FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 4206

FusionGeneSummary for BLCAP_RSU1

check button Fusion gene summary
Fusion gene informationFusion gene name: BLCAP_RSU1
Fusion gene ID: 4206
HgeneTgene
Gene symbol

BLCAP

RSU1

Gene ID

10904

6251

Gene nameBLCAP, apoptosis inducing factorRas suppressor protein 1
SynonymsBC10RSP-1
Cytomap

20q11.23

10p13

Type of geneprotein-codingprotein-coding
Descriptionbladder cancer-associated proteinbladder cancer associated proteinbladder cancer related protein (10kD)ras suppressor protein 1ras suppressor protein 1 variant 1ras suppressor protein 1 variant 2ras suppressor protein 1 variant 3ras suppressor protein 1 variant 5rsu-1
Modification date2018051920180522
UniProtAcc

P62952

Q15404

Ensembl transtripts involved in fusion geneENST00000411780, ENST00000397137, 
ENST00000373537, ENST00000414542, 
ENST00000397135, ENST00000397134, 
ENST00000397131, 
ENST00000377921, 
ENST00000345264, ENST00000602389, 
ENST00000464074, 
Fusion gene scores* DoF score6 X 6 X 1=364 X 4 X 2=32
# samples 64
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BLCAP [Title/Abstract] AND RSU1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBLCAP

GO:0030262

apoptotic nuclear changes

17031575


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF734311BLCAPchr20

36151536

+RSU1chr10

16635440

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000411780ENST00000377921BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000411780ENST00000345264BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000411780ENST00000602389BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-5UTRENST00000411780ENST00000464074BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000397137ENST00000377921BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000397137ENST00000345264BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000397137ENST00000602389BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-5UTRENST00000397137ENST00000464074BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000373537ENST00000377921BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000373537ENST00000345264BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000373537ENST00000602389BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-5UTRENST00000373537ENST00000464074BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000414542ENST00000377921BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000414542ENST00000345264BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000414542ENST00000602389BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-5UTRENST00000414542ENST00000464074BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000397135ENST00000377921BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000397135ENST00000345264BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000397135ENST00000602389BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-5UTRENST00000397135ENST00000464074BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000397134ENST00000377921BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000397134ENST00000345264BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000397134ENST00000602389BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-5UTRENST00000397134ENST00000464074BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000397131ENST00000377921BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000397131ENST00000345264BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-3CDSENST00000397131ENST00000602389BLCAPchr20

36151536

+RSU1chr10

16635440

-
intron-5UTRENST00000397131ENST00000464074BLCAPchr20

36151536

+RSU1chr10

16635440

-

Top

FusionProtFeatures for BLCAP_RSU1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BLCAP

P62952

RSU1

Q15404

May regulate cell proliferation and coordinate apoptosisand cell cycle progression via a novel mechanism independent ofboth p53/TP53 and NF-kappa-B. {ECO:0000269|PubMed:17031575}. Potentially plays a role in the Ras signal transductionpathway. Capable of suppressing v-Ras transformation in vitro.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BLCAP_RSU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BLCAP_RSU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BLCAP_RSU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for BLCAP_RSU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRSU1C0029456Osteoporosis1CTD_human
TgeneRSU1C0263454Chloracne1CTD_human