP1, POLR1C, XRCC5, XRCC6, TP53, WDR48, CHAF1A, POLB, POT1, H2AFX, NBN, DHX9, RAD51, RAD52, ATRX, RAD54B, SIRT1, WRN, PARP1, VCP, CDKN2A, CDC5L, PML, SUMO1, SUMO2, RPA1, RPA2, RPA3, CREBBP, KIAA0930, SKAP1, NTRK1, MUS81, PTTG1, TINF2, POLK, POLL, SUPT16H, ARL3, CHEK2, CHEK1, WEE1, TUBA1A | LETM2 | APP, FBXW7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WRN_LETM2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WRN_LETM2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | WRN | C0043119 | Werner Syndrome | 3 | CTD_human;ORPHANET;UNIPROT |
| Hgene | WRN | C0231341 | Premature aging syndrome | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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