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Fusion gene ID: 41957 |
FusionGeneSummary for WEE1_MICU2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: WEE1_MICU2 | Fusion gene ID: 41957 | Hgene | Tgene | Gene symbol | WEE1 | MICU2 | Gene ID | 7465 | 221154 |
Gene name | WEE1 G2 checkpoint kinase | mitochondrial calcium uptake 2 | |
Synonyms | WEE1A|WEE1hu | 1110008L20Rik|EFHA1 | |
Cytomap | 11p15.4 | 13q12.11 | |
Type of gene | protein-coding | protein-coding | |
Description | wee1-like protein kinaseWEE1 homologWEE1+ homologwee1A kinase | calcium uptake protein 2, mitochondrialEF hand domain family A1EF hand domain family, member A1EF-hand domain-containing family member A1Smhs2 homolog | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P30291 | Q8IYU8 | |
Ensembl transtripts involved in fusion gene | ENST00000450114, ENST00000299613, | ENST00000382374, ENST00000479790, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 4=64 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: WEE1 [Title/Abstract] AND MICU2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MICU2 | GO:0006851 | mitochondrial calcium ion transmembrane transport | 24560927 |
Tgene | MICU2 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration | 24560927 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE002633 | WEE1 | chr11 | 9598115 | - | MICU2 | chr13 | 22069398 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000450114 | ENST00000382374 | WEE1 | chr11 | 9598115 | - | MICU2 | chr13 | 22069398 | + |
5CDS-5UTR | ENST00000450114 | ENST00000479790 | WEE1 | chr11 | 9598115 | - | MICU2 | chr13 | 22069398 | + |
Frame-shift | ENST00000299613 | ENST00000382374 | WEE1 | chr11 | 9598115 | - | MICU2 | chr13 | 22069398 | + |
5CDS-5UTR | ENST00000299613 | ENST00000479790 | WEE1 | chr11 | 9598115 | - | MICU2 | chr13 | 22069398 | + |
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FusionProtFeatures for WEE1_MICU2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
WEE1 | MICU2 |
Acts as a negative regulator of entry into mitosis (G2to M transition) by protecting the nucleus from cytoplasmicallyactivated cyclin B1-complexed CDK1 before the onset of mitosis bymediating phosphorylation of CDK1 on 'Tyr-15'. Specificallyphosphorylates and inactivates cyclin B1-complexed CDK1 reaching amaximum during G2 phase and a minimum as cells enter M phase.Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15'and phosphorylation of monomeric CDK1 does not occur. Its activityincreases during S and G2 phases and decreases at M phase when itis hyperphosphorylated. A correlated decrease in protein leveloccurs at M/G1 phase, probably due to its degradation. | Key regulator of mitochondrial calcium uniporter (MCU)required to limit calcium uptake by MCU when cytoplasmic calciumis low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1and MICU2 form a disulfide-linked heterodimer that stimulate andinhibit MCU activity, depending on the concentration of calcium(PubMed:24560927). MICU2 acts as a gatekeeper of MCU that sensescalcium level via its EF-hand domains: prevents channel opening atresting calcium, avoiding energy dissipation and cell-deathtriggering (PubMed:24560927). {ECO:0000269|PubMed:24503055,ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26387864,ECO:0000269|PubMed:26903221}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WEE1_MICU2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WEE1_MICU2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WEE1_MICU2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WEE1_MICU2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | WEE1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |