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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42064

FusionGeneSummary for WNT7B_DGCR8

check button Fusion gene summary
Fusion gene informationFusion gene name: WNT7B_DGCR8
Fusion gene ID: 42064
HgeneTgene
Gene symbol

WNT7B

DGCR8

Gene ID

7477

54487

Gene nameWnt family member 7BDGCR8, microprocessor complex subunit
Synonyms-C22orf12|DGCRK6|Gy1|pasha
Cytomap

22q13.31

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionprotein Wnt-7bwingless-type MMTV integration site family, member 7Bmicroprocessor complex subunit DGCR8DiGeorge syndrome critical region 8DiGeorge syndrome critical region gene 8
Modification date2018052320180522
UniProtAcc

P56706

Q8WYQ5

Ensembl transtripts involved in fusion geneENST00000339464, ENST00000409496, 
ENST00000410089, ENST00000410058, 
ENST00000351989, ENST00000383024, 
ENST00000407755, 
Fusion gene scores* DoF score2 X 3 X 2=126 X 5 X 4=120
# samples 28
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WNT7B [Title/Abstract] AND DGCR8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWNT7B

GO:0060070

canonical Wnt signaling pathway

28733458

TgeneDGCR8

GO:0031053

primary miRNA processing

15531877|15574589|24449907|24910438


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-97-A4M3-01AWNT7Bchr22

46345800

-DGCR8chr22

20093700

+
TCGALDLUADTCGA-97-A4M3-01AWNT7Bchr22

46345804

-DGCR8chr22

20093700

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000339464ENST00000351989WNT7Bchr22

46345800

-DGCR8chr22

20093700

+
Frame-shiftENST00000339464ENST00000383024WNT7Bchr22

46345800

-DGCR8chr22

20093700

+
Frame-shiftENST00000339464ENST00000407755WNT7Bchr22

46345800

-DGCR8chr22

20093700

+
Frame-shiftENST00000409496ENST00000351989WNT7Bchr22

46345800

-DGCR8chr22

20093700

+
Frame-shiftENST00000409496ENST00000383024WNT7Bchr22

46345800

-DGCR8chr22

20093700

+
Frame-shiftENST00000409496ENST00000407755WNT7Bchr22

46345800

-DGCR8chr22

20093700

+
Frame-shiftENST00000410089ENST00000351989WNT7Bchr22

46345800

-DGCR8chr22

20093700

+
Frame-shiftENST00000410089ENST00000383024WNT7Bchr22

46345800

-DGCR8chr22

20093700

+
Frame-shiftENST00000410089ENST00000407755WNT7Bchr22

46345800

-DGCR8chr22

20093700

+
Frame-shiftENST00000410058ENST00000351989WNT7Bchr22

46345800

-DGCR8chr22

20093700

+
Frame-shiftENST00000410058ENST00000383024WNT7Bchr22

46345800

-DGCR8chr22

20093700

+
Frame-shiftENST00000410058ENST00000407755WNT7Bchr22

46345800

-DGCR8chr22

20093700

+
Frame-shiftENST00000339464ENST00000351989WNT7Bchr22

46345804

-DGCR8chr22

20093700

+
Frame-shiftENST00000339464ENST00000383024WNT7Bchr22

46345804

-DGCR8chr22

20093700

+
Frame-shiftENST00000339464ENST00000407755WNT7Bchr22

46345804

-DGCR8chr22

20093700

+
Frame-shiftENST00000409496ENST00000351989WNT7Bchr22

46345804

-DGCR8chr22

20093700

+
Frame-shiftENST00000409496ENST00000383024WNT7Bchr22

46345804

-DGCR8chr22

20093700

+
Frame-shiftENST00000409496ENST00000407755WNT7Bchr22

46345804

-DGCR8chr22

20093700

+
Frame-shiftENST00000410089ENST00000351989WNT7Bchr22

46345804

-DGCR8chr22

20093700

+
Frame-shiftENST00000410089ENST00000383024WNT7Bchr22

46345804

-DGCR8chr22

20093700

+
Frame-shiftENST00000410089ENST00000407755WNT7Bchr22

46345804

-DGCR8chr22

20093700

+
Frame-shiftENST00000410058ENST00000351989WNT7Bchr22

46345804

-DGCR8chr22

20093700

+
Frame-shiftENST00000410058ENST00000383024WNT7Bchr22

46345804

-DGCR8chr22

20093700

+
Frame-shiftENST00000410058ENST00000407755WNT7Bchr22

46345804

-DGCR8chr22

20093700

+

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FusionProtFeatures for WNT7B_DGCR8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WNT7B

P56706

DGCR8

Q8WYQ5

Ligand for members of the frizzled family of seventransmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells.Required for normal fusion of the chorion and the allantois duringplacenta development. {ECO:0000250|UniProtKB:P28047}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WNT7B_DGCR8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WNT7B_DGCR8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WNT7BCASK, TCEB1, CUL3, WNT4, WNT7A, TRIM25DGCR8NCL, HSPA5, HSPA8, HNRNPR, DDX5, DDX17, FUS, HNRNPH1, DHX9, HNRNPU, ILF3, DROSHA, CUL3, APP, PRPF4, MAPRE2, NAT10, PLEK2, RPRD2, FLII, CDT1, SRPK1, SRPK2, CDKN2A, ERH, MAPK1, PRMT1, PYCRL, RAE1, MEOX2, BMI1, EWSR1, HNRNPUL1, KIF11, SYN1, CTR9, TFG, ZWINT, KLF8, FANCI, FAM46A, SMC6, KIF15, TLN2, RRP8, ZNF7, PABPC4L, CENPI, ITGB3BP, CENPO, SHQ1, CENPC, CENPN, CENPU, ZNF189, PAPD5, ZNF70, CENPQ, ZNF483, ZNF800, NSA2, WHSC1, GNL2, UPF1, BEND7, NMNAT1, RPL26L1, DKC1, TTF1, DDX31, KNOP1, BRIX1, RALY, GTPBP4, MPHOSPH10, ZNF324B, DDX24, CCDC137, ZNF689, NOP2, GLYR1, ZFP62, DDX27, REXO4, DDX10, MECP2, UTP23, ZCCHC7, RPF2, ZBTB48, FTSJ3, LARP1, ZNF22, RPL17, MAK16, STAU2, LARP1B, RBM28, DNTTIP2, ZNF771, NVL, ZC3HAV1, MOV10, DDX18, KIAA0020, SURF6, FCF1, PINX1, SPTY2D1, ZNF646, PAK1IP1, RPLP2, CENPH, ZNF777, CTCF, DHX30, NOL10, RPS13, REPIN1, PRKRA, RPL7A, HIST2H2AB, RPL10A, WDR12, ZNF668, DDX56, NIFK, DDX54, POP1, RPS8, HERC5, NOC3L, NR2E1, KHSRP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WNT7B_DGCR8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WNT7B_DGCR8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDGCR8C0036341Schizophrenia3PSYGENET
TgeneDGCR8C0004936Mental disorders1CTD_human
TgeneDGCR8C0011570Mental Depression1PSYGENET
TgeneDGCR8C0011581Depressive disorder1PSYGENET
TgeneDGCR8C0033975Psychotic Disorders1PSYGENET
TgeneDGCR8C0349204Nonorganic psychosis1PSYGENET