FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42037

FusionGeneSummary for WNK1_EIF3G

check button Fusion gene summary
Fusion gene informationFusion gene name: WNK1_EIF3G
Fusion gene ID: 42037
HgeneTgene
Gene symbol

WNK1

EIF3G

Gene ID

65125

8666

Gene nameWNK lysine deficient protein kinase 1eukaryotic translation initiation factor 3 subunit G
SynonymsHSAN2|HSN2|KDP|PPP1R167|PRKWNK1|PSK|p65EIF3-P42|EIF3S4|eIF3-delta|eIF3-p44
Cytomap

12p13.33

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase WNK1WNK lysine deficient protein kinase 1 isoformerythrocyte 65 kDa proteinprostate-derived sterile 20-like kinaseprotein kinase with no lysine 1protein phosphatase 1, regulatory subunit 167serine/threonine-protein kieukaryotic translation initiation factor 3 subunit Geukaryotic translation initiation factor 3 RNA-binding subuniteukaryotic translation initiation factor 3 subunit p42eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa
Modification date2018052320180523
UniProtAcc

Q9H4A3

O75821

Ensembl transtripts involved in fusion geneENST00000535572, ENST00000537687, 
ENST00000315939, ENST00000447667, 
ENST00000530271, ENST00000540360, 
ENST00000340908, ENST00000574564, 
ENST00000253108, ENST00000587168, 
Fusion gene scores* DoF score15 X 10 X 10=15002 X 2 X 2=8
# samples 192
** MAII scorelog2(19/1500*10)=-2.9808911770523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: WNK1 [Title/Abstract] AND EIF3G [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWNK1

GO:0006468

protein phosphorylation

10660600

HgeneWNK1

GO:0010923

negative regulation of phosphatase activity

19389623

HgeneWNK1

GO:0023016

signal transduction by trans-phosphorylation

16669787

HgeneWNK1

GO:0035556

intracellular signal transduction

10660600

TgeneEIF3G

GO:0006413

translational initiation

17581632

TgeneEIF3G

GO:0075525

viral translational termination-reinitiation

21347434


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-09-2044-01BWNK1chr12

939326

+EIF3Gchr19

10230376

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000535572ENST00000253108WNK1chr12

939326

+EIF3Gchr19

10230376

-
5CDS-5UTRENST00000535572ENST00000587168WNK1chr12

939326

+EIF3Gchr19

10230376

-
Frame-shiftENST00000537687ENST00000253108WNK1chr12

939326

+EIF3Gchr19

10230376

-
5CDS-5UTRENST00000537687ENST00000587168WNK1chr12

939326

+EIF3Gchr19

10230376

-
Frame-shiftENST00000315939ENST00000253108WNK1chr12

939326

+EIF3Gchr19

10230376

-
5CDS-5UTRENST00000315939ENST00000587168WNK1chr12

939326

+EIF3Gchr19

10230376

-
intron-3CDSENST00000447667ENST00000253108WNK1chr12

939326

+EIF3Gchr19

10230376

-
intron-5UTRENST00000447667ENST00000587168WNK1chr12

939326

+EIF3Gchr19

10230376

-
Frame-shiftENST00000530271ENST00000253108WNK1chr12

939326

+EIF3Gchr19

10230376

-
5CDS-5UTRENST00000530271ENST00000587168WNK1chr12

939326

+EIF3Gchr19

10230376

-
3UTR-3CDSENST00000540360ENST00000253108WNK1chr12

939326

+EIF3Gchr19

10230376

-
3UTR-5UTRENST00000540360ENST00000587168WNK1chr12

939326

+EIF3Gchr19

10230376

-
intron-3CDSENST00000340908ENST00000253108WNK1chr12

939326

+EIF3Gchr19

10230376

-
intron-5UTRENST00000340908ENST00000587168WNK1chr12

939326

+EIF3Gchr19

10230376

-
intron-3CDSENST00000574564ENST00000253108WNK1chr12

939326

+EIF3Gchr19

10230376

-
intron-5UTRENST00000574564ENST00000587168WNK1chr12

939326

+EIF3Gchr19

10230376

-

Top

FusionProtFeatures for WNK1_EIF3G


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WNK1

Q9H4A3

EIF3G

O75821

RNA-binding component of the eukaryotic translationinitiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis (PubMed:17581632,PubMed:25849773, PubMed:27462815). The eIF-3 complex associateswith the 40S ribosome and facilitates the recruitment of eIF-1,eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNArecruitment to the 43S PIC and scanning of the mRNA for AUGrecognition. The eIF-3 complex is also required for disassemblyand recycling of post-termination ribosomal complexes andsubsequently prevents premature joining of the 40S and 60Sribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of asubset of mRNAs involved in cell proliferation, including cellcycling, differentiation and apoptosis, and uses different modesof RNA stem-loop binding to exert either translational activationor repression (PubMed:25849773). This subunit can bind 18S rRNA.{ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632,ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. (Microbial infection) In case of FCV infection, plays arole in the ribosomal termination-reinitiation event leading tothe translation of VP2 (PubMed:18056426).{ECO:0000269|PubMed:18056426}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for WNK1_EIF3G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for WNK1_EIF3G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WNK1E2F3, CLTC, FLNC, ATP8, PRKAR1A, PRKAR1B, SLC9A1, ZYX, CSDE1, TSC22D1, BAG3, RANBP9, COPS5, TNRC6A, ZNF106, YWHAE, YWHAZ, MAP2K1, YWHAG, WNK1, WNK2, GLIS2, MYC, SGK1, NEDD4L, ATXN1, KLHL3, VCP, YWHAQ, MMS19, KLHL2, PFKP, ARAF, PVR, UPF2, YWHAB, EIF2B2, EIF3K, HNRNPD, ADRB2, FAM96B, FHL3, UBE2I, METTL6, TSC22D4, AAMP, MED4, XPO1, CDC42, CLTB, GAK, PICALM, GTSE1, SPATA1, AARSD1, HAO2, HSPA8, BAG4, SERPINB13, RAPGEF5, STAMBPL1, MLF1, PLEC, AAK1, TRIM25EIF3GMPP6, EIF3C, EIF1B, EIF3A, EIF3K, EIF5, EPB41, EIF3B, EIF3D, EIF3G, EIF3H, EIF3F, USP3, GADD45G, SNCA, TK1, SMN1, PIN1, PKN2, ACD, POT1, CUL3, EIF3E, APP, EIF3I, EIF3L, EIF3M, DDX3X, PAN2, CD81, IGSF8, ICAM1, NPM1, DYNC1I2, NCL, GOLGA2, FAM9B, PAIP1, EIF1, EIF3CL, MSI2, MTHFD1, SFN, NTRK1, KRAS, HERC2, PRKAG1, AHSA1, RPL10, CERKL, CYLD, DLD, G3BP1, LMNA, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for WNK1_EIF3G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for WNK1_EIF3G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWNK1C0020538Hypertensive disease1CTD_human
HgeneWNK1C0022658Kidney Diseases1CTD_human
HgeneWNK1C0033805Pseudohypoaldosteronism1CTD_human