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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42067

FusionGeneSummary for WRAP53_AHCY

check button Fusion gene summary
Fusion gene informationFusion gene name: WRAP53_AHCY
Fusion gene ID: 42067
HgeneTgene
Gene symbol

WRAP53

AHCY

Gene ID

55135

191

Gene nameWD repeat containing antisense to TP53adenosylhomocysteinase
SynonymsDKCB3|TCAB1|WDR79SAHH|adoHcyase
Cytomap

17p13.1

20q11.22

Type of geneprotein-codingprotein-coding
Descriptiontelomerase Cajal body protein 1WD repeat-containing protein 79WD repeat-containing protein WRAP53WD40 protein Wrap53WD40 repeat-containing protein antisense to TP53WD40 repeat-containing protein encoding RNA antisense to p53adenosylhomocysteinaseS-adenosyl-L-homocysteine hydrolaseS-adenosylhomocysteine hydrolase
Modification date2018051920180523
UniProtAcc

Q9BUR4

P23526

Ensembl transtripts involved in fusion geneENST00000431639, ENST00000316024, 
ENST00000457584, ENST00000396463, 
ENST00000534050, 
ENST00000538132, 
ENST00000217426, ENST00000468908, 
Fusion gene scores* DoF score4 X 3 X 4=486 X 3 X 6=108
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WRAP53 [Title/Abstract] AND AHCY [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWRAP53

GO:0007004

telomere maintenance via telomerase

23685356

HgeneWRAP53

GO:0051973

positive regulation of telomerase activity

19179534|23685356


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-OR-A5LO-01AWRAP53chr17

7593019

+AHCYchr20

32868971

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000431639ENST00000538132WRAP53chr17

7593019

+AHCYchr20

32868971

-
Frame-shitENST00000431639ENST00000217426WRAP53chr17

7593019

+AHCYchr20

32868971

-
5CDS-intronENST00000431639ENST00000468908WRAP53chr17

7593019

+AHCYchr20

32868971

-
Frame-shitENST00000316024ENST00000538132WRAP53chr17

7593019

+AHCYchr20

32868971

-
Frame-shitENST00000316024ENST00000217426WRAP53chr17

7593019

+AHCYchr20

32868971

-
5CDS-intronENST00000316024ENST00000468908WRAP53chr17

7593019

+AHCYchr20

32868971

-
Frame-shitENST00000457584ENST00000538132WRAP53chr17

7593019

+AHCYchr20

32868971

-
Frame-shitENST00000457584ENST00000217426WRAP53chr17

7593019

+AHCYchr20

32868971

-
5CDS-intronENST00000457584ENST00000468908WRAP53chr17

7593019

+AHCYchr20

32868971

-
Frame-shitENST00000396463ENST00000538132WRAP53chr17

7593019

+AHCYchr20

32868971

-
Frame-shitENST00000396463ENST00000217426WRAP53chr17

7593019

+AHCYchr20

32868971

-
5CDS-intronENST00000396463ENST00000468908WRAP53chr17

7593019

+AHCYchr20

32868971

-
Frame-shitENST00000534050ENST00000538132WRAP53chr17

7593019

+AHCYchr20

32868971

-
Frame-shitENST00000534050ENST00000217426WRAP53chr17

7593019

+AHCYchr20

32868971

-
5CDS-intronENST00000534050ENST00000468908WRAP53chr17

7593019

+AHCYchr20

32868971

-

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FusionProtFeatures for WRAP53_AHCY


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WRAP53

Q9BUR4

AHCY

P23526

Essential component of the telomerase holoenzymecomplex, a ribonucleoprotein complex essential for the replicationof chromosome termini that elongates telomeres in most eukaryotes.In the telomerase holoenzyme complex, it controls telomeraselocalization to Cajal body. Required for delivery of TERC totelomeres during S phase and for telomerase activity. Binds smallCajal body RNAs (scaRNAs). The mRNA encoding this protein plays acritical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basalp53 mRNA levels and in p53 induction upon DNA damage.{ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19250907}. Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions;therefore adenosylhomocysteinase may play a key role in thecontrol of methylations via regulation of the intracellularconcentration of adenosylhomocysteine.{ECO:0000269|PubMed:12590576}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WRAP53_AHCY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WRAP53_AHCY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WRAP53PRPF4, PTGES3, XPC, WAPAL, SNRPC, USP11, TNPO1, RBBP7, GAR1, FAM43A, MDC1, RNF8, H2AFX, HNRNPU, ZFHX3, CCT6A, DKC1, MYBPH, NDUFV3, TCP1, CCT3, STK24, CCT7, CCT4, CCT2, CCT8, CCT5, PRPF38B, PTPN1, RAP1B, RXRB, POLG2, CNTROB, MRPL14, KIAA1683, LYPD4, CRYL1, ARHGAP25, FAM46AAHCYHLA-B, PINX1, TP73, HDAC5, TERF1, POT1, CUL3, CUL4B, CDK2, CUL1, COPS5, CAND1, NEDD8, XIAP, SDC1, GMPS, SERPINB6, SIRT1, ATP6V1A, TRAF3IP1, ATF2, DAB2, PXN, YWHAQ, FBXO6, HECW2, ACAT2, FH, HEXA, HK1, OGFOD1, UBA3, ATIC, CAPZB, DHX15, EEF1A2, H2AFV, HDGF, MC1R, MSN, NSFL1C, PAPSS1, PYGL, TBCE, ASB16, HUWE1, FUS, AHCY, APPBP2, C1orf50, ANKRD40, CUL7, AHCYL1, LGALS3, ALDH4A1, GPT2, HSPB1, LDHB, NME1-NME2, NME2, TLE3, NTRK1, EWSR1, CEP104, CEP290, NIN, EVC2, FOS, FOXK1, MCM2, DERL1, DNM1L, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WRAP53_AHCY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneAHCYP23526DB02325Isopropyl AlcoholAdenosylhomocysteinasesmall moleculeapproved|investigational

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RelatedDiseases for WRAP53_AHCY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWRAP53C3151442DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE, 31UNIPROT
TgeneAHCYC3151058Hypermethioninemia with Deficiency of S-Adenosylhomocysteine Hydrolase2ORPHANET;UNIPROT
TgeneAHCYC0002514Amino Acid Metabolism, Inborn Errors1CTD_human
TgeneAHCYC0019202Hepatolenticular Degeneration1CTD_human
TgeneAHCYC0242184Hypoxia1CTD_human
TgeneAHCYC4048705Hypermethioninemia1CTD_human