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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42054

FusionGeneSummary for WNK4_MT1G

check button Fusion gene summary
Fusion gene informationFusion gene name: WNK4_MT1G
Fusion gene ID: 42054
HgeneTgene
Gene symbol

WNK4

MT1G

Gene ID

65266

4495

Gene nameWNK lysine deficient protein kinase 4metallothionein 1G
SynonymsPHA2B|PRKWNK4MT1|MT1K
Cytomap

17q21.2

16q13

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase WNK4protein kinase lysine-deficient 4protein kinase with no lysine 4metallothionein-1GMT-1GMT-1KMT-IGmetallothionein-1Kmetallothionein-IG
Modification date2018052320180523
UniProtAcc

Q96J92

P13640

Ensembl transtripts involved in fusion geneENST00000246914, ENST00000587705, 
ENST00000444837, ENST00000569500, 
ENST00000379811, ENST00000568675, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WNK4 [Title/Abstract] AND MT1G [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMT1G

GO:0045926

negative regulation of growth

18332874

TgeneMT1G

GO:0071294

cellular response to zinc ion

7559655


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1H91370WNK4chr17

40939214

-MT1Gchr16

56701936

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000246914ENST00000444837WNK4chr17

40939214

-MT1Gchr16

56701936

-
intron-5UTRENST00000246914ENST00000569500WNK4chr17

40939214

-MT1Gchr16

56701936

-
intron-5UTRENST00000246914ENST00000379811WNK4chr17

40939214

-MT1Gchr16

56701936

-
intron-5UTRENST00000246914ENST00000568675WNK4chr17

40939214

-MT1Gchr16

56701936

-
intron-5UTRENST00000587705ENST00000444837WNK4chr17

40939214

-MT1Gchr16

56701936

-
intron-5UTRENST00000587705ENST00000569500WNK4chr17

40939214

-MT1Gchr16

56701936

-
intron-5UTRENST00000587705ENST00000379811WNK4chr17

40939214

-MT1Gchr16

56701936

-
intron-5UTRENST00000587705ENST00000568675WNK4chr17

40939214

-MT1Gchr16

56701936

-

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FusionProtFeatures for WNK4_MT1G


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WNK4

Q96J92

MT1G

P13640

Serine/threonine kinase which plays an important role inthe regulation of electrolyte homeostasis, cell signaling,survival and proliferation. Acts as an activator and inhibitor ofsodium-coupled chloride cotransporters and potassium-coupledchloride cotransporters respectively. Activates SCNN1A, SCNN1B,SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of thethiazide-sensitive Na-Cl cotransporter, SLC12A3, byphosphorylation which appears to prevent membrane trafficking ofSLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via akinase-independent mechanism by which it induces clearance of theprotein from the cell surface by clathrin-dependent endocytosis.WNK4 appears to act as a molecular switch that can vary thebalance between NaCl reabsorption and K(+) secretion to maintainintegrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffoldto inhibit SLC4A4 as well as CFTR activities and surfaceexpression, recruits STK39 which mediates the inhibition (Bysimilarity). {ECO:0000250|UniProtKB:Q80UE6,ECO:0000269|PubMed:20525693}. Metallothioneins have a high content of cysteineresidues that bind various heavy metals; these proteins aretranscriptionally regulated by both heavy metals andglucocorticoids.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WNK4_MT1G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WNK4_MT1G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WNK4_MT1G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WNK4_MT1G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWNK4C1840390Pseudohypoaldosteronism, Type IIb3ORPHANET;UNIPROT
HgeneWNK4C0020538Hypertensive disease1CTD_human
HgeneWNK4C0033805Pseudohypoaldosteronism1CTD_human
HgeneWNK4C0036341Schizophrenia1PSYGENET
TgeneMT1GC0014859Esophageal Neoplasms1CTD_human