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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41976

FusionGeneSummary for WHSC1L1_PSD3

check button Fusion gene summary
Fusion gene informationFusion gene name: WHSC1L1_PSD3
Fusion gene ID: 41976
HgeneTgene
Gene symbol

WHSC1L1

PSD3

Gene ID

54904

23362

Gene namenuclear receptor binding SET domain protein 3pleckstrin and Sec7 domain containing 3
SynonymsKMT3F|KMT3G|WHISTLE|WHSC1L1|pp14328EFA6D|EFA6R|HCA67
Cytomap

8p11.23

8p22

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase NSD3WHSC1-like 1 isoform 9 with methyltransferase activity to lysineWolf-Hirschhorn syndrome candidate 1-like 1nuclear SET domain-containing protein 3protein whistlePH and SEC7 domain-containing protein 3ADP-ribosylation factor guanine nucleotide factor 6epididymis tissue protein Li 20mPexchange factor for ADP-ribosylation factor guanine nucleotide factor 6exchange factor for ADP-ribosylation factor guanine nucle
Modification date2018051920180523
UniProtAcc

Q9NYI0

Ensembl transtripts involved in fusion geneENST00000317025, ENST00000433384, 
ENST00000527502, ENST00000316985, 
ENST00000525081, 		ENST00000327040, 
ENST00000440756, ENST00000286485, 
ENST00000428502, ENST00000523619, 
ENST00000520789, 
Fusion gene scores* DoF score19 X 10 X 10=19004 X 4 X 2=32
# samples 224
** MAII scorelog2(22/1900*10)=-3.11042398969365
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WHSC1L1 [Title/Abstract] AND PSD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWHSC1L1

GO:0016571

histone methylation

16682010


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A18U-01AWHSC1L1chr8

38146005

-PSD3chr8

18513195

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000317025ENST00000327040WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000317025ENST00000440756WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000317025ENST00000286485WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000317025ENST00000428502WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000317025ENST00000523619WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
5CDS-intronENST00000317025ENST00000520789WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000433384ENST00000327040WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000433384ENST00000440756WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000433384ENST00000286485WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000433384ENST00000428502WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000433384ENST00000523619WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
5CDS-intronENST00000433384ENST00000520789WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000527502ENST00000327040WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000527502ENST00000440756WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000527502ENST00000286485WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000527502ENST00000428502WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
Frame-shiftENST00000527502ENST00000523619WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
5CDS-intronENST00000527502ENST00000520789WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
intron-3CDSENST00000316985ENST00000327040WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
intron-3CDSENST00000316985ENST00000440756WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
intron-3CDSENST00000316985ENST00000286485WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
intron-3CDSENST00000316985ENST00000428502WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
intron-3CDSENST00000316985ENST00000523619WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
intron-intronENST00000316985ENST00000520789WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
intron-3CDSENST00000525081ENST00000327040WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
intron-3CDSENST00000525081ENST00000440756WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
intron-3CDSENST00000525081ENST00000286485WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
intron-3CDSENST00000525081ENST00000428502WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
intron-3CDSENST00000525081ENST00000523619WHSC1L1chr8

38146005

-PSD3chr8

18513195

-
intron-intronENST00000525081ENST00000520789WHSC1L1chr8

38146005

-PSD3chr8

18513195

-

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FusionProtFeatures for WHSC1L1_PSD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WHSC1L1

PSD3

Q9NYI0

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Guanine nucleotide exchange factor for ARF6.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WHSC1L1_PSD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WHSC1L1_PSD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WHSC1L1CBX3, KDM1B, CCNT1, BRD4, H2AFY, CRNN, BRD9, SMARCC1, BCL7C, SMARCA4, BCL7A, SS18L1, SMARCA2, DAXX, HOXC4, MNDA, SLU7, DOCK7, ETV3, GLYR1, H3F3C, HIST1H1A, SEPT6, SPAG8, STAC3, UBE2I, ZNF557, HIST3H3, MLLT6, CBX5, AKT1, ATM, BCAR3, CASP8, CDKN2A, CHEK2, ESR1, FGFR4, PAX2, PPM1D, RAD51, RB1CC1, TGFB1, HIST1H2BG, LSM3, YEATS4, BRD2, HIST1H3A, HIST1H4A, BPTF, BOD1L1, CHD8, CDC14BPSD3MLH1, PMS2, ARAP1, MX1, TP53, CTDSPL, PTPRA, PTPRG


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WHSC1L1_PSD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WHSC1L1_PSD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePSD3C0017638Glioma1CTD_human
TgenePSD3C0036341Schizophrenia1PSYGENET
TgenePSD3C0236733Amphetamine-Related Disorders1CTD_human