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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42000

FusionGeneSummary for WIPF2_CDK12

check button Fusion gene summary
Fusion gene informationFusion gene name: WIPF2_CDK12
Fusion gene ID: 42000
HgeneTgene
Gene symbol

WIPF2

CDK12

Gene ID

147179

51755

Gene nameWAS/WASL interacting protein family member 2cyclin dependent kinase 12
SynonymsWICH|WIRECRK7|CRKR|CRKRS
Cytomap

17q21.2

17q12

Type of geneprotein-codingprotein-coding
DescriptionWAS/WASL-interacting protein family member 2WASP-binding proteinWASP-interacting protein-related proteinWIP- and CR16-homologous proteinWIP-related proteincyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12
Modification date2018052320180523
UniProtAcc

Q8TF74

Q9NYV4

Ensembl transtripts involved in fusion geneENST00000494757, ENST00000323571, 
ENST00000585043, ENST00000394103, 
ENST00000536600, ENST00000583130, 
ENST00000430627, ENST00000447079, 
ENST00000559545, 
Fusion gene scores* DoF score28 X 7 X 15=294027 X 15 X 12=4860
# samples 2831
** MAII scorelog2(28/2940*10)=-3.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(31/4860*10)=-3.97061619321891
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WIPF2 [Title/Abstract] AND CDK12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDK12

GO:0046777

protein autophosphorylation

11683387


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A04W-01AWIPF2chr17

38421398

+CDK12chr17

37700502

+
TCGALDOVTCGA-3P-A9WA-01AWIPF2chr17

38421398

+CDK12chr17

37721013

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000494757ENST00000430627WIPF2chr17

38421398

+CDK12chr17

37700502

+
3UTR-intronENST00000494757ENST00000447079WIPF2chr17

38421398

+CDK12chr17

37700502

+
3UTR-intronENST00000494757ENST00000559545WIPF2chr17

38421398

+CDK12chr17

37700502

+
5CDS-intronENST00000323571ENST00000430627WIPF2chr17

38421398

+CDK12chr17

37700502

+
5CDS-intronENST00000323571ENST00000447079WIPF2chr17

38421398

+CDK12chr17

37700502

+
5CDS-intronENST00000323571ENST00000559545WIPF2chr17

38421398

+CDK12chr17

37700502

+
5CDS-intronENST00000585043ENST00000430627WIPF2chr17

38421398

+CDK12chr17

37700502

+
5CDS-intronENST00000585043ENST00000447079WIPF2chr17

38421398

+CDK12chr17

37700502

+
5CDS-intronENST00000585043ENST00000559545WIPF2chr17

38421398

+CDK12chr17

37700502

+
intron-intronENST00000394103ENST00000430627WIPF2chr17

38421398

+CDK12chr17

37700502

+
intron-intronENST00000394103ENST00000447079WIPF2chr17

38421398

+CDK12chr17

37700502

+
intron-intronENST00000394103ENST00000559545WIPF2chr17

38421398

+CDK12chr17

37700502

+
intron-intronENST00000536600ENST00000430627WIPF2chr17

38421398

+CDK12chr17

37700502

+
intron-intronENST00000536600ENST00000447079WIPF2chr17

38421398

+CDK12chr17

37700502

+
intron-intronENST00000536600ENST00000559545WIPF2chr17

38421398

+CDK12chr17

37700502

+
5CDS-intronENST00000583130ENST00000430627WIPF2chr17

38421398

+CDK12chr17

37700502

+
5CDS-intronENST00000583130ENST00000447079WIPF2chr17

38421398

+CDK12chr17

37700502

+
5CDS-intronENST00000583130ENST00000559545WIPF2chr17

38421398

+CDK12chr17

37700502

+
3UTR-intronENST00000494757ENST00000430627WIPF2chr17

38421398

+CDK12chr17

37721013

+
3UTR-intronENST00000494757ENST00000447079WIPF2chr17

38421398

+CDK12chr17

37721013

+
3UTR-3UTRENST00000494757ENST00000559545WIPF2chr17

38421398

+CDK12chr17

37721013

+
5CDS-intronENST00000323571ENST00000430627WIPF2chr17

38421398

+CDK12chr17

37721013

+
5CDS-intronENST00000323571ENST00000447079WIPF2chr17

38421398

+CDK12chr17

37721013

+
5CDS-3UTRENST00000323571ENST00000559545WIPF2chr17

38421398

+CDK12chr17

37721013

+
5CDS-intronENST00000585043ENST00000430627WIPF2chr17

38421398

+CDK12chr17

37721013

+
5CDS-intronENST00000585043ENST00000447079WIPF2chr17

38421398

+CDK12chr17

37721013

+
5CDS-3UTRENST00000585043ENST00000559545WIPF2chr17

38421398

+CDK12chr17

37721013

+
intron-intronENST00000394103ENST00000430627WIPF2chr17

38421398

+CDK12chr17

37721013

+
intron-intronENST00000394103ENST00000447079WIPF2chr17

38421398

+CDK12chr17

37721013

+
intron-3UTRENST00000394103ENST00000559545WIPF2chr17

38421398

+CDK12chr17

37721013

+
intron-intronENST00000536600ENST00000430627WIPF2chr17

38421398

+CDK12chr17

37721013

+
intron-intronENST00000536600ENST00000447079WIPF2chr17

38421398

+CDK12chr17

37721013

+
intron-3UTRENST00000536600ENST00000559545WIPF2chr17

38421398

+CDK12chr17

37721013

+
5CDS-intronENST00000583130ENST00000430627WIPF2chr17

38421398

+CDK12chr17

37721013

+
5CDS-intronENST00000583130ENST00000447079WIPF2chr17

38421398

+CDK12chr17

37721013

+
5CDS-3UTRENST00000583130ENST00000559545WIPF2chr17

38421398

+CDK12chr17

37721013

+

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FusionProtFeatures for WIPF2_CDK12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WIPF2

Q8TF74

CDK12

Q9NYV4

Plays an active role in the formation of cell surfaceprotrusions downstream of activated PDGFB receptors. Plays animportant role in actin-microspike formation through cooperationwith WASL. May cooperate with WASP and WASL to induce mobilizationand reorganization of the actin filament system.{ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II(POLR2A), thereby acting as a key regulator of transcriptionelongation. Regulates the expression of genes involved in DNArepair and is required for the maintenance of genomic stability.Preferentially phosphorylates 'Ser-5' in CTD repeats that arealready phosphorylated at 'Ser-7', but can also phosphorylate'Ser-2'. Required for RNA splicing, possibly by phosphorylatingSRSF1/SF2. Involved in regulation of MAP kinase activity, possiblyleading to affect the response to estrogen inhibitors.{ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820,ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619,ECO:0000269|PubMed:24662513}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WIPF2_CDK12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WIPF2_CDK12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WIPF2DNMBP, WAS, NCK2, GRB2, ITSN2, SH3KBP1, WASL, EIF4A3, TXLNG, SLC4A1AP, HNRNPDL, ZFAND5, ZNF830, TCERG1, APBB1, WWOX, PACSIN2, NCK1, CDH1, TRIM25CDK12MGMT, SRRM2, RBM39, ELAVL1, MYC, PRPF4, CDK13, CCNK, TRIM24, IPPK, VPS51, ZNF606, TCEB3, BARD1, PAXIP1, PRPF40A, EWSR1, CDK20, CDK9, PIN1, RPL14, ACAA1, MAP4K4, SCAF4, SUPT16H, SRPK2, CLK1, BCLAF1, RNPS1, SNW1, PCGF1, CDX1, RPL37A, RRS1, ZNF2, FGF8, RPS14, WEE1, LASP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WIPF2_CDK12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WIPF2_CDK12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource