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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41963

FusionGeneSummary for WFDC3_OSBPL2

check button Fusion gene summary
Fusion gene informationFusion gene name: WFDC3_OSBPL2
Fusion gene ID: 41963
HgeneTgene
Gene symbol

WFDC3

OSBPL2

Gene ID

140686

9885

Gene nameWAP four-disulfide core domain 3oxysterol binding protein like 2
SynonymsWAP14|dJ447F3.3DFNA67|DNFA67|ORP-2|ORP2
Cytomap

20q13.12

20q13.33

Type of geneprotein-codingprotein-coding
DescriptionWAP four-disulfide core domain protein 3protease inhibitor WAP14putative protease inhibitor WAP14whey acidic protein 14oxysterol-binding protein-related protein 2OSBP-related protein 2
Modification date2018032920180523
UniProtAcc

Q8IUB2

Q9H1P3

Ensembl transtripts involved in fusion geneENST00000481847, ENST00000243938, 
ENST00000372632, ENST00000372630, 
ENST00000439951, ENST00000313733, 
ENST00000358053, ENST00000471817, 
Fusion gene scores* DoF score2 X 1 X 1=26 X 5 X 5=150
# samples 27
** MAII scorelog2(2/2*10)=3.32192809488736log2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WFDC3 [Title/Abstract] AND OSBPL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-MP-A4SV-01AWFDC3chr20

44387031

-OSBPL2chr20

60835037

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000481847ENST00000439951WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
5UTR-intronENST00000481847ENST00000313733WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
5UTR-intronENST00000481847ENST00000358053WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
5UTR-intronENST00000481847ENST00000471817WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
intron-intronENST00000243938ENST00000439951WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
intron-intronENST00000243938ENST00000313733WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
intron-intronENST00000243938ENST00000358053WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
intron-intronENST00000243938ENST00000471817WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
intron-intronENST00000372632ENST00000439951WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
intron-intronENST00000372632ENST00000313733WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
intron-intronENST00000372632ENST00000358053WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
intron-intronENST00000372632ENST00000471817WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
intron-intronENST00000372630ENST00000439951WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
intron-intronENST00000372630ENST00000313733WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
intron-intronENST00000372630ENST00000358053WFDC3chr20

44387031

-OSBPL2chr20

60835037

+
intron-intronENST00000372630ENST00000471817WFDC3chr20

44387031

-OSBPL2chr20

60835037

+

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FusionProtFeatures for WFDC3_OSBPL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WFDC3

Q8IUB2

OSBPL2

Q9H1P3

Binds phospholipids; exhibits strong binding tophosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). Binds 25-hydroxycholesterol(PubMed:17428193). {ECO:0000269|PubMed:11279184,ECO:0000269|PubMed:17428193}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WFDC3_OSBPL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WFDC3_OSBPL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WFDC3OSBPL2ELAVL1, VAPB, APBB2, HNRNPD, SGTB, BAG6, VAPA, ZFPL1, BIRC6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WFDC3_OSBPL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WFDC3_OSBPL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource