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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41960

FusionGeneSummary for WFDC2_PIGT

check button Fusion gene summary
Fusion gene informationFusion gene name: WFDC2_PIGT
Fusion gene ID: 41960
HgeneTgene
Gene symbol

WFDC2

PIGT

Gene ID

10406

51604

Gene nameWAP four-disulfide core domain 2phosphatidylinositol glycan anchor biosynthesis class T
SynonymsEDDM4|HE4|WAP5|dJ461P17.6CGI-06|MCAHS3|NDAP|PNH2
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
DescriptionWAP four-disulfide core domain protein 2WAP domain containing protein HE4-V4epididymal protein 4epididymal secretory protein E4epididymis-specific, whey-acidic protein type, four-disulfide coremajor epididymis-specific protein E4putative protease inGPI transamidase component PIG-TGPI transamidase subunitneurotrophin-regulated neuronal development-associated proteinphosphatidylinositol-glycan biosynthesis class T protein
Modification date2018052720180523
UniProtAcc

Q14508

Q969N2

Ensembl transtripts involved in fusion geneENST00000372676, ENST00000217425, 
ENST00000339946, ENST00000488143, 
ENST00000342873, 
ENST00000279036, 
ENST00000279035, ENST00000372689, 
ENST00000545755, ENST00000535404, 
ENST00000341555, ENST00000543458, 
Fusion gene scores* DoF score4 X 4 X 4=644 X 4 X 2=32
# samples 54
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WFDC2 [Title/Abstract] AND PIGT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1430-01AWFDC2chr20

44099172

+PIGTchr20

44076275

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000372676ENST00000279036WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000372676ENST00000279035WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000372676ENST00000372689WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000372676ENST00000545755WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000372676ENST00000535404WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000372676ENST00000341555WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000372676ENST00000543458WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000217425ENST00000279036WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000217425ENST00000279035WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000217425ENST00000372689WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000217425ENST00000545755WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000217425ENST00000535404WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000217425ENST00000341555WFDC2chr20

44099172

+PIGTchr20

44076275

+
5CDS-intronENST00000217425ENST00000543458WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000339946ENST00000279036WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000339946ENST00000279035WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000339946ENST00000372689WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000339946ENST00000545755WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000339946ENST00000535404WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000339946ENST00000341555WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000339946ENST00000543458WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000488143ENST00000279036WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000488143ENST00000279035WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000488143ENST00000372689WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000488143ENST00000545755WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000488143ENST00000535404WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000488143ENST00000341555WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000488143ENST00000543458WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000342873ENST00000279036WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000342873ENST00000279035WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000342873ENST00000372689WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000342873ENST00000545755WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000342873ENST00000535404WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000342873ENST00000341555WFDC2chr20

44099172

+PIGTchr20

44076275

+
intron-intronENST00000342873ENST00000543458WFDC2chr20

44099172

+PIGTchr20

44076275

+

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FusionProtFeatures for WFDC2_PIGT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WFDC2

Q14508

PIGT

Q969N2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WFDC2_PIGT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WFDC2_PIGT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WFDC2PTN, WDR81, PDIA5, WDR91, CRTAC1, PTPRF, EMC4, EIF1AX, GRN, FKBP7, BTBD1, LMNAPIGTPIGK, GPAA1, PIGS, PIGU, PRSS50, NTRK1, ERLEC1, TCTN3, TOR1AIP1, EYA2, USP54, TNIP1, CEP85L, HOXC9, RMND5B, FAM136A, ZMYND19, ARMC8, HELZ, MKLN1, RMND5A, GID8, MAEA, RANBP10, GID4, ZNF609, EGFL7, RANBP9, N4BP2L2, WDR26, POGLUT1, ANKRD40, BORA, STOM, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WFDC2_PIGT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WFDC2_PIGT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWFDC2C0023893Liver Cirrhosis, Experimental1CTD_human
TgenePIGTC0019050Hemoglobinuria, Paroxysmal1CTD_human
TgenePIGTC3809356MULTIPLE CONGENITAL ANOMALIES-HYPOTONIA-SEIZURES SYNDROME 31ORPHANET;UNIPROT