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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4201

FusionGeneSummary for BIVM-ERCC5_RBM26

check button Fusion gene summary
Fusion gene informationFusion gene name: BIVM-ERCC5_RBM26
Fusion gene ID: 4201
HgeneTgene
Gene symbol

BIVM-ERCC5

RBM26

Gene ID

100533467

64062

Gene nameBIVM-ERCC5 readthroughRNA binding motif protein 26
SynonymsERCC5-202ARRS2|C13orf10|PPP1R132|PRO1777|SE70-2|ZC3H17
Cytomap

13q33.1

13q31.1

Type of geneprotein-codingprotein-coding
DescriptionBIVM-ERCC5 proteinRNA-binding protein 26CTCL tumor antigen se70-2acidic rich RS domain containing 2cutaneous T-cell lymphoma tumor antigen se70-2protein phosphatase 1, regulatory 132
Modification date2018040920180523
UniProtAcc

Q5T8P6

Ensembl transtripts involved in fusion geneENST00000602836, ENST00000267229, 
ENST00000438737, ENST00000438724, 
ENST00000461008, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 1=16
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BIVM-ERCC5 [Title/Abstract] AND RBM26 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRBM26

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1N86990BIVM-ERCC5chr13

103518629

+RBM26chr13

79940278

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000602836ENST00000267229BIVM-ERCC5chr13

103518629

+RBM26chr13

79940278

-
In-frameENST00000602836ENST00000438737BIVM-ERCC5chr13

103518629

+RBM26chr13

79940278

-
In-frameENST00000602836ENST00000438724BIVM-ERCC5chr13

103518629

+RBM26chr13

79940278

-
5CDS-5UTRENST00000602836ENST00000461008BIVM-ERCC5chr13

103518629

+RBM26chr13

79940278

-

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FusionProtFeatures for BIVM-ERCC5_RBM26


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BIVM-ERCC5

RBM26

Q5T8P6

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BIVM-ERCC5_RBM26


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_BIVM-ERCC5_ENST00000602836_chr13_103518629_+_RBM26_ENST00000267229_chr13_79940278_-_0aa

>In-frame_BIVM-ERCC5_ENST00000602836_chr13_103518629_+_RBM26_ENST00000438737_chr13_79940278_-_0aa

>In-frame_BIVM-ERCC5_ENST00000602836_chr13_103518629_+_RBM26_ENST00000438724_chr13_79940278_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_BIVM-ERCC5_ENST00000602836_chr13_103518629_+_RBM26_ENST00000267229_chr13_79940278_-_0nt

>In-frame_BIVM-ERCC5_ENST00000602836_chr13_103518629_+_RBM26_ENST00000438737_chr13_79940278_-_0nt

>In-frame_BIVM-ERCC5_ENST00000602836_chr13_103518629_+_RBM26_ENST00000438724_chr13_79940278_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_BIVM-ERCC5_ENST00000602836_chr13_103518629_+_RBM26_ENST00000267229_chr13_79940278_-_0nt

>In-frame_BIVM-ERCC5_ENST00000602836_chr13_103518629_+_RBM26_ENST00000438737_chr13_79940278_-_0nt

>In-frame_BIVM-ERCC5_ENST00000602836_chr13_103518629_+_RBM26_ENST00000438724_chr13_79940278_-_0nt


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FusionGenePPI for BIVM-ERCC5_RBM26


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BIVM-ERCC5_RBM26


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BIVM-ERCC5_RBM26


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource